Research Progress of Niacin to Relieve Heat Stress in Ruminants

  • ZOU Bicheng ,
  • LONG Fan ,
  • QU Mingren ,
  • XU Lanjiao
Expand
  • Nutritional Feed Development Engineering Research Center, Jiangxi Provincial Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China

Received date: 2021-09-05

  Online published: 2022-04-14

Abstract

Heat stress is one of the important factors affecting the production of ruminants, and it is easy to harm the health, performance and rumen fermentation function of ruminants. Niacin is one of the essential vitamins for ruminants, that participates in the body's lipid metabolism, promotes vasodilation, reduces body inflammation, and has the effect of relieving heat stress. This article focused on the effects of niacin on performance, blood indicators, and rumen fermentation function of ruminants under heat stress condition. At the same time, it discussed the possible mechanism of niacin to alleviate heat stress.

Cite this article

ZOU Bicheng , LONG Fan , QU Mingren , XU Lanjiao . Research Progress of Niacin to Relieve Heat Stress in Ruminants[J]. Chinese Journal of Animal Nutrition, 2022 , 34(4) : 2130 -2139 . DOI: 10.3969/j.issn.1006-267x.2022.04.009

References

[1] BELLAGI R,MARTIN B,CHASSAING C,et al.Evaluation of heat stress on Tarentaise and Holstein cow performance in the Mediterranean climate[J].International Journal of Biometeorology,2017,61(8):1371-1379.  
[2] MULLER L D,HEINRICHS A J,COOPER J B,et al.Supplemental niacin for lactating cows during summer feeding[J].Journal of Dairy Science,1986,69(5):1416-1420.  
[3] 陈浩,敖日格乐,王纯洁,等.肉牛热应激研究进展[J].中国农业大学学报,2019,24(12):71-77. CHEN H,AO R G L,WANG C J,et al.Research progress on the heat stress of beef cattles[J].Journal of China Agricultural University,2019,24(12):71-77.(in Chinese)
[4] 刘玉强,杨镇玮,赵智锋,等.热应激对肉牛生产影响的研究进展[J].中国草食动物科学,2020,40(5):61-64. LIU Y Q,YANG Z W,ZHAO Z F,et al.Progress on effect of heat stress on beef cattle production[J].China Herbivore Science,2020,40(5):61-64.(in Chinese)
[5] 王伟伟.肉牛热应激的危害及诊治措施[J].畜牧兽医科技信息,2019(1):76. WANG W W.The harm of beef cattle heat stress and its diagnosis and treatment measures[J].Chinese Journal of Animal Husbandry and Veterinary Medicine,2019(1):76.(in Chinese)
[6] 马洪亮.肉牛热应激的危害及其预防方法[J].现代畜牧科技,2019(10):79-80. MA H L.The harm of heat stress in beef cattle and its prevention methods[J].Modern Animal Husbandry Science & Technology,2019(10):79-80.(in Chinese)
[7] SORIANI N,PANELLA G,CALAMARI L.Rumination time during the summer season and its relationships with metabolic conditions and milk production[J].Journal of Dairy Science,2013,96(8):5082-5094.  
[8] KADZERE C T,MURPHY M R,SILANIKOVE N,et al.Heat stress in lactating dairy cows: a review[J].Livestock Production Science,2002,77(1):59-91.  
[9] 马燕芬,陈琦,杜瑞平,等.热应激对奶山羊瘤胃上皮细胞屏障通透性的影响[J].中国农业科学,2013,46(21):4478-4485. MA Y F,CHEN Q,DU R P,et al.Effect of heat stress on rumen epithelial cell barrier permeability in dairy goat[J].Scientia Agricultura Sinica,2013,46(21):4478-4485.(in Chinese)
[10] MCCANN J C,LUAN S Y,CARDOSO F C,et al.Induction of subacute ruminal acidosis affects the ruminal microbiome and epithelium[J].Frontiers in Microbiology,2016,7:701.
