[1] SCHULTZ H P.Topological organic chemistry.Polyhedranes and prismanes[J].The Journal of Organic Chemistry,1965,30(5):1361-1364.

[2] ZHOU Z G.Liposome formulation of fullerene-based molecular diagnostic and therapeutic agents[J].Pharmaceutics,2013,5(4):525-541.

[3] CATALDO F,ROS T D.Medicinal chemistry and pharmacological potential of fullerenes and carbon nanotubes[M].Dordrecht:Springer,2008.
[4] MCEWEN C N,MCKAY R G,LARSEN B S.C
60 as a radical sponge[J].Journal of the American Chemical Society,1992,114(11):4412-4414.

[5] TUMANSKII B,KALINA O.Radical reactions of fullerenes and their derivatives[M].Dordrecht:Springer,2001.
[6] CHIANG L Y,LU F J,LIN J T.Free radical scavenging activity of water-soluble fullerenols[J].Journal of the Chemical Society,Chemical Communications,1995(12):1283-1284.
[7] SHI Z Q,LI Y L,WANG S,et al.Synthesis and antioxidative properties of polyphenol-fullerenes[J].Chinese Science Bulletin,2001,46(21):1790-1792.

[8] THILGEN C,DIEDERICH F.The higher fullerenes:covalent chemistry and chirality[C]//HIRSCH A.Fullerenes and related structures.Heidelberg:Springer,1999:135-171.
[9] LAMPARTH I,HIRSCH A.Water-soluble malonic acid derivatives of C
60 with a defined three-dimensional structure[J].Journal of the Chemical Society,Chemical Communications,1994(14):1727-1728.
[10] BAKRY R,VALLANT R M,NAJAM-UL-HAQ M,et al.Medicinal applications of fullerenes[J].International Journal of Nanomedicine,2007,2(4):639-649.
[11] TJOA M L,VAN VUGT J M G,GO A T J J,et al.Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction[J].Journal of Reproductive Immunology,2003,59(1):29-37.

[12] KIRWAN J P,KRISHNAN R K,WEAVER J A,et al.Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia[J].American Journal of Physiology:Endocrinology and Metabolism,2001,281(6):E1137-E1143.
[13] CATALANO P M,KIRWAN J P,HAUGEL-DE MOUZON S,et al.Gestational diabetes and insulin resistance:role in short- and long-term implications for mother and fetus[J].The Journal of Nutrition,2003,133(5 Suppl 2):1674S-1683S.
[14] LALLōS J P,BOSI P,SMIDT H,et al.Nutritional management of gut health in pigs around weaning[J].The Proceedings of the Nutrition Society,2007,66(2):260-268.

[15] LALLōS J P,BOUDRY G,FAVIER C,et al.Gut function and dysfunction in young pigs:physiology[J].Animal Research,2004,53(4):301-316.

[16] BROOKS P H,MORAN C A,BEAL J D,et al.Liquid feeding for the young piglet[C]//VARLEY M A,WISEMAN J.The weaner pig:nutrition and management.New York:CABI Publishing,2001:153-178.
[17] 宁章勇,刘思当,赵德明,等.热应激对肉仔鸡呼吸、消化和内分泌器官的形态和超微结构的影响[J].畜牧兽医学报,2003,34(6):558-561. NING Z Y,LIU S D,ZHAO D M,et al.The influence of heat stress on morphological and ultrastructure change of respiratory,digestive and endocrine tissues in broilers[J].Acta Veterinaria et Zootechnica Sinica,2003,34(6):558-561.(in Chinese)
[18] CAULFIELD M P,CAMBRIDGE H,FOSTER S F,et al.Heat stress:a major contributor to poor animal welfare associated with long-haul live export voyages[J].Veterinary Journal,2014,199(2):223-228.

[19] QUINTEIRO-FILHO W M,RODRIGUES M V,RIBEIRO A,et al.Acute heat stress impairs performance parameters and induces mild intestinal enteritis in broiler chickens:role of acute hypothalamic-pituitary-adrenal axis activation[J].Journal of Animal Science,2012,90(6):1986-1994.

[20] HALLIWELL B,WHITEMAN M.Measuring reactive species and oxidative damage
in vivo and in cell culture:how should you do it and what do the results mean?[J].British Journal of Pharmacology,2004,142(2):231-255.

