[1] PERINO A,DEMAGNY H,VELAZQUEZ-VILLEGAS L,et al.Molecular physiology of bile acid signaling in health,disease,and aging[J].Physiological Reviews,2021,101(2):683-731.
[2] FOLEY M H,O'FLAHERTY S,ALLEN G,et al.
Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization[J].Proceedings of the National Academy of Sciences of the United States of America,2021,118(6):e2017709118.
[3] JOYCE S A,MACSHARRY J,CASEY P G,et al.Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(20):7421-7426.
[4] JIA W,XIE G X,JIA W P.Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis[J].Nature Reviews.Gastroenterology & Hepatology,2018,15(2):111-128.
[5] KIM G B,MIYAMOTO C M,MEIGHEN E A,et al.Cloning and characterization of the bile salt hydrolase genes (
BSH) from
Bifidobacterium bifidum strains[J].Applied and Environmental Microbiology,2004,70(9):5603-5612.
[6] GOPAL-SRIVASTAVA R,HYLEMON P B.Purification and characterization of bile salt hydrolase from
Clostridium perfringens[J].Journal of Lipid Research,1988,29(8):1079-1085.
[7] GRILL J,SCHNEIDER F,CROCIANI J,et al.Purification and characterization of conjugated bile salt hydrolase from
Bifidobacterium longum BB536[J].Applied and Environmental Microbiology,1995,61(7):2577-2582.
[8] BEGLEY M,HILL C,GAHAN C G M.Bile salt hydrolase activity in probiotics[J].Applied and Environmental Microbiology,2006,72(3):1729-1738.
[9] CHIANG J Y L.Regulation of bile acid synthesis:pathways,nuclear receptors,and mechanisms[J].Journal of Hepatology,2004,40(3):539-551.
[10] RUSSELL D W.The enzymes,regulation,and genetics of bile acid synthesis[J].Annual Review of Biochemistry,2003,72:137-174.
[11] GARCÍA-CAÑAVERAS J C,DONATO M T,CASTELL J V,et al.Targeted profiling of circulating and hepatic bile acids in human,mouse,and rat using a UPLC-MRM-MS-validated method[J].Journal of Lipid Research,2012,53(10):2231-2241.
[12] WANG P,ZHONG H J,SONG Y M,et al.Targeted metabolomics analysis of maternal-placental-fetal metabolism in pregnant swine reveals links in fetal bile acid homeostasis and sulfation capacity[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2019,317(1):G8-G16.
[13] RIDLON J M,KANG D J,HYLEMON P B.Bile salt biotransformations by human intestinal bacteria[J].Journal of Lipid Research,2006,47(2):241-259.
[14] PARASAR B,ZHOU H,XIAO X Y,et al.Chemoproteomic profiling of gut microbiota-associated bile salt hydrolase activity[J].ACS Central Science,2019,5(5):867-873.
[15] SAYIN S I,WAHLSTRÖM A,FELIN J,et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid,a naturally occurring FXR antagonist[J].Cell Metabolism,2013,17(2):225-235.
[16] YAO L N,SEATON S C,NDOUSSE-FETTER S,et al.A selective gut bacterial bile salt hydrolase alters host metabolism[J].eLife,2018,7:e37182.
[17] CHAND D,AVINASH V S,YADAV Y,et al.Molecular features of bile salt hydrolases and relevance in human health[J].Biochimica et Biophysica Acta:General Subjects,2017,1861(1 Pt A):2981-2991.
[18] KIM G B,YI S H,LEE B H.Purification and characterization of three different types of bile salt hydrolases from
Bifidobacterium strains[J].Journal of Dairy Science,2004,87(2):258-266.
[19] COLEMAN J P,HUDSON L L.Cloning and characterization of a conjugated bile acid hydrolase gene from
Clostridium perfringens[J].Applied and Environmental Microbiology,1995,61(7):2514-2520.
[20] TANAKA H,HASHIBA H,KOK J,et al.Bile salt hydrolase of
Bifidobacterium longum-biochemical and genetic characterization[J].Applied and Environmental Microbiology,2000,66(6):2502-2512.
