Metabolic Pathways and Application Research of Arginine in Animal Husbandry Production

  • LI Shuai ,
  • WANG Li ,
  • LIANG Xingwei ,
  • XIAO Hao
Expand
  • 1. Guangdong Key Laboratory of Animal Breeding and Nutrition, Lingnan Modern Agricultural Science and Technology Maoming Sub-Center of Guangdong Provincial Laboratory, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
    2. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China

Received date: 2021-09-27

  Online published: 2022-04-14

Abstract

Arginine is a multifunctional semi-essential or conditionally essential basic amino acid.It is an essential amino acid for young mammals. It plays an important role in muscle protein synthesis, intestinal immune regulation, wound repair and other physiological processes. This paper reviews the transport mechanism, arginine sensor, synthesis and catabolism mechanism of arginine, expounds the research progress of arginine and its products in animal husbandry production, and discusses its role in the growth, stress relief and immune metabolism of livestock and poultry. It provides a theoretical reference for the scientific and rational application of arginine in compound feed for livestock and poultry.

Cite this article

LI Shuai , WANG Li , LIANG Xingwei , XIAO Hao . Metabolic Pathways and Application Research of Arginine in Animal Husbandry Production[J]. Chinese Journal of Animal Nutrition, 2022 , 34(4) : 2156 -2166 . DOI: 10.3969/j.issn.1006-267x.2022.04.012

