REVIEW

Research Progress on Effects Mechanism of Butyric Acid on Subacute Ruminal Acidosis

  • DAI Peng ,
  • JIANG Yahui ,
  • WANG Zhisheng
Expand
  • 1. Key Laboratory of University in Cattle Low Carbon Breeding and Safety Production in Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China;
    2. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2021-07-12

  Online published: 2022-02-15

Abstract

Subacute ruminal acidosis (SARA) is a disease with high incidence in ruminant rearing due to nutrient metabolism disorder, which seriously affects the health and production of ruminants. In recent years, it has been found that butyric acid, as the main volatile fatty acid (VFA) in the rumen, plays a role in regulating cell proliferation and anti-inflammation. Based on recent studies, this paper focuses on butyric acid as a signal molecule and histone deacetylase inhibitors (HDACIs) to recognize G-protein coupled receptors (GPRs) from the mechanism of rumen barrier function and its induction of inflammatory response, it can promote histone acetylation, regulate downstream signaling pathways to improve rumen epithelial barrier function and alleviate the physiological process of inflammatory response, which provides a reference for further study on the effect of butyric acid on SARA in ruminants.

Cite this article

DAI Peng , JIANG Yahui , WANG Zhisheng . Research Progress on Effects Mechanism of Butyric Acid on Subacute Ruminal Acidosis[J]. Chinese Journal of Animal Nutrition, 2022 , 34(2) : 736 -744 . DOI: 10.3969/j.issn.1006-267x.2022.02.007

