RESEARCH PAPER

Growth Promoting Effects of Bacillus congealus BC-HYI on Layer Chickens

  • HU Ting ,
  • LIU Bowen ,
  • ZHANG Hua ,
  • WU Qiong ,
  • ZHOU Bo ,
  • LU Tianhang ,
  • CUI Defeng ,
  • ZHANG Yonghong
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  • 1. Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, College of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China;
    2. College of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China;
    3. China Animal Husbandry Industry Co., Ltd., Beijing 100070, China

Received date: 2021-06-30

  Online published: 2022-02-15

Abstract

This experiment was conducted to explore the growth promoting effects of Bacillus coagulans BC-HYI on layer chickens. The total of 288 one-day-old laying chickens with similar initial weight about 0.55 kg were randomly divided into 4 groups with 6 replicates in each group and 12 chickens in each replicate, including blank group (normal saline 1 mL), BC-HYI low, medium and high dose groups (concentrations of 106, 107, 108 CFU/mL, each 1 mL), continuous gavage for 28 d, blood was collected at weeks 1, 2, 3 and 4 and duodenum, jejunum, ileum and jejunum mucosa were collected. The results showed that compared with the blank group, high dose BC-HYI significantly increased the average daily gain (ADG) and decreased the feed to weight ratio (F/G)of layer chickens at the 4th week (P<0.01); middle dose BC-HYI could significantly increase the ratio of cashmere to cryptic in duodenum, jejunum and ileum of layer chickens (P<0.05); each dose BC-HYI could significantly reduce the serum diamine oxidase (DAO) activity and D-lactic acid (D-Lac) content (P<0.05), and high dose BC-HYI could significantly reduce the content of serum tumor necrosis factor-α (TNF-α) (P<0.01); the mRNA relative expression level of mucin 2 (MUC2), Occludin and zonula occludens protein-1 (ZO-1) in jejunal mucosa significantly increased by medium and high dose of BC-HYI (P<0.01); the contents of secretory immunoglobulin A (SIgA) and interleukin-10 (IL-10) in jejunal mucosa significantly increased by medium dose BC-HYI (P<0.05); three doses of BC-HYI had no significant inhibitory effect on Toll-like receptor 4 (TLR4) signaling pathway in jejunal tissue (P>0.05). In conclusion, Bacillus coagulans BC-HYI can reduce the intestinal mucosal permeability, improve protective effect and absorption function of the intestinal mucosal barrier, reduce the feed to weight ratio and improve the growth performance of layer chickens.

Cite this article

HU Ting , LIU Bowen , ZHANG Hua , WU Qiong , ZHOU Bo , LU Tianhang , CUI Defeng , ZHANG Yonghong . Growth Promoting Effects of Bacillus congealus BC-HYI on Layer Chickens[J]. Chinese Journal of Animal Nutrition, 2022 , 34(2) : 939 -950 . DOI: 10.3969/j.issn.1006-267x.2022.02.026

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