References

[1] BROSNAN M E,BROSNAN J T.Renal arginine metabolism[J].The Journal of Nutrition,2004,134(Suppl.10):2791S-2795S.
[2] CLOSS E I,BOISSEL J P,HABERMEIER A,et al.Structure and function of cationic amino acid transporters (CATs)[J].The Journal of Membrane Biology,2006,213(2):67-77.  
[3] SLOAN J L,MAGER S.Cloning and functional expression of a human Na+ and Cl--dependent neutral and cationic amino acid transporter B0+[J].Journal of Biological Chemistry,1999,274(34):23740-23745.  
[4] CLOSS E I,SIMON A,VÉKONY N,et al.Plasma membrane transporters for arginine[J].The Journal of Nutrition,2004,134(Suppl.10):2752S-2759S.
[5] FOTIADIS D,KANAI Y,PALACÍN M.The SLC3 and SLC7 families of amino acid transporters[J].Molecular Aspects of Medicine,2013,34(2/3):139-158.
[6] STEVENS B R,KAKUDA D K,YU K,et al.Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes[J].Journal of Biological Chemistry,1996,271(39):24017-24022.  
[7] SAXTON R A,SABATINI D M.mTOR signaling in growth,metabolism,and disease[J].Cell,2017,169(2):361-371.
[8] CHANTRANUPONG L,SCARIA S M,SAXTON R A,et al.The CASTOR proteins are arginine sensors for the mTORC1 pathway[J].Cell,2016,165(1):153-164.  
[9] JUNG J,GENAU H M,BEHRENDS C.Amino acid-dependent mTORC1 regulation by the lysosomal membrane protein SLC38A9[J].Molecular and Cellular Biology,2015,35(14):2479-2494.  
[10] WANG S Y,TSUN Z Y,WOLFSON R L,et al.Metabolism.Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1[J].Science,2015,347(6218):188-194.  
[11] WYANT G A,ABU-REMAILEH M,WOLFSON R L,et al.mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient[J].Cell,2017,171(3):642-654.e12.  
[12] LEI H T,MA J M,SANCHEZ MARTINEZ S,et al.Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state[J].Nature Structural & Molecular Biology,2018,25(6):522-527.  
[13] SHEN K,SABATINI D M.Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms[J].Proceedings of the National Academy of Sciences of the United States of America,2018,115(38):9545-9550.  
[14] KIMBALL S R,ANTHONY T,ZHANG P.The eIF2α kinase GCN2 is activated in mouse liver by imbalanced mixtures of dietary essential amino acids[J].The FASEB Journal,2002,16:A789.
[15] DEVAL C,CHAVEROUX C,MAURIN A C,et al.Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways[J].The FEBS Journal,2009,276(3):707-718.  
[16] WU G,DAVIS P K,FLYNN N E,et al.Endogenous synthesis of arginine plays an important role in maintaining arginine homeostasis in postweaning growing pigs[J].The Journal of Nutrition,1997,127(12):2342-2349.  
[17] WATFORD M.The urea cycle:a two-compartment system[J].Essays in Biochemistry,1991,26:49-58.
[18] RHOADS J M,PLUNKETT E,GALANKO J,et al.Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndrome[J].The Journal of Pediatrics,2005,146(4):542-547.  
[19] WU G,KNABE D A.Arginine synthesis in enterocytes of neonatal pigs[J].The American Journal of Physiology,1995,269(3Pt.2):R621-R629.
[20] WINDMUELLER H G,SPAETH A E.Source and fate of circulating citrulline[J].The American Journal of Physiology,1981,241(6):E473-E480.
[21] WU G,BORBOLLA A G,KNABE D A.The uptake of glutamine and release of arginine,citrulline and proline by the small intestine of developing pigs[J].The Journal of Nutrition,1994,124(12):2437-2444.  
[22] MURPHY J M,MURCH S J,BALL R O.Proline is synthesized from glutamate during intragastric infusion but not during intravenous infusion in neonatal piglets[J].Journal of Nutrition,1996,126(4):878-886.  
[23] WU G Y,BAZER F W,DAVIS T A,et al.Arginine metabolism and nutrition in growth,health and disease[J].Amino Acids,2009,37(1):153-168.  
[24] WU G Y,KNABE D A,KIM S W.Arginine nutrition in neonatal pigs[J].The Journal of Nutrition,2004,134(Suppl.10):2783S-2790S.
[25] HU C A A,KHALIL S,ZHAORIGETU S,et al.Human Δ1-pyrroline-5-carboxylate synthase:function and regulation[J].Amino Acids,2008,35(4):665-672.  
[26] MORRIS S M,Jr,SWEENEY W E,Jr,KEPKA D M,et al.Localization of arginine biosynthetic enzymes in renal proximal tubules and abundance of mRNA during development[J].Pediatric Research,1991,29(2):151-154.  
[27] LI P,MAI K S,TRUSHENSKI J,et al.New developments in fish amino acid nutrition:towards functional and environmentally oriented aquafeeds[J].Amino Acids,2009,37(1):43-53.  
[28] WU G Y,BAZER F W,CUDD T A,et al.Pharmacokinetics and safety of arginine supplementation in animals[J].The Journal of Nutrition,2007,137(Suppl.2):1673S-1680S.
[29] RATH M,MÜLLER I,KROPF P,et al.Metabolism via arginase or nitric oxide synthase:two competing arginine pathways in macrophages[J].Frontiers in Immunology,2014,5:532.