References

[1] GOZHO G N, PLAIZIER J C, KRAUSE D O, et al.Subacute ruminal acidosis induces ruminal lipopolysaccharide endotoxin release and triggers an inflammatory response[J].Journal of Dairy Science, 2005, 88(4):1399-1403.  
[2] GOZHO G N, KRAUSE D O, PLAIZIER J C.Ruminal lipopolysaccharide concentration and inflammatory response during grain-induced subacute ruminal acidosis in dairy cows[J].Journal of Dairy Science, 2007, 90(2):856-866.  
[3] KHAFIPOUR E, KRAUSE D O, PLAIZIER J C.Alfalfa pellet-induced subacute ruminal acidosis in dairy cows increases bacterial endotoxin in the rumen without causing inflammation[J].Journal of Dairy Science, 2009, 92(4):1712-1724.  
[4] BERGMAN E N.Energy contributions of volatile fatty acids from the gastrointestinal tract in various species[J].Physiological Reviews, 1990, 70(2):567-590.  
[5] GUILLOTEAU P, MARTIN L, EECKHAUT V, et al.From the gut to the peripheral tissues:the multiple effects of butyrate[J].Nutrition Research Reviews, 2010, 23(2):366-384.  
[6] 冉舒文, 慕春龙, 朱伟云.丁酸抑制溃疡性结肠炎分子机制的研究进展[J].世界华人消化杂志, 2018, 26(14):856-861. RAN S W, MU C L, ZHU W Y.Mechanisms for butyrate to inhibit ulcerative colitis[J].World Chinese Journal of Digestology, 2018, 26(14):856-861.(in Chinese)
[7] 姜茂成, 詹康, 贡笑笑, 等.不同pH和SCFAs对奶牛瘤胃上皮细胞SCFAs转运蛋白和GPR41表达的影响[J].中国农业大学学报, 2018, 23(10):63-70. JIANG M C, ZHAN K, GONG X X, et al.Effects of different pH and SCFAs on the expressions of SCFAs transport proteins and GPR41 in the rumen epithelial cells of dairy cow[J].Journal of China Agricultural University, 2018, 23(10):63-70.(in Chinese)
[8] 刘颖.丁酸梭状芽孢杆菌补料发酵的优化[D].硕士学位论文.武汉:湖北工业大学, 2018. LIU Y.Fed-batch culture optimazations for Clostridium butyricum[D].Master's Thesis.Wuhan:Hubei University of Technology, 2018.(in Chinese)
[9] PUCHALSKA P, CRAWFORD P A.Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics[J].Cell Metabolism, 2017, 25(2):262-284.  
[10] ZHANG R Y, LIU J H, JIANG L S, et al.Effect of high-concentrate diets on microbial composition, function, and the VFAs formation process in the rumen of dairy cows[J].Animal Feed Science and Technology, 2020, 269:114619.
[11] ASH R, BAIRD G D.Activation of volatile fatty acids in bovine liver and rumen epithelium.Evidence for control by autoregulation[J].Biochemical Journal, 1973, 136(2):311-319.  
[12] 汪水平, 王文娟, 谭支良.离体瘤胃上皮细胞在瘤胃代谢中的研究进展[J].家畜生态学报, 2006, 27(2):1-4. WANG S P, WANG W J, TAN Z L.Advance of isolated ruminal epithelial cells in the study of rumen metabolism[J].Journal of Domestic Animal Ecology, 2006, 27(2):1-4.(in Chinese)
[13] ASCHENBACH J R, ZEBELI Q, PATRA A K, et al.Symposium review:the importance of the ruminal epithelial barrier for a healthy and productive cow[J].Journal of Dairy Science, 2019, 102(2):1866-1882.  
[14] STEELE M A, CROOM J, KAHLER M, et al.Bovine rumen epithelium undergoes rapid structural adaptations during grain-induced subacute ruminal acidosis[J].American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 2011, 300(6):R1515-R1523.
[15] KLEVENHUSEN F, HOLLMANN M, PODSTATZKY-LICHTENSTEIN L, et al.Feeding barley grain-rich diets altered electrophysiological properties and permeability of the ruminal wall in a goat model[J].Journal of Dairy Science, 2013, 96(4):2293-2302.  
[16] 程萌.亚急性瘤胃酸中毒对奶山羊瘤胃上皮通透性及细胞连接蛋白表达的影响[D].硕士学位论文.呼和浩特:内蒙古农业大学, 2016. CHENG M.Effect of subacute ruminal acidosis on rumen epithelium permeability and intercellula junction protein expression in dairy goats[D].Master's Thesis.Hohhot:Inner Mongolia Agricultural University, 2016.(in Chinese)
[17] 刘军花.亚急性瘤胃酸中毒对山羊瘤胃上皮屏障功能的影响及其机制[D].博士学位论文.南京:南京农业大学, 2014. LIU J H.The effect of subacute ruminal acidosis on ruminal epithelial barrier function and its underlying mechanism in goats[D].Ph.D.Thesis.Nanjing:Nanjing Agricultural University, 2014.(in Chinese)
[18] MEMON M A, WANG Y, XU T L, et al.Lipopolysaccharide induces oxidative stress by triggering MAPK and Nrf2 signalling pathways in mammary glands of dairy cows fed a high-concentrate diet[J].Microbial Pathogenesis, 2019, 128:268-275.