[11] PEDERZOLLI R L A,VAN KESSEL A G,CAMPBELL J,et al.Effect of ruminal acidosis and short-term low feed intake on indicators of gastrointestinal barrier function in Holstein steers[J].Journal of Animal Science,2018,96(1):108-125.  
[12] ESLAMIZAD M,LAMP O,DERNO M,et al.The control of short-term feed intake by metabolic oxidation in late-pregnant and early lactating dairy cows exposed to high ambient temperatures[J].Physiology & Behavior,2015,145:64-70.
[13] 吴宇春,褚海燕.烟酸在反刍动物营养中的研究进展[J].饲料博览,2011(8):42-44. WU Y C,CHU H Y.Research progress of nicotinic acid in ruminant nutrition[J].Feed Review,2011(8):42-44.(in Chinese)
[14] 蒋亚军,周凌云,赵芸君,等.烟酸在反刍动物营养中的研究进展[J].中国畜牧兽医,2010,37(7):9-14. JIANG Y J,ZHOU L Y,ZHAO Y J,et al.An overview of niacin as a feed supplement in ruminant production[J].China Animal Husbandry & Veterinary Medicine,2010,37(7):9-14.(in Chinese)
[15] MILLER B L,MEISKE J C,GOODRICH R D.Effects of grain source and concentrate level on B-vitamin production and absorption in steers[J].Journal of Animal Science,1986,62(2):473-483.  
[16] SCHWAB E C,SCHWAB C G,SHAVER R D,et al.Dietary forage and nonfiber carbohydrate contents influence B-vitamin intake,duodenal flow,and apparent ruminal synthesis in lactating dairy cows[J].Journal of Dairy Science,2006,89(1):174-187.  
[17] RUNGRUANG S,COLLIER J L,RHOADS R P,et al.A dose-response evaluation of rumen-protected niacin in thermoneutral or heat-stressed lactating Holstein cows[J].Journal of Dairy Science,2014,97(8):5023-5034.  
[18] SANTSCHI D E,BERTHIAUME R,MATTE J J,et al.Fate of supplementary B-vitamins in the gastrointestinal tract of dairy cows[J].Journal of Dairy Science,2005,88(6):2043-2054.  
[19] ZEITZ J O,WEBER A,MOST E,et al.Effects of supplementing rumen-protected niacin on fiber composition and metabolism of skeletal muscle in dairy cows during early lactation[J].Journal of Dairy Science,2018,101(9):8004-8020.  
[20] NIEHOFF I D,HÜTHER L,LEBZIEN P.Niacin for dairy cattle:a review[J].British Journal of Nutrition,2009,101(1):5-19.
[21] BRENT B E,BARTLEY E E.Thiamin and niacin in the rumen[J].Journal of Animal Science,1984,59(3):813-822.  
[22] ZINN R A,OWENS F N,STUART R L,et al.B-vitamin supplementation of diets for feedlot calves[J].Journal of Animal Science,1987,65(1):267-277.  
[23] ROMANI M,HOFER D C,KATSYUBA E,et al.Niacin:an old lipid drug in a new NAD+ dress[J].Journal of Lipid Research,2019,60(4):741-746.  
[24] KIRKLAND J B,MEYER-FICCA M L.Niacin[J].Advances in Food and Nutrition Research,2018,83:83-149.