[30] LI H,MEININGER C J,KELLY K A,et al.Activities of arginase Ⅰ and Ⅱ are limiting for endothelial cell proliferation[J].American Journal of Physiology.Regulatory,Integrative and Comparative Physiology,2002,282(1):R64-R69.
[31] ODENLUND M,HOLMQVIST B,BALDETORP B,et al.Polyamine synthesis inhibition induces S phase cell cycle arrest in vascular smooth muscle cells[J].Amino Acids,2009,36(2):273-282.  
[32] KEPKA-LENHART D,MISTRY S K,WU G,et al.Arginase Ⅰ:a limiting factor for nitric oxide and polyamine synthesis by activated macrophages?[J].American Journal of Physiology.Regulatory,Integrative and Comparative Physiology,2000,279(6):R2237-R2242.
[33] WEI L H,WU G,MORRIS S M,Jr,et al.Elevated arginase Ⅰ expression in rat aortic smooth muscle cells increases cell proliferation[J].Proceedings of the National Academy of Sciences of the United States of America,2001,98(16):9260-9264.  
[34] CORRALIZA I M,SOLER G,EICHMANN K,et al.Arginase induction by suppressors of nitric oxide synthesis (IL-4,IL-10 and PGE2) in murine bone-marrow-derived macrophages[J].Biochemical and Biophysical Research Communications,1995,206(2):667-673.  
[35] PAULEAU A L,RUTSCHMAN R,LANG R,et al.Enhancer-mediated control of macrophage-specific arginase Ⅰ expression[J].Journal of Immunology,2004,172(12):7565-7573.  
[36] ERDELY A,KEPKA-LENHART D,CLARK M,et al.Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages[J].American Journal of Physiology.Lung Cellular and Molecular Physiology,2006,290(3):L534-L539.
[37] SHELDON K E,SHANDILYA H,KEPKA-LENHART D,et al.Shaping the murine macrophage phenotype:IL-4 and cyclic AMP synergistically activate the arginase Ⅰ promoter[J].Journal of Immunology,2013,191(5):2290-2298.  
[38] STUEHR D J,MARLETTA M A.Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection,lymphokines,or interferon-gamma[J].Journal of Immunology,1987,139(2):518-525.
[39] STUEHR D J,MARLETTA M A.Mammalian nitrate biosynthesis:mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide[J].Proceedings of the National Academy of Sciences of the United States of America,1985,82(22):7738-7742.  
[40] HIBBS J B,Jr,TAINTOR R R,VAVRIN Z.Macrophage cytotoxicity:role for L-arginine deiminase and imino nitrogen oxidation to nitrite[J].Science,1987,235(4787):473-476.  
[41] MACMICKING J,XIE Q W,NATHAN C.Nitric oxide and macrophage function[J].Annual Review of Immunology,1997,15:323-350.
[42] BREDT D S,HWANG P M,GLATT C E,et al.Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase[J].Nature,1991,351(6329):714-718.  
[43] XIE Q W,CHO H J,CALAYCAY J,et al.Cloning and characterization of inducible nitric oxide synthase from mouse macrophages[J].Science,1992,256(5054):225-228.  
[44] LYONS C R,ORLOFF G J,CUNNINGHAM J M.Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line[J].Journal of Biological Chemistry,1992,267(9):6370-6374.  
[45] MODOLELL M,CORRALIZA I M,LINK F,et al.Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines[J].European Journal of Immunology,1995,25(4):1101-1104.  
[46] IGNARRO L J.Biosynthesis and metabolism of endothelium-derived nitric oxide[J].Annual Review of Pharmacology and Toxicology,1990,30:535-560.
[47] HECKER M,NEMATOLLAHI H,HEY C,et al.Inhibition of arginase by NG-hydroxy-L-arginine in alveolar macrophages:implications for the utilization of L-arginine for nitric oxide synthesis[J].FEBS Letters,1995,359(2/3):251-254.
[48] BAUER P M,FUKUTO J M,BUGA G M,et al.Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation[J].Biochemical and Biophysical Research Communications,1999,262(2):355-358.  
[49] SOUTHAN G J,SZABO C,THIEMERMANN C.Inhibition of the induction of nitric oxide synthase by spermine is modulated by aldehyde dehydrogenase[J].Biochemical and Biophysical Research Communications,1994,203(3):1638-1644.  
[50] BUSSIÈRE F I,CHATURVEDI R,CHENG Y L,et al.Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation[J].Journal of Biological Chemistry,2005,280(4):2409-2412.  
[51] YAO K,GUAN S,LI T J,et al.Dietary L-arginine supplementation enhances intestinal development and expression of vascular endothelial growth factor in weanling piglets[J].British Journal of Nutrition,2011,105(5):703-709.  
[52] WU X,RUAN Z,GAO Y L,et al.Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet[J].Amino Acids,2010,39(3):831-839.  