[21] TARANTO M P,SESMA F,DE VALDEZ G F.Localization and primary characterization of bile salt hydrolase from
Lactobacillus reuteri[J].Biotechnology Letters,1999,21(11):935-938.
[22] MOSER S A,SAVAGE D C.Bile salt hydrolase activity and resistance to toxicity of conjugated bile salts are unrelated properties in
Lactobacilli[J].Applied and Environmental Microbiology,2001,67(8):3476-3480.
[23] MCAULIFFE O,CANO R J,KLAENHAMMER T R.Genetic analysis of two bile salt hydrolase activities in
Lactobacillus acidophilus NCFM[J].Applied and Environmental Microbiology,2005,71(8):4925-4929.
[24] DE SMET I,VAN HOORDE L,VANDE WOESTYNE M,et al.Significance of bile salt hydrolytic activities of
Lactobacilli[J].The Journal of Applied Bacteriology,1995,79(3):292-301.
[25] JONES B V,BEGLEY M,HILL C,et al.Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(36):13580-13585.
[26] SONG Z W,CAI Y Y,LAO X Z,et al.Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (
BSH) genes based on worldwide human gut microbiome[J].Microbiome,2019,7(1):9.
[27] BUSTOS A Y,FONT DE VALDEZ G,FADDA S,et al.New insights into bacterial bile resistance mechanisms:the role of bile salt hydrolase and its impact on human health[J].Food Research International,2018,112:250-262.
[28] MARCHESINI M I,CONNOLLY J,DELPINO M V,et al.
Brucella abortus choloylglycine hydrolase affects cell envelope composition and host cell internalization[J].PLoS One,2011,6(12):e28480.
[29] DEAN M,CERVELLATI C,CASANOVA E,et al.Characterization of cholylglycine hydrolase from a bile-adapted strain of
Xanthomonas maltophilia and its application for quantitative hydrolysis of conjugated bile salts[J].Applied and Environmental Microbiology,2002,68(6):3126-3128.
[30] HOLMAN D B,BRUNELLE B W,TRACHSEL J,et al.Meta-analysis to define a core microbiota in the swine gut[J].mSystems,2017,2(3):e00004-17.
[31] BEGLEY M,SLEATOR R D,GAHAN C G M,et al.Contribution of three bile-associated loci,
bsh,
pva,and
btlB,to gastrointestinal persistence and bile tolerance of
Listeria monocytogenes[J].Infection and Immunity,2005,73(2):894-904.
[32] YANG Y,LIU Y R,ZHOU S S,et al.Bile salt hydrolase can improve
Lactobacillus plantarum survival in gastrointestinal tract by enhancing their adhesion ability[J].FEMS Microbiology Letters,2019,366(8):fnz100.
[33] INAGAKI T,MOSCHETTA A,LEE Y K,et al.Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(10):3920-3925.
[34] PESCHEL A.How do bacteria resist human antimicrobial peptides?[J].Trends in Microbiology,2002,10(4):179-186.
[35] PRETE R,LONG S L,GALLARDO A L,et al.Beneficial bile acid metabolism from
Lactobacillus plantarum of food origin[J].Scientific Reports,2020,10(1):1165.
[36] SUN L L,CAI J,GONZALEZ F J.The role of farnesoid X receptor in metabolic diseases,and gastrointestinal and liver cancer[J].Nature Reviews.Gastroenterology & Hepatology,2021,18(5):335-347.
[37] JUNG S,LEE Y J,KIM M,et al.Supplementation with two probiotic strains,
Lactobacillus curvatus HY7601 and
Lactobacillus plantarum KY1032,reduced body adiposity and Lp-PLA2 activity in overweight subjects[J].Journal of Functional Foods,2015,19(Part A):744-752.
[38] KIM M,KIM M,KANG M,et al.Effects of weight loss using supplementation with
Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals[J].Food & Function,2017,8(1):250-261.
