REVIEW

Antibacterial Activity of Citrus Essential Oils and Its Mechanism

  • ZHANG Zhuo ,
  • NIE Dechao ,
  • ZHAO Chen ,
  • LI Yanling
Expand
  • College of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China

Received date: 2021-07-12

  Online published: 2022-02-15

Abstract

Citrus essential oils (CEOs) are aromatic compounds extracted from citrus plants. Their main active ingredient is D-limonene, which has a wide range of biological activities, including antibacterial, antioxidant and anti-inflammatory, etc. CEOs have a very important application value in animal production because of their selective antibacterial activity. Different CEOs have different antimicrobial activities, and it is of great significance to study their antimicrobial mechanisms. In this paper, the chemical composition, antibacterial activity and antibacterial mechanism of CEOs were introduced, which laid a foundation for its application in livestock production.

Cite this article

ZHANG Zhuo , NIE Dechao , ZHAO Chen , LI Yanling . Antibacterial Activity of Citrus Essential Oils and Its Mechanism[J]. Chinese Journal of Animal Nutrition, 2022 , 34(2) : 758 -764 . DOI: 10.3969/j.issn.1006-267x.2022.02.010

References

[1] 郝渊鹏, 李静一, 杨瑞, 等.芳香植物精油的抗菌性及在动物生产中的应用[J].植物学报, 2020, 55(5):644-657. HAO Y P, LI J Y, YANG R, et al.Antimicrobial activity of aromatic plant essential oils and their application in animal production[J].Bulletin of Botany, 2020, 55(5):644-657.(in Chinese)
[2] AMBROSIO C M S, IKEDA N Y, MIANO A C, et al.Unraveling the selective antibacterial activity and chemical composition of citrus essential oils[J].Scientific Reports, 2019, 9(1):17719.
[3] 农业农村部.中华人民共和国农业农村部公告 第194号[EB/OL].(2019-07-10)[2021-07-05].http://www.xmsyj.moa.gov.cn/zcjd/201907/t20190710_6320678.htm. Ministry of Agriculture and Rural Affairs of the People's Republic of China.Announcement No.194 of the Ministry of Agriculture and Rural Affairs of the People's Republic of China[EB/OL].(2019-07-10)[2021-07-05].http://www.xmsyj.moa.gov.cn/zcjd/201907/t20190710_6320678.htm.(in Chinese)
[4] AMBROSIO C M S, CONTRERAS-CASTILLO C J, DA GLORIA E M.In vitro mechanism of antibacterial action of a citrus essential oil on an enterotoxigenic Escherichia coli and Lactobacillus rhamnosus[J].Journal of Applied Microbiology, 2020, 129(3):541-553.  
[5] DOSOKY N S, SETZER W N.Biological activities and safety of Citrus spp. essential oils[J].International Journal of Molecular Sciences, 2018, 19(7):1966.
[6] 孙尧, 潘宝宗.柑橘属植物精油在畜牧业生产中的应用[J].上海畜牧兽医通讯, 2020(4):17-19, 21. SUN Y, PAN B Z.Application of citrus essential oil in livestock production[J].Shanghai Journal of Animal Husbandry and Veterinary Medicine, 2020(4):17-19, 21.(in Chinese)
[7] BORA H, KAMLE M, MAHATO D K, et al.Citrus essential oils (CEOs) and their applications in food:an overview[J].Plants, 2020, 9(3):357.
[8] WOLFFENBVTTEL A N, ZAMBONI A, BECKER G, et al.Citrus essential oils inhalation by mice:behavioral testing, GCMS plasma analysis, corticosterone, and melatonin levels evaluation[J].Phytotherapy Research, 2018, 32(1):160-169.  
[9] 陈红丽.柑橘精油的提取与杀菌、杀虫活性研究[D].硕士学位论文.赣州:赣南师范大学, 2017. CHEN H L.Extraction, antimicrobial and insecticidal activities of citrus essential oil[D].Master's Thesis.Ganzhou:Gannan Normal University, 2017.(in Chinese)
[10] MERLE H, MORÓN M, BLÁZQUEZ M A, et al.Taxonomical contribution of essential oils in mandarins cultivars[J].Biochemical Systematics and Ecology, 2004, 32(5):491-497.  
[11] FISHER K, PHILLIPS C.Potential antimicrobial uses of essential oils in food:is citrus the answer?[J].Trends in Food Science & Technology, 2008, 19(3):156-164.  
[12] BAKKALI F, AVERBECK S, AVERBECK D, et al.Biological effects of essential oils-a review[J].Food and Chemical Toxicology, 2008, 46(2):446-475.  
