REVIEW

Regulatory Roles and Mechanisms of CD36 Palmitoylation in Animal Fat Deposition

  • FU Yiming ,
  • LANG Limin ,
  • JIANG Qingyan ,
  • WANG Songbo
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  • UBT Lipid Suite Functional Fatty Acids Research Center, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China

Received date: 2021-08-19

  Online published: 2022-03-14

Abstract

Excessive deposition of animal fat not only reduces the carcass quality, but also is detrimental to animal health. Therefore, regulating animal fat deposition is of great significance to improve the products quality and animal health. CD36, also known as fatty acid translocase, can mediate the transport and uptake of fatty acids, playing vital roles in the regulation of fat deposition. Palmitoylation refers to a kind of protein post-translational modification in which palmitic acid of 16 carbon atoms is combined with amino acid residues of the protein through thioester bonds. Recently, it has been shown that CD36 palmitoylation plays an important regulatory role in fat deposition. Thus, this article mainly reviewed the regulatory effects of CD36 palmitoylation on fat deposition in adipose tissue, heart and liver of animals, and preliminary discussed the possible underlying mechanisms. This review provides reference for further understanding about the regulatory role of palmitoylation in fat deposition and its potential application in animals.

Cite this article

FU Yiming , LANG Limin , JIANG Qingyan , WANG Songbo . Regulatory Roles and Mechanisms of CD36 Palmitoylation in Animal Fat Deposition[J]. Chinese Journal of Animal Nutrition, 2022 , 34(3) : 1456 -1463 . DOI: 10.3969/j.issn.1006-267x.2022.03.010

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