[21] 陈小慧,张玲玲,谭胜男,等.奶牛氧化应激及抗氧化措施研究进展[J].黑龙江畜牧兽医,2018(21):53-56. CHEN X H,ZHANG L L,TAN S N,et al.Research progress of oxidative stress and antioxidant measures in dairy cows[J].Heilongjiang Animal Science and Veterinary Medicine,2018(21):53-56.(in Chinese)
[22] BERCHIERI-RONCHI C B,KIM S W,ZHAO Y,et al.Oxidative stress status of highly prolific sows during gestation and lactation[J].Animal,2011,5(11):1774-1779.

[23] SHWARTZ G,RHOADS M L,VANBAALE M J,et al.Effects of a supplemental yeast culture on heat-stressed lactating Holstein cows[J].Journal of Dairy Science,2009,92(3):935-942.

[24] GOURDINE J L,BIDANEL J P,NOBLET J,et al.Effects of breed and season on performance of lactating sows in a tropical humid climate[J].Journal of Animal Science,2006,84(2):360-369.

[25] FARMER C,KNIGHT C,FLINT D.Mammary gland involution and endocrine status in sows:effects of weaning age and lactation heat stress[J].Canadian Journal of Animal Science,2007,87(1):35-43.

[26] 郑秦文,林欣,陈思恋,等.热应激对体外培养小鼠乳腺上皮细胞cAMP、SOD和MDA水平的影响[J].黑龙江畜牧兽医,2016(3):15-18,21,260. ZHENG Q W,LIN X,CHEN S L,et al.Effect of heat stress on the levels of cAMP,SOD,and MDA in mouse mammary epithelial cells cultured
in vitro[J].Heilongjiang Animal Husbandry and Veterinary Medicine,2016(3):15-18,21,260.(in Chinese)
[27] NATHAN C,CUNNINGHAM-BUSSEL A.Beyond oxidative stress:an immunologist's guide to reactive oxygen species[J].Nature Reviews Immunology,2013,13(5):349-361.

[28] CAMPBELL A M,KASHGARIAN M,SHLOMCHIK M J.NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus[J].Science Translational Medicine,2012,4(157):157ra141.
[29] CAIELLI S,ATHALE S,DOMIC B,et al.Oxidized mitochondrial nucleoids released by neutrophils drive type Ⅰ interferon production in human lupus[J].The Journal of Experimental Medicine,2016,213(5):697-713.

[30] 郁军超,薛连璧.机体ROS的产生及对生物大分子的毒性作用[J].山东医药,2012,52(8):94-96,102. YU J C,XUE L B.Production of ROS and its toxic effect on biomacromolecules[J].Shandong Medical Journal,2012,52(8):94-96,102.(in Chinese)
[31] LIM C S,PORTER D W,ORANDLE M S,et al.Resolution of pulmonary inflammation induced by carbon nanotubes and fullerenes in mice:role of macrophage polarization[J].Frontiers in Immunology,2020,11:1186.
[32] PRYLUTSKA S,GRYNYUK I,SKATERNA T,et al.Toxicity of C
60 fullerene-cisplatin nanocomplex against Lewis lung carcinoma cells[J].Archives of Toxicology,2019,93(5):1213-1226.

[33] LOTHARIUS J,DUGAN L L,O'MALLEY K L.Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons[J].The Journal of Neuroscience,1999,19(4):1284-1293.

[34] BANERJEE K,MUNSHI S,SEN O,et al.Dopamine cytotoxicity involves both oxidative and nonoxidative pathways in SH-SY5Y cells:potential role of alpha-synuclein overexpression and proteasomal inhibition in the etiopathogenesis of Parkinson's disease[J].Parkinson's Disease,2014,2014:878935.
[35] DUGAN L L,LOVETT E G,QUICK K L,et al.Fullerene-based antioxidants and neurodegenerative disorders[J].Parkinsonism & Related Disorders,2001,7(3):243-246.

[36] ALI S S,HARDT J I,QUICK K L,et al.A biologically effective fullerene (C
60) derivative with superoxide dismutase mimetic properties[J].Free Radical Biology & Medicine,2004,37(8):1191-1202.