[25] 杨耐德,黄晓亮,高振华,等.烟酸对热应激奶牛营养物质表观消化率及血清生化指标的影响[J].中国饲料,2010(12):20-23. YANG N D,HUANG X L,GAO Z H,et al.Effects of dietary niacin supplementation on apparent digestibilities of nutrients and serum biochemical parameter of cows in hot environment[J].China Feed,2010(12):20-23.(in Chinese)
[26] 李萍,梁辛,韦升菊,等.不同水平烟酸对夏季泌乳水牛饲粮养分消化率和生产性能的影响[J].动物营养学报,2014,26(9):2630-2636. LI P,LIANG X,WEI S J,et al.Effects of different niacin supplemental levels on dietary nutrient digestibility and performance of lactating water buffalo in summer[J].Chinese Journal of Animal Nutrition,2014,26(9):2630-2636.(in Chinese)
[27] 王雪莹,王之盛,薛白,等.烟酸对热应激牦牛生长性能、营养物质表观消化率和血液指标的影响[J].动物营养学报,2020,32(5):2228-2240. WANG X Y,WANG Z S,XUE B,et al.Effects of niacin on growth performance,nutrient apparent digestibility and blood indexes of yak under heat-stress[J].Chinese Journal of Animal Nutrition,2020,32(5):2228-2240.(in Chinese)
[28] 许朝芳,杨再云.烟酸对瘤胃微生物代谢的影响[J].中国饲料,2002(22):8-10. XU C F,YANG Z Y.Effect of niacin on microbial metablism of the rumen[J].China Feed,2002(22):8-10.(in Chinese)
[29] 王冠,曲永利,陈勇,等.过瘤胃烟酸对北方奶牛热应激及生产性能的影响[J].黑龙江八一农垦大学学报,2016,28(4):30-35. WANG G,QU Y L,CHEN Y,et al.Effects of rumen-protected niacin on heat stress and performance of dairy cattle in north China[J].Journal of Heilongjiang Bayi Agricultural University,2016,28(4):30-35.(in Chinese)
[30] 陈浩,王纯洁,斯木吉德,等.慢性热应激对放牧肉牛血液生化指标、抗氧化能力及免疫功能的影响[J].中国农业大学学报,2021,26(2):61-69. CHEN H,WANG C J,SI M J D,et al.Effects of chronic heat stress on blood biochemical index,immune function and antioxidant capacity of grazing beef cattle[J].Journal of China Agricultural University,2021,26(2):61-69.(in Chinese)
[31] 张灿,王之盛,彭全辉,等.湿热应激对藏绵羊和山羊生长性能、抗氧化能力以及免疫功能的影响[J].动物营养学报,2017,29(6):2179-2187. ZHANG C,WANG Z S,PENG Q H,et al.Effects of moist-heat stress on growth performance,oxidation resistance and immunity of Tibetan sheep and goats[J].Chinese Journal of Animal Nutrition,2017,29(6):2179-2187.(in Chinese)
[32] WEITZEL J M,VIERGUTZ T,ALBRECHT D,et al.Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows[J].The Journal of Endocrinology,2017,234(2):129-141.  
[33] 李新建,高腾云,孙宇,等.烟酸和烟酸铬对热应激奶牛产奶性能、血液生理生化指标的影响[J].家畜生态学报,2006,27(5):26-31. LI X J,GAO T Y,SUN Y,et al.Effects of niacin and chromium nicotinate on milk performance and blood physiological and biochemical indexes for heat-stressed dairy cows[J].Acta Ecologae Animalis Domastici,2006,27(5):26-31.(in Chinese)
[34] 朱建营,梅洋,李改英,等.弗荷杂交牛与荷斯坦牛热适应性、免疫功能和抗氧化性能比较研究[J].西南师范大学学报(自然科学版),2017,42(4):38-44. ZHU J Y,MEI Y,LI G Y,et al.A comparative study on thermal adaptability,immune function and oxidation resistance of Fleckvieh×Holstein and Holstein cows[J].Journal of Southwest China Normal University(Natural Science Edition),2017,42(4):38-44.(in Chinese)
[35] 李建国,韩永利,李秋凤,等.烟酸对高温环境中奶牛生产性能和血清生化指标的影响[J].动物营养学报,2006,18(3):154-159. LI J G,HAN Y L,LI Q F,et al.Effects of supplemental niacin on performance and serum biochemical parameters of lactating dairy cows in hot environment[J].Chinese Journal of Animal Nutrition,2006,18(3):154-159.(in Chinese)
[36] CHEN S Y,WANG J,PENG D D,et al.Exposure to heat-stress environment affects the physiology,circulation levels of cytokines,and microbiome in dairy cows[J].Scientific Reports,2018,8(1):14606.