[39] JONES M L,MARTONI C J,PARENT M,et al.Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active
Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults[J].The British Journal of Nutrition,2012,107(10):1505-1513.
[40] HUANG F J,ZHENG X J,MA X H,et al.Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism[J].Nature Communications,2019,10(1):4971.
[41] JIANG C T,XIE C,LV Y,et al.Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction[J].Nature Communications,2015,6:10166.
[42] DEGIROLAMO C,RAINALDI S,BOVENGA F,et al.Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice[J].Cell Reports,2014,7(1):12-18.
[43] LIN S,YANG X M,LONG Y R,et al.Dietary supplementation with
Lactobacillus plantarum modified gut microbiota,bile acid profile and glucose homoeostasis in weaning piglets[J].The British Journal of Nutrition,2020,124(8):797-808.
[44] DOSSA A Y,ESCOBAR O,GOLDEN J,et al.Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling[J].American Journal of Physiology.Gastrointestinal and Liver Physiology,2016,310(2):G81-G92.
[45] LIN S,YANG X M,YUAN P Q,et al.Undernutrition shapes the gut microbiota and bile acid profile in association with altered gut-liver FXR signaling in weaning pigs[J].Journal of Agricultural and Food Chemistry,2019,67(13):3691-3701.
[46] SONG M,YANG Q,ZHANG F L,et al.Hyodeoxycholic acid (HDCA) suppresses intestinal epithelial cell proliferation through FXR-PI3K/AKT pathway,accompanied by alteration of bile acids metabolism profiles induced by gut bacteria[J].FASEB Journal,2020,34(5):7103-7117.
[47] SONG M,YE J Y,ZHANG F L,et al.Chenodeoxycholic acid (CDCA) protects against the lipopolysaccharide-induced impairment of the intestinal epithelial barrier function via the FXR-MLCK pathway[J].Journal of Agricultural and Food Chemistry,2019,67(32):8868-8874.
[48] CAMPBELL C,MCKENNEY P T,KONSTANTINOVSKY D,et al.Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells[J].Nature,2020,581(7809):475-479.
[49] HANG S Y,PAIK D,YAO L N,et al.Bile acid metabolites control TH17 and Treg cell differentiation[J].Nature,2019,576(7785):143-148.
[50] SATO Y,ATARASHI K,PLICHTA D R,et al.Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians[J/OL].Nature,2021.(2021-07-29)[2021-08-23].https://doi.org/10.1038/s41586-021-03832-5.DOI:10.1038/s41586-021-03832-5
[51] MULLISH B H,MCDONALD J A K,PECHLIVANIS A,et al.Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent
Clostridioides difficile infection[J].Gut,2019,68(10):1791-1800.
[52] KHODAKIVSKYI P V,LAUBER C L,YEVTODIYENKO A,et al.Noninvasive imaging and quantification of bile salt hydrolase activity:from bacteria to humans[J].Science Advances,2021,7(6):eaaz9857.
[53] 王朋.母猪妊娠期胆汁酸代谢对胎猪存活的影响及其调控[D].博士学位论文.成都:四川农业大学,2020. WANG P.Effects of bile acids metabolism in sows during pregnancy on fetal pigs survival and their regulation[D].Ph.D.Thesis.Chengdu:Sichuan Agricultural University,2020.(in Chinese)
[54] GASKINS H R,COLLIER C T,ANDERSON D B.Antibiotics as growth promotants:mode of action[J].Animal Biotechnology,2002,13(1):29-42.
[55] HU Y,ZHANG Y H,LIU C,et al.Multi-omics profiling highlights lipid metabolism alterations in pigs fed low-dose antibiotics[J].BMC Genetics,2020,21(1):112.
[56] IPHARRAGUERRE I R,PASTOR J J,GAVALDÀ-NAVARRO A,et al.Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling[J].Scientific Reports,2018,8(1):13671.
[57] CHO I,YAMANISHI S,COX L,et al.Antibiotics in early life alter the murine colonic microbiome and adiposity[J].Nature,2012,488(7413):621-626.