[37] BOGDANOVIĆ V,STANKOV K,ICEVIĆ I,et al.Fullerenol C
60(OH)
24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line[J].Journal of Radiation Research,2008,49(3):321-327.

[38] DUGAN L L,GABRIELSEN J K,YU S P,et al.Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons[J].Neurobiology of Disease,1996,3(2):129-135.

[39] DAROCZI B,KARI G,MCALEER M F,et al.In vivo radioprotection by the fullerene nanoparticle DF-1 as assessed in a zebrafish model[J].Clinical Cancer Research,2006,12(23):7086-7091.

[40] TSAI M C,CHEN Y H,CHIANG L Y.Polyhydroxylated C
60,fullerenol,a novel free-radical trapper,prevented hydrogen peroxide- and cumene hydroperoxide-elicited changes in rat hippocampus in-vitro[J].The Journal of Pharmacy and Pharmacology,1997,49(4):438-445.
[41] CONG W S,WANG P,QU Y,et al.Evaluation of the influence of fullerenol on aging and stress resistance using
Caenorhabditis elegans[J].Biomaterials,2015,42:78-86.
[42] ALI S S,XIONG C J,LUCERO J,et al.Gender differences in free radical homeostasis during aging:shorter-lived female C57BL6 mice have increased oxidative stress[J].Aging Cell,2006,5(6):565-574.

[43] 董润,刘敏,黄骁舾,等.富勒烯C
60对博来霉素诱导的小鼠肺纤维化的影响[J].中华医学杂志,2017,97(22):1740-1744. DONG R,LIU M,HUANG X X,et al.Effect of water-soluble C
60 fullerenes on pulmonary fibrosis induced by bleomycin in mice[J].National Medical Journal of China,2017,97(22):1740-1744.(in Chinese)
[44] 陈琪萍,何佳恒,马宗平等.富勒烯衍生物对X射线所致小鼠肝线粒体损伤的保护作用[J].辐射防护,2015,35(4):214-220. CHEN Q P,HE J H,MA Z P,et al.Protective effect of fullerene derivatives against mitochondria damage in rat liver induced by X-ray[J].Radiation Protection,2015,35(4):214-220.(in Chinese)
[45] TRAJKOVIĆ S,DOBRIĆ S,JAĆEVIĆ V,et al.Tissue-protective effects of fullerenol C
60(OH)
24 and amifostine in irradiated rats[J].Colloids and Surfaces.B,Biointerfaces,2007,58(1):39-43.

[46] PEI Y L,CUI F A,DU X J,et al.Antioxidative nanofullerol inhibits macrophage activation and development of osteoarthritis in rats[J].International Journal of Nanomedicine,2019,14:4145-4155.
[47] ZHAO Q,LI Y,XU J,et al.Radioprotection by fullerenols of
Stylonychia mytilus exposed to gamma-rays[J].International Journal of Radiation Biology,2005,81(2):169-175.

[48] KUZNIETSOVA H M,DZIUBENKO N V,LYNCHAK O V,et al.Effects of pristine C
60 fullerenes on liver and pancreas in α-naphthylisothiocyanate-induced cholangitis[J].Digestive Diseases and Sciences,2020,65(1):215-224.

[49] LAO F,LI W,HAN D,et al.Fullerene derivatives protect endothelial cells against NO-induced damage[J].Nanotechnology,2009,20(22):225103.
[50] TORRES V M,SRDJENOVIC B,JACEVIC V,et al.Fullerenol C
60(OH)
24 prevents doxorubicin-induced acute cardiotoxicity in rats[J].Pharmacological Reports,2010,62(4):707-718.

[51] HUANG S S,TSAI S K,CHIH C L,et al.Neuroprotective effect of hexasulfobutylated C
60 on rats subjected to focal cerebral ischemia[J].Free Radical Biology & Medicine,2001,30(6):643-649.

[52] ELMASRY D M A,HEGAZI E S M,EL-SABAGH M,et al.Impact of N-acetyl cysteine (NAC) chit nanocomposite as antioxidant on broiler chicks[J].African Journal of Biological Sciences,2020,16(1):33-42.