[53] NUNTAPAITOON M,MUNS R,THEIL P K,et al.L-arginine supplementation in sow diet during late gestation decrease stillborn piglet,increase piglet birth weight and increase immunoglobulin G concentration in colostrum[J].Theriogenology,2018,121:27-34.
[54] TAN B,YIN Y L,LIU Z Q,et al.Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs[J].Amino Acids,2009,37(1):169-175.  
[55] TAN J Z,APPLEGATE T J,LIU S S,et al.Supplemental dietary L-arginine attenuates intestinal mucosal disruption during a coccidial vaccine challenge in broiler chickens[J].British Journal of Nutrition,2014,112(7):1098-1109.  
[56] RHOADS J M,CHEN W,GOOKIN J,et al.Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism[J].Gut,2004,53(4):514-522.  
[57] WANG J,LI G R,TAN B E,et al.Oral administration of putrescine and proline during the suckling period improves epithelial restitution after early weaning in piglets[J].Journal of Animal Science,2015,93(4):1679-1688.  
[58] ISHIKAWA T,HARADA T,KOI H,et al.Identification of arginase in human placental villi[J].Placenta,2007,28(2/3):133-138.
[59] WU G,BAZER F W,WALLACE J M,et al.Board-invited review:intrauterine growth retardation: implications for the animal sciences[J].Journal of Animal Science,2006,84(9):2316-2337.  
[60] WU G,BAZER F W,CUDD T A,et al.Maternal nutrition and fetal development[J].Early Human Development,1980,4(2):99-120.  
[61] ZHANG Y F,YANG J Y,MENG X P,et al.L-arginine protects against T-2 toxin-induced male reproductive impairments in mice[J].Theriogenology,2019,126:249-253.
[62] LENDE T,KNOL E F,LEENHOUWERS J I.Prenatal development as predisposing factor for perinatal losses in pigs[J].Reproduction (Cambridge, England) Supplement,2001,58:247-261.
[63] LASSALA A,BAZER F W,CUDD T A,et al.Parenteral administration of L-arginine enhances fetal survival and growth in sheep carrying multiple fetuses[J].The Journal of Nutrition,2011,141(5):849-855.  
[64] HONG J S,FANG L H,JEONG J H,et al.Effects of L-arginine supplementation during late gestation on reproductive performance,piglet uniformity,blood profiles,and milk composition in high prolific sows[J].Animals,2020,10(8):1313.
[65] YI H B,XIONG Y X,WU Q W,et al.Effects of dietary supplementation with l-arginine on the intestinal barrier function in finishing pigs with heat stress[J].Journal of Animal Physiology and Animal Nutrition,2020,104(4):1134-1143.  
[66] HE Q H,TANG H R,REN P P,et al.Dietary supplementation with l-arginine partially counteracts serum metabonome induced by weaning stress in piglets[J].Journal of Proteome Research,2011,10(11):5214-5221.  
[67] WILEMAN S M,MANN G E,BAYDOUN A R.Induction of L-arginine transport and nitric oxide synthase in vascular smooth muscle cells:synergistic actions of pro-inflammatory cytokines and bacterial lipopolysaccharide[J].British Journal of Pharmacology,1995,116(8):3243-3250.  
[68] LUIKING Y C,POEZE M,RAMSAY G,et al.The role of arginine in infection and sepsis[J].Journal of Parenteral and Enteral Nutrition,2005,29(1 Suppl):S70-S74.
[69] XIAO H,ZENG L M,SHAO F Y,et al.The role of nitric oxide pathway in arginine transport and growth of IPEC-1 cells[J].Oncotarget,2017,8(18):29976-29983.  
[70] TAN B,XIAO H,XIONG X,et al.L-arginine improves DNA synthesis in LPS-challenged enterocytes[J].Frontiers in Bioscience (Landmark Edition),2015,20:989-1003.
[71] RUAN D,FOUAD A M,FAN Q L,et al.Dietary L-arginine supplementation enhances growth performance,intestinal antioxidative capacity,immunity and modulates gut microbiota in yellow-feathered chickens[J].Poultry Science,2020,99(12):6935-6945.  
[72] CORL B A,ODLE J,NIU X M,et al.Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis[J].The Journal of Nutrition,2008,138(1):24-29.  
[73] LAIKA M,JAHANIAN R.Increase in dietary arginine level could ameliorate detrimental impacts of coccidial infection in broiler chickens[J].Livestock Science,2017,195:38-44.
[74] SALAMA A A K,DUQUE M,WANG L,et al.Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins,messenger RNA,and microRNA abundance in heat-stressed bovine mammary epithelial cells in vitro[J].Journal of Dairy Science,2019,102(3):2469-2480.  
[75] ZHANG H,PENG A L,YU Y,et al.L-arginine protects ovine intestinal epithelial cells from lipopolysaccharide-induced apoptosis through alleviating oxidative stress[J].Journal of Agricultural and Food Chemistry,2019,67(6):1683-1690.  
[76] ORLANDO G F,WOLF G,ENGELMANN M.Role of neuronal nitric oxide synthase in the regulation of the neuroendocrine stress response in rodents:insights from mutant mice[J].Amino Acids,2008,35(1):17-27.  
[77] WU M M,XIAO H,SHAO F Y