[37] ZHANG F J,WENG X G,WANG J F,et al.Effects of temperature-humidity index and chromium supplementation on antioxidant capacity,heat shock protein 72,and cytokine responses of lactating cows[J].Journal of Animal Science,2014,92(7):3026-3034.  
[38] PARK D S,GU B H,PARK Y J,et al.Dynamic changes in blood immune cell composition and function in Holstein and Jersey steers in response to heat stress[J].Cell Stress and Chaperones,2021,26(4):705-720.  
[39] DANGI S S,GUPTA M,NAGAR V,et al.Impact of short-term heat stress on physiological responses and expression profile of HSPs in Barbari goats[J].International Journal of Biometeorology,2014,58(10):2085-2093.  
[40] BHARATI J,DANGI S S,CHOUHAN V S,et al.Expression dynamics of HSP70 during chronic heat stress in Tharparkar cattle[J].International Journal of Biometeorology,2017,61(6):1017-1027.  
[41] 孙先枝,郑楠,卜登攀,等.烟酰胺对热应激奶牛血液中激素、抗氧化能力及免疫功能的影响[J].中国农业大学学报,2014,19(5):101-109. SUN X Z,ZHENG N,BU D P,et al.Effects of nicotinamide on the blood hormone levels,antioxidant status and immune function of cows in heat stress[J].Journal of China Agricultural University,2014,19(5):101-109.(in Chinese)
[42] XIAO Y,RUNGRUANG S,HALL L W,et al.Effects of niacin and betaine on bovine mammary and uterine cells exposed to thermal shock in vitro[J].Journal of Dairy Science,2017,100(5):4025-4037.  
[43] 王灿宇,刘明珠,瞿明仁,等.玉米-豆粕-稻草型日粮中添加烟酸对锦江黄牛瘤胃体外发酵的影响[J].饲料研究,2013(11):50-53. WANG C Y,LIU M Z,QU M R,et al.Effects of adding niacin to corn-soybean meal-straw diets on the rumen fermentation of Jinjiang yellow cattle[J].Feed Research,2013(11):50-53.(in Chinese)
[44] 杨艳,欧阳克蕙,甘兴华,等.不同精粗比日粮中添加烟酸对牛瘤胃体外发酵功能的影响[J].江西农业学报,2021,33(5):76-82. YANG Y,OUYANG K H,GAN X H,et al.Effect of adding nicotinic acid to diets with different concentrate-forage ratios on in vitro rumen fermentation function[J].Acta Agriculturae Jiangxi,2021,33(5):76-82.(in Chinese)
[45] 高雨飞.高精料日粮条件下烟酸对牛瘤胃微生物区系的影响[D].硕士学位论文.南昌:江西农业大学,2016. GAO Y F.Effects of niacin on microorganism system in the rumen of cattle under high-concentrate diet[D].Master’s Thesis.Nanchang:Jiangxi Agricultural University,2016.(in Chinese)
[46] 林波,梁辛,韦升菊,等.烟酸对水牛瘤胃发酵指标及微生物区系的影响[J].动物营养学报,2015,27(8):2396-2404. LIN B,LIANG X,WEI S J,et al.Effects of niacin on ruminal fermentation indexes and microflora of water buffaloes[J].Chinese Journal of Animal Nutrition,2015,27(8):2396-2404.(in Chinese)
[47] 李萍.日粮添加烟酸和日粮精粗比对奶水牛生产性能、瘤胃发酵和纤维降解菌数的影响[D].硕士学位论文.南宁:广西大学,2014. LI P.Effects of adding niacin to diet and dietary concentrates to roughage ratio on milk performance,rumen fermentation and rumen cellulolytic bacterium in dairy buffalo[D].Master’s Thesis.Nanning:Guangxi University,2014.(in Chinese)
[48] RUSSELL J B,MUCK R E,WEIMER P J.Quantitative analysis of cellulose degradation and growth of cellulolytic bacteria in the rumen[J].FEMS Microbiology Ecology,2009,67(2):183-197.  