[19] ZHANG H, PENG A L, ZHAO F F, et al.Thiamine ameliorates inflammation of the ruminal epithelium of Saanen goats suffering from subacute ruminal acidosis[J].Journal of Dairy Science, 2020, 103(2):1931-1943.  
[20] MA Y, ZHANG Y, ZHANG H, et al.Thiamine alleviates high-concentrate-diet-induced oxidative stress, apoptosis, and protects the rumen epithelial barrier function in goats[J].Frontiers in Veterinary Science, 2021, 8:663698.
[21] PLAIZIER J C, KRAUSE D O, GOZHO G N, et al.Subacute ruminal acidosis in dairy cows:the physiological causes, incidence and consequences[J].The Veterinary Journal, 2008, 176(1):21-31.  
[22] 王汉海, 隋美霞.瘤胃异常代谢产物组胺影响反刍动物生产性能和瘤胃性能的研究现状[J].畜牧与兽医, 2016, 48(4):126-128. WANG H H, SUI M X.Research status of rumen abnormal metabolite histamine affecting rumen performance and rumen performance of ruminants[J].Animal Husbandry & Veterinary Medicine, 2016, 48(4):126-128.(in Chinese)
[23] IQBAL S, ZEBELI Q, MAZZOLARI A, et al.Feeding rolled barley grain steeped in lactic acid modulated energy status and innate immunity in dairy cows[J].Journal of Dairy Science, 2010, 93(11):5147-5156.  
[24] STEFANSKA B, CZŁAPA W, PRUSZYNSKA-OSZMAŁEK E, et al.Subacute ruminal acidosis affects fermentation and endotoxin concentration in the rumen and relative expression of the CD14/TLR4/MD2 genes involved in lipopolysaccharide systemic immune response in dairy cows[J].Journal of Dairy Science, 2018, 101(2):1297-1310.  
[25] RODRÍGUEZ-LECOMPTE J C, KROEKER A D, CEBALLOS-MÁRQUEZ A, et al.Evaluation of the systemic innate immune response and metabolic alterations of nonlactating cows with diet-induced subacute ruminal acidosis[J].Journal of Dairy Science, 2014, 97(12):7777-7787.  
[26] FAN W J, LI H P, ZHU H S, et al.NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows[J].Biotechnology Letters, 2016, 38(11):1839-1849.  
[27] SHI X X, LI D D, DENG Q H, et al.NEFAs activate the oxidative stress-mediated NF-κB signaling pathway to induce inflammatory response in calf hepatocytes[J].The Journal of Steroid Biochemistry and Molecular Biology, 2015, 145:103-112.
[28] PARK J, MIN J S, KIM B, et al.Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways[J].Neuroscience Letters, 2015, 584:191-196.
[29] 赵娜, 方慧, 唐亚平, 等.MAPK信号转导通路与慢性牙周炎的相关研究进展[J].口腔医学研究, 2017, 33(9):1012-1015. ZHAO N, FANG H, TANG Y P, etal.Advancement on correction of MAPK signal pathway and chronic periodontitis[J].Journal of Oral Science Research, 2017, 33(9):1012-1015.(in Chinese)
[30] 冯小倩, 武曦, 谭颖徽.组胺及组胺受体的研究进展[J].中华肺部疾病杂志(电子版), 2015, 8(2):88-91. FENG X Q, WU X, TAN Y H.Research progress of histamine and histamine receptor[J].Chinese Journal of Lung Disease(Electronic Edition), 2015, 8(2):88-91.(in Chinese)
[31] 邴新帅.丁酸钠与沙蒿多糖对断奶羔羊肠道发育及胰高血糖素样肽-2的影响[D].硕士学位论文.呼和浩特:内蒙古农业大学, 2018. BING X S.Effect of sodium butyrate and Artemisia seed polysaccharide on intestinal development and glucagon-like peptide-2 of weaning lambs[D].Master's Thesis.Hohhot:Inner Mongolia Agricultural University, 2018.(in Chinese)
[32] ZHANG K, MENG M J, GAO L P, et al.Sodium butyrate improves high-concentrate-diet-induced impairment of ruminal epithelium barrier function in goats[J].Journal of Agricultural and Food Chemistry, 2018, 66(33):8729-8736.  
[33] KOCH C, GERBERT C, FRIETEN D, et al.Effects of ad libitum milk replacer feeding and butyrate supplementation on the epithelial growth and development of the gastrointestinal tract in Holstein calves[J].Journal of Dairy Science, 2019, 102(9):8513-8526.  
[34] MALHI M, GUI H B, YAO L, et al.Increased papillae growth and enhanced short-chain fatty acid absorption in the rumen of goats are associated with transient increases in cyclin D1 expression after ruminal butyrate infusion[J].Journal of Dairy Science, 2013, 96(12):7603-7616.  
[35] SOOMRO J, LU Z Y, GUI H B, et al.Synchronous and time-dependent expression of cyclins, cyclin-dependant kinases, and apoptotic genes in the rumen epithelia of butyrate-infused goats[J].Frontiers in Physiology, 2018, 9:496.
[36] MATHEW O P, RANGANNA K, YATSU F M.Butyrate, an HDAC inhibitor, stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells[J].Biomedicine & Pharmacotherapy, 2010, 64(10):733-740.  