[53] LI X H,WANG L R,LIU H,et al.C
60 fullerenes suppress reactive oxygen species toxicity damage in boar sperm[J].Nano-Micro Letters,2019,11(1):104.
[54] LIAO S M,LIU G,TAN B,et al.Fullerene C
60 protects against intestinal injury from deoxynivalenol toxicity by improving antioxidant capacity[J].Life,2021,11(6):491.
[55] TURRENS J F.Mitochondrial formation of reactive oxygen species[J].The Journal of Physiology,2003,552(Pt 2):335-344.
[56] LIU G F,FILIPOVIĆ M,IVANOVIĆ-BURMAZOVIĆ I,et al.High catalytic activity of dendritic C
60 monoadducts in metal-free superoxide dismutation[J].Angewandte Chemie-International Edition,2008,47(21):3991-3994.

[57] MOHAMMADI M R,NOJOOMI A,MOZAFARI M,et al.Nanomaterials engineering for drug delivery:a hybridization approach[J].Journal of Materials Chemistry B,2017,5(22):3995-4018.

[58] CHISTYAKOV V A,SMIRNOVA Y O,PRAZDNOVA E V,et al.Possible mechanisms of fullerene C
60 antioxidant action[J].BioMed Research International,2013,2013:821498.
[59] MISIRKIC M S,TODOROVIC-MARKOVIC B M,VUCICEVIC L M,et al.The protection of cells from nitric oxide-mediated apoptotic death by mechanochemically synthesized fullerene (C
60) nanoparticles[J].Biomaterials,2009,30(12):2319-2328.

[60] HU Z,HUANG Y D,GUAN W C,et al.The protective activities of water-soluble C
60 derivatives against nitric oxide-induced cytotoxicity in rat pheochromocytoma cells[J].Biomaterials,2010,31(34):8872-8881.

[61] LÜ J M,LIN P H,YAO Q Z,et al.Chemical and molecular mechanisms of antioxidants:experimental approaches and model systems[J].Journal of Cellular and Molecular Medicine,2010,14(4):840-860.

[62] OKUDA K,MASHINO T,HIROBE M.Superoxide radical quenching and cytochrome C peroxidase-like activity of C
60-dimalonic acid,C
62(COOH)
4[J].Bioorganic & Medicinal Chemistry Letters,1996,6(5):539-542.

[63] WANG I C,TAI L A,LEE D D,et al.C
60 and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation[J].Journal of Medicinal Chemistry,1999,42(22):4614-4620.

[64] OSUNA S,SWART M,SOLÀ M.On the mechanism of action of fullerene derivatives in superoxide dismutation[J].Chemistry-A European Journal,2010,16(10):3207-3214.

[65] SURH Y J,KUNDU J K,NA H K.Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals[J].Planta Medica,2008,74(13):1526-1539.

[66] CSISZÁR A,CSISZAR A,PINTO J T,et al.Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats[J].The Journals of Gerontology.Series A,Biological Sciences and Medical Sciences,2015,70(3):303-313.

[67] 熊小蔚.紫檀芪靶向Nrf2调控TLR-4/MyD88/NF-κB信号通路调控动脉粥样硬化大鼠细胞生物学信息分析[D].博士学位论文.南昌:南昌大学,2020. XIONG X W.Cellular biological information analysis of pterostilbene targeted regulation TLR-4/MyD88/NF-κB signaling pathway based on Nrf2 for atherosclerosis in rats[D].Ph.D.Thesis.Nanchang:Nanchang University,2020.(in Chinese)
[68] CHEN X,LIU J,CHEN S Y.Over-expression of Nrf2 diminishes ethanol-induced oxidative stress and apoptosis in neural crest cells by inducing an antioxidant response[J].Reproductive Toxicology,2013,42:102-109.
[69] KHAN N M,AHMAD I,HAQQI T M.Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis[J].Free Radical Biology and Medicine,2018,116:159-171.
[70] BOGNAR E,SARSZEGI Z,SZABO A,et al.Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin,a major red wine polyphenol[J].PLoS One,2013,8(6):e65355.
[71] MURAKAMI Y,KAWATA A,ITO S,et al.The radical scavenging activity and cytotoxicity of resveratrol,orcinol and 4-allylphenol and their inhibitory effects on
Cox-2 gene expression and NF-κB activation in RAW264.7 cells stimulated with
Porphyromonas gingivalis-fimbriae[J].In Vivo,2015,29(3):341-349.