[49] 崔浩然,郭雪峰,金巍.反刍动物瘤胃微生物菌群结构影响因素的研究进展[J].中国畜牧杂志,2021,57(11):6-11. CUI H R,GUO X F,JIN W.Research progress on factors affecting rumen microbial flora structure[J].Chinese Journal of Animal Science,2021,57(11):6-11.(in Chinese)
[50] KAMANNA V S,GANJI S H,KASHYAP M L.The mechanism and mitigation of niacin-induced flushing[J].International Journal of Clinical Practice,2009,63(9):1369-1377.  
[51] KHAN N,KEWALRAMANI N,KANT K.Niacin supplementation for lactating cows under heat stress conditions-a review[J].Agricultural Reviews,2012,33(2):143-149.
[52] SWANSON R M,TAIT R G,GALLES B M,et al.Heat stress-induced deficits in growth,metabolic efficiency,and cardiovascular function coincided with chronic systemic inflammation and hypercatecholaminemia in ractopamine-supplemented feedlot lambs[J].Journal of Animal Science,2020,98(6):skaa168.
[53] MARTIN C,MICHALET-DOREAU B,FONTY G,et al.Postprandial variations in the activity of polysaccharide-degrading enzymes of fluid- and particle-associated ruminal microbial populations[J].Current Microbiology,1993,27(4):223-228.  
[54] MEYERS C D,KAMANNA V S,KASHYAP M L.Niacin therapy in atherosclerosis[J].Current Opinion in Lipidology,2004,15(6):659-665.  
[55] CARLSON L A.Nicotinic acid:the broad-spectrum lipid drug.A 50th anniversary review[J].Journal of Internal Medicine,2005,258(2):94-114.  
[56] 张心壮,曹迪,格日乐其木格,等.畜禽生产中氧化应激分子调控机理及营养策略研究进展[J].畜牧与饲料科学,2021,42(4):29-36. ZHANG X Z,CAO D,GE R L Q M G,et al.Research advances on molecular regulatory mechanisms of oxidative stress and nutritional strategies in livestock and poultry production[J].Animal Husbandry and Feed Science,2021,42(4):29-36.(in Chinese)
[57] 刘宇宸,王向明,万平民,等.热应激引起动物炎症反应的研究进展[J].中国兽医杂志,2019,55(3):57-60,8. LIU Y C,WANG X M,WAN P M,et al.Research progress on heat stress-induced inflammatory response in animals[J].Chinese Journal of Veterinary Medicine,2019,55(3):57-60,8.(in Chinese)
[58] 陆灿强,舒邓群,臧一天.热应激诱导畜禽氧化应激、热休克反应与免疫和炎症反应的机制及营养调控措施[J].动物营养学报,2021,33(6):3115-3124. LU C Q,SHU D Q,ZANG Y T.Mechanism and nutritional regulation of oxidative stress,heat shock response,immunity and inflammation induced by heat stress in livestock and poultry[J].Chinese Journal of Animal Nutrition,2021,33(6):3115-3124.(in Chinese)
[59] BARRETT N W,ROWLAND K,SCHMIDT C J,et al.Effects of acute and chronic heat stress on the performance,egg quality,body temperature,and blood gas parameters of laying hens[J].Poultry Science,2019,98(12):6684-6692.  
[60] 恒景会,田敏,管武太,等.氧化应激对母畜乳腺功能的影响及其营养调控策略[J].动物营养学报,2020,32(12):5587-5595. HENG J H,TIAN M,GUAN W T,et al.Effects of oxidative stress on mammary gland function of female animals and its nutritional regulation strategy[J].Chinese Journal of Animal Nutrition,2020,32(12):5587-5595.(in Chinese)
[61] NAWAB A,AN L L,WU J,et al.Chicken toll-like receptors and their significance in immune response and disease resistance[J].International Reviews of Immunology,2019,38(6):284-306.  
[62] VIDYA M K,KUMAR V G,SEJIAN V,et al.Toll-like receptors:significance,ligands,signaling pathways,and functions in mammals[J].International Reviews of Immunology,2018,37(1):20-36.  