[37] SHERR C J, ROBERTS J M.Living with or without cyclins and cyclin-dependent kinases[J].Genes & Development, 2004, 18(22):2699-2711.  
[38] OGRYZKO V V, WONG P, HOWARD B H.WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases[J].Molecular and Cellular Biology, 1997, 17(8):4877-4882.  
[39] KOWALSKI Z M, GÓRKA P, FLAGA J, et al.Effect of microencapsulated sodium butyrate in the close-up diet on performance of dairy cows in the early lactation period[J].Journal of Dairy Science, 2015, 98(5):3284-3291.  
[40] FUKUMORI R, OBA M, IZUMI K, et al.Effects of butyrate supplementation on blood glucagon-like peptide-2 concentration and gastrointestinal functions of lactating dairy cows fed diets differing in starch content[J].Journal of Dairy Science, 2020, 103(4):3656-3667.  
[41] CANANI R B, COSTANZO M D, LEONE L, et al.Potential beneficial effects of butyrate in intestinal and extraintestinal diseases[J].World Journal of Gastroenterology, 2011, 17(12):1519-1528.  
[42] AGARWAL U, HU Q, BALDWIN R L, et al.Role of rumen butyrate in regulation of nitrogen utilization and urea nitrogen kinetics in growing sheep[J].Journal of Animal Science, 2015, 93(5):2382-2390.  
[43] MA N N, AHAMED A J, BILAL M S, et al.Sodium butyrate improves antioxidant stability in sub-acute ruminal acidosis in dairy goats[J].BMC Veterinary Research, 2018, 14(1):275-288.  
[44] AABDIN Z U, BILAL M S, DAI H Y, et al.NOD1/NF-κB signaling pathway inhibited by sodium butyrate in the mammary gland of lactating goats during sub-acute ruminal acidosis[J].Microbial Pathogenesis, 2018, 122:58-62.
[45] CHANG G J, YAN J Y, MA N N, et al.Dietary sodium butyrate supplementation reduces high-concentrate diet feeding-induced apoptosis in mammary cells in dairy goats[J].Journal of Agricultural and Food Chemistry, 2018, 66(9):2101-2107.  
[46] SHEN H, LU Z Y, XU Z H, et al.Associations among dietary non-fiber carbohydrate, ruminal microbiota and epithelium G-protein-coupled receptor, and histone deacetylase regulations in goats[J].Microbiome, 2017, 5(1):123-135.  
[47] CHANG G J, MA N N, ZHANG H M, et al.Sodium butyrate modulates mucosal inflammation injury mediated by GPR41/43 in the cecum of goats fed a high concentration diet[J].Frontiers in Physiology, 2019, 10:1130-1142.
[48] WANG Y, LIU J, HUANG J, et al.Sodium butyrate attenuated iE-DAP induced inflammatory response in the mammary glands of dairy goats fed high-concentrate diet[J].Journal of the Science of Food and Agriculture, 2021, 101(3):1218-1227.  
[49] DAI H Y, LIU X X, YAN J Y, et al.Sodium butyrate ameliorates high-concentrate diet-induced inflammation in the rumen epithelium of dairy goats[J].Journal of Agricultural and Food Chemistry, 2017, 65(3):596-604.  
[50] CHANG G J, LIU X X, MA N N, et al.Dietary addition of sodium butyrate contributes to attenuated feeding-induced hepatocyte apoptosis in dairy goats[J].Journal of Agricultural and Food Chemistry, 2018, 66(38):9995-10002.  
[51] SETO E, YOSHIDA M.Erasers of histone acetylation:the histone deacetylase enzymes[J].Cold Spring Harbor Perspectives in Biology, 2014, 6(4):a018713.
[52] GARCIA-RAMIREZ M, ROCCHINI C, AUSIO J.Modulation of chromatin folding by histone acetylation[J].Journal of Biological Chemistry, 1995, 270(30):17923-17928.  
[53] SUBRAMANIAN V S, TEAFATILLER T, MORADI H, et al.Histone deacetylase inhibitors regulate vitamin C transporter functional expression in intestinal epithelial cells[J].Journal of Nutritional Biochemistry, 2021, 98:108838.
[54] KASUBUCHI M, HASEGAWA S, HIRAMATSU T, et al.Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation[J].Nutrients, 2015, 7(4):2839-2849.  
[55] SUN X D, LUO S B, JIANG C H, et al.Sodium butyrate reduces bovine mammary epithelial cell inflammatory responses induced by exogenous lipopolysaccharide, by inactivating NF-κB signaling[J].Journal of Dairy Science, 2020, 103(9):8388-8397.  
[56] CHANDRA ROY A, WANG Y, ZHANG H M, et al.Sodium butyrate mitigates iE-DAP induced inflammation caused by high-concentrate feeding in liver of dairy goats[J].Journal of Agricultural and Food Chemistry, 2018, 66(34):8999-9009.  
Outlines

/