[58] GU Y,SONG Y,YIN H,et al.Dietary supplementation with tributyrin prevented weaned pigs from growth retardation and lethal infection via modulation of inflammatory cytokines production,ileal
FGF19 expression,and intestinal acetate fermentation[J].Journal of Animal Science,2017,95(1):226-238.
[59] GENG W J,LONG S L,CHANG Y J,et al.Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system[J].Scientific Reports,2020,10(1):4941.
[60] FEIGHNER S D,DASHKEVICZ M P.Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain,feed efficiency,and bacterial cholyltaurine hydrolase activity[J].Applied and Environmental Microbiology,1987,53(2):331-336.
[61] FEIGHNER S D,DASHKEVICZ M P.Effect of dietary carbohydrates on bacterial cholyltaurine hydrolase in poultry intestinal homogenates[J].Applied and Environmental Microbiology,1988,54(2):337-342.
[62] GUBAN J,KORVER D R,ALLISON G E,et al.Relationship of dietary antimicrobial drug administration with broiler performance,decreased population levels of
Lactobacillus salivarius,and reduced bile salt deconjugation in the ileum of broiler chickens[J].Poultry Science,2006,85(12):2186-2194.
[63] KNARREBORG A,LAURIDSEN C,ENGBERG R M,et al.Dietary antibiotic growth promoters enhance the bioavailability of alpha-tocopheryl acetate in broilers by altering lipid absorption[J].The Journal of Nutrition,2004,134(6):1487-1492.
[64] LIN J,HUNKAPILLER A A,LAYTON A C,et al.Response of intestinal microbiota to antibiotic growth promoters in chickens[J].Foodborne Pathogens and Disease,2013,10(4):331-337.
[65] SMITH K,ZENG X M,LIN J.Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system[J].PLoS One,2014,9(1):e85344.
[66] HEENEY D D,ZHAI Z Y,BENDIKS Z,et al.
Lactobacillus plantarum bacteriocin is associated with intestinal and systemic improvements in diet-induced obese mice and maintains epithelial barrier integrity
in vitro[J].Gut Microbes,2019,10(3):382-397.
[67] SHARIFI S D,DIBAMEHR A,LOTFOLLAHIAN H,et al.Effects of flavomycin and probiotic supplementation to diets containing different sources of fat on growth performance,intestinal morphology,apparent metabolizable energy,and fat digestibility in broiler chickens[J].Poultry Science,2012,91(4):918-927.
[68] RIBOULET-BISSON E,STURME M H J,JEFFERY I B,et al.Effect of
Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota[J].PLoS One,2012,7(2):e31113.
[69] HOU C L,ZENG X F,YANG F J,et al.Study and use of the probiotic
Lactobacillus reuteri in pigs:a review[J].Journal of Animal Science and Biotechnology,2015,6(1):14.
[70] WANG Z,ZENG X M,MO Y M,et al.Identification and characterization of a bile salt hydrolase from
Lactobacillus salivarius for development of novel alternatives to antibiotic growth promoters[J].Applied and Environmental Microbiology,2012,78(24):8795-8802.
[71] JACELA J Y,DEROUCHEY J M,TOKACH M D,et al.Feed additives for swine:fact sheets-high dietary levels of copper and zinc for young pigs,and phytase[J].Journal of Swine Health and Production,2010,18(2):87-91.
[72] SHELTON N W,TOKACH M D,NELSSEN J L,et al.Effects of copper sulfate,tri-basic copper chloride,and zinc oxide on weanling pig performance[J].Journal of Animal Science,2011,89(8):2440-2451.
[73] WAISE T M Z,LIM Y M,DANAEI Z,et al.Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats[J].Molecular Metabolism,2021,44:101132.
[74] STAHLY T S,WILLIAMS N H,LUTZ T R,et al.Dietary B vitamin needs of strains of pigs with high and moderate lean growth[J].Journal of Animal Science,2007,85(1):188-195.