[63] 魏小林,谢敏.NALP3炎性复合体与MAPK、NF-κB及ROS信号通路之间的关系[J].国际呼吸杂志,2015,35(6):476-480. WEI X L,XIE M.Relationship between NALP3 inflammasome and MAPK,NF-κB,ROS signal pathway[J].International Journal of Respiration,2015,35(6):476-480.(in Chinese)
[64] 阎辉,毛湘冰,余冰,等.基于生猪疾病模型探讨营养对免疫的调控作用[J].动物营养学报,2020,32(10):4471-4479. YAN H,MAO X B,YU B,et al.Nutritional regulation on immunity based on pig disease model[J].Chinese Journal of Animal Nutrition,2020,32(10):4471-4479.(in Chinese)
[65] MARTINON F.Signaling by ROS drives inflammasome activation[J].European Journal of Immunology,2010,40(3):616-619.  
[66] 高婷,王子旭,陈祝茗,等.ROS介导的氧化应激与自噬[J].中国畜牧兽医,2018,45(3):656-662. GAO T,WANG Z X,CHEN Z M,et al.Oxidative stress and autophagy mediated by reactive oxygen species[J].China Animal Husbandry & Veterinary Medicine,2018,45(3):656-662.(in Chinese)
[67] CHEN T H,WANG J J.Niacin pretreatment attenuates ischemia and reperfusion of pancreas-induced acute pancreatitis and remote lung injury through suppressing oxidative stress and inflammation and activation of SIRT1[J].Transplantation Proceedings,2018,50(9):2860-2863.  
[68] CHO K H,KIM H J,RODRIGUEZ-ITURBE B,et al.Niacin ameliorates oxidative stress,inflammation,proteinuria,and hypertension in rats with chronic renal failure[J].American Journal of Physiology.Renal Physiology,2009,297(1):F106-F113.
[69] GANJI S H,QIN S C,ZHANG L H,et al.Niacin inhibits vascular oxidative stress,redox-sensitive genes,and monocyte adhesion to human aortic endothelial cells[J].Atherosclerosis,2009,202(1):68-75.  
[70] SI Y H,ZHANG Y,ZHAO J L,et al.Niacin inhibits vascular inflammation via downregulating nuclear transcription factor-κB signaling pathway[J].Mediators of Inflammation,2014,2014:263786.
[71] SALMINEN A,KAARNIRANTA K,KAUPPINEN A.Crosstalk between oxidative stress and SIRT1:impact on the aging process[J].International Journal of Molecular Sciences,2013,14(2):3834-3859.  
[72] SAHEBKAR A.Effect of niacin on endothelial function:a systematic review and meta-analysis of randomized controlled trials[J].Vascular Medicine,2014,19(1):54-66.  
[73] KWON W Y,SUH G J,KIM K S,et al.Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-κB pathway[J].Critical Care Medicine,2011,39(2):328-334.  
[74] GANJI S H,QIN S C,LIU T J,et al.Niacin inhibits LDL oxidation and redox-sensitive VCAM-1 and MCP-1 expression in human aortic endothelial cells[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2004,24(5):E-125.
[75] MONTSERRAT-DE LA PAZ S,NARANJO M C,LOPEZ S,et al.Niacin and its metabolites as master regulators of macrophage activation[J].The Journal of Nutritional Biochemistry,2017,39:40-47.
[76] KARUNARATNE T B,OKEREKE C,SEAMON M,et al.Niacin and butyrate:nutraceuticals targeting dysbiosis and intestinal permeability in parkinson’s disease[J].Nutrients,2020,13(1):28.
[77] WU B J,CHEN K,BARTER P J,et al.Niacin inhibits vascular inflammation via the induction of heme oxygenase-1[J].Circulation,2012,125(1):150-158.  
[78] GUO W J,LIU J X,LI W,et al.Niacin alleviates dairy cow mastitis by regulating the GPR109A/AMPK/NRF2 signaling pathway[J].International Journal of Molecular Sciences,2020,21(9):3321.
Outlines

/