[13] SMITH D C, FORLAND S, BACHANOS E, et al.Qualitative analysis of citrus fruit extracts by GC/MS:an undergraduate experiment[J].The Chemical Educator, 2001, 6(1):28-31.  
[14] MOUFIDA S, MARZOUK B.Biochemical characterization of blood orange, sweet orange, lemon, bergamot and bitter orange[J].Phytochemistry, 2003, 62(8):1283-1289.  
[15] 欧阳秋丽.植物精油典型成分对柑橘果实两种采后致病菌的抑制作用研究[D].博士学位论文.湘潭:湘潭大学, 2018. OUYANG Q L.Inhibitory effects of typical components in plant essential oils against the two postharvest pathogens of citrus fruit[D].Ph.D. Thesis.Xiangtan:Xiangtan University, 2018.(in Chinese)
[16] ANANDAKUMAR P, KAMARAJ S, VANITHA M K.D-limonene:a multifunctional compound with potent therapeutic effects[J].Journal of Food Biochemistry, 2021, 45(1):e13566.
[17] COSTA M D S, ROCHA J E, CAMPINA F F, et al.Comparative analysis of the antibacterial and drug-modulatory effect of d-limonene alone and complexed with β-cyclodextrin[J].European Journal of Pharmaceutical Sciences, 2019, 128:158-161.
[18] SALEHI B, UPADHYAY S, ERDOGAN ORHAN I, et al.Therapeutic potential of α-and β-pinene:a miracle gift of nature[J].Biomolecules, 2019, 9(11):738.
[19] FRANCO-VEGA A, REYES-JURADO F, CARDOSO-UGARTE G A, et al.Sweet orange (Citrus sinensis) oils[M]//PREEDY V R.Essential oils in food preservation, flavor and safety.Pittsburgh:Academic Press, 2016:783-790.
[20] SETTANNI L, PALAZZOLO E, GUARRASI V, et al.Inhibition of foodborne pathogen bacteria by essential oils extracted from citrus fruits cultivated in Sicily[J].Food Control, 2012, 26(2):326-330.  
[21] 任婧楠, 董曼, 范刚, 等.甜橙精油纳米乳液的制备及其抑菌作用研究[J].食品工业科技, 2018, 39(23):80-83, 104. REN J N, DONG M, FAN G, et al.Preparation of sweet orange essential oil nanoemulsions and its antibacterial activity[J].Science and Technology of Food Industry, 2018, 39(23):80-83, 104.(in Chinese)
[22] SINGH P, SHUKLA R, PRAKASH B, et al.Chemical profile, antifungal, antiaflatoxigenic and antioxidant activity of Citrus maxima Burm. and Citrus sinensis (L.) Osbeck essential oils and their cyclic monoterpene, DL-limonene[J].Food and Chemical Toxicology, 2010, 48(6):1734-1740.  
[23] SHARMA N, TRIPATHI A.Effects of Citrus sinensis (L.) Osbeck epicarp essential oil on growth and morphogenesis of Aspergillus niger (L.) Van Tieghem[J].Microbiological Research, 2008, 163(3):337-344.  
[24] VIUDA-MARTOS M, RUIZ-NAVAJAS Y, FERNÁNDEZ-LÓPEZ J, et al.Antifungal activity of lemon (Citrus lemon L.), mandarin (Citrus reticulata L.), grapefruit (Citrus paradisi L.) and orange (Citrus sinensis L.) essential oils[J].Food Control, 2008, 19(12):1130-1138.  
[25] YAZGAN H, OZOGUL Y, KULEY E.Antimicrobial influence of nanoemulsified lemon essential oil and pure lemon essential oil on food-borne pathogens and fish spoilage bacteria[J].International Journal of Food Microbiology, 2019, 306:108266.
[26] OKUNOWO W O, OYEDEJI O, AFOLABI L O, et al.Essential oil of grape fruit (Citrus paradisi) peels and its antimicrobial activities[J].American Journal of Plant Sciences, 2013, 4(7B):1-9.
[27] CHURATA-OROYA D E, RAMOS-PERFECTO D, MOROMI-NAKATA H, et al.Antifungal effect of Citrus paradisi "grapefruit" on strains of Candida albicans isolated from patients with denture stomatitis[J].Revista Estomatológica Herediana, 2016, 26(2):78-84.  
[28] AVILA-SOSA R, NAVARRO-CRUZ A R, SOSA-MORALES M E, et al.Bergamot (Citrus bergamia) oils[M]//PREEDY V R.Essential oils in food preservation, flavor and safety.Pittsburgh:Academic Press, 2016:247-252.
[29] YI F P, JIN R Y, SUN J, et al.Evaluation of mechanical-pressed essential oil from Nanfeng mandarin (Citrus reticulata Blanco cv. Kinokuni) as a food preservative based on antimicrobial and antioxidant activities[J].LWT, 2018, 95:346-353.
[30] STEVIĆ T, BERIĆ T, ŠAVIKIN K, et al.Antifungal activity of selected essential oils against fungi isolated from medicinal plant[J].Industrial Crops and Products, 2014, 55:116-122.
[31] TAO N G, JIA L, ZHOU H E.Anti-fungal activity of Citrus reticulata Blanco essential oil against Penicillium italicum and Penicillium digitatum[J].Food Chemistry, 2014, 153:265-271.
[32] WU T, CHENG D, HE M Y, et al.Antifungal action and inhibitory mechanism of polymethoxylated flavones from Citrus reticulata Blanco peel against Aspergillus niger[J].Food Control, 2014, 35(1):354-359.  
[33] 金如月.柑橘精油的优化提取及活性研究[D].硕士学位论文.上海:上海应用技术大学, 2019. JIN R Y.Study on the optimum extraction and activities of citrus essential oils[D].Master's Thesis.Shanghai:Shanghai Institute of Technology, 2019.(in Chinese)
[34] MARINELLI L, FORNASARI E, EUSEPI P, et al.Carvacrol prodrugs as novel antimicrobial agents[J].European Journal of Medicinal Chemistry, 2019, 178:515-529.
[35] CASTILLO-LÓPEZ R I, GUTIÉRREZ-GRIJALVA E P, LEYVA-LÓPEZ N, et al.Natural alternatives to growth-promoting antibiotics (GPA) in animal production[J].The Journal of Animal & Plant Sciences, 2017, 27(2):349-359.  
[36] ZHANG D, GAN R Y, ZHANG J R, et al.Antivirulence properties and related mechanisms of spice essential oils:a comprehensive review[J].Comprehensive Reviews in Food Science and Food Safety, 2020, 19(3):1018-1055.  
[37] LI Z H, CAI M, LIU Y S, et al.Antibacterial activity and mechanisms of essential oil from Citrus medica L. var. sarcodactylis[J].Molecules, 2019, 24(8):1577.
[38] DENG W H, LIU K, CAO S, et al.Chemical composition, antimicrobial, antioxidant, and antiproliferative properties of grapefruit essential oil prepared by molecular distillation[J].Molecules, 2020, 25(1):217.
[39] SIMITZIS P E.Enrichment of animal diets with essential oils-a great perspective on improving animal performance and quality characteristics of the derived products[J].Medicines, 2017, 4(2):35.
[40] GUO J J, GAO Z P, XIA J L, et al.Comparative analysis of chemical composition, antimicrobial and antioxidant activity of citrus essential oils from the main cultivated varieties in China[J].LWT, 2018, 97:825-839.
[41] NAZZARO F, FRATIANNI F, DE MARTINO L, et al.Effect of essential oils on pathogenic bacteria[J].Pharmaceuticals, 2013, 6(12):1451-1474.  
[42] HELANDER I M, ALAKOMI H L, LATVA-KALA K, et al.Characterization of the action of selected essential oil components on gram-negative bacteria[J].Journal of Agricultural and Food Chemistry, 1998, 46(9):3590-3595.  
[43] VIUDA-MARTOS M, RUIZ-NAVAJAS Y, FERNÁNDEZ-LÓPEZ J, et al.Antibacterial activity of lemon (Citrus lemon L.), mandarin (Citrus reticulata L.), grapefruit (Citrus paradisi L.) and orange (Citrus sinensis L.) essential oils[J].Journal of Food Safety, 2008, 28(4):567-576.  
[44] TANG C L, CHEN J L, ZHANG L X, et al.Exploring the antibacterial mechanism of essential oils by membrane permeability, apoptosis and biofilm formation combination with proteomics analysis against methicillin-resistant Staphylococcus aureus[J].International Journal of Medical Microbiology, 2020, 310(5):151435.
[45] KOHANSKI M A, DWYER D J, COLLINS J J.How antibiotics kill bacteria:from targets to networks[J].Nature Reviews Microbiology, 2010, 8(6):423-435.  
[46] BAJPAI V K, SHARMA A, BAEK K H.Antibacterial mode of action of Cudrania tricuspidata fruit essential oil, affecting membrane permeability and surface characteristics of food-borne pathogens[J].Food Control, 2013, 32(2):582-590.  
[47] SONG X Y, LIU T, WANG L, et al.Antibacterial effects and mechanism of mandarin (Citrus reticulata L.) essential oil against Staphylococcus aureus[J].Molecules, 2020, 25(21):4956.
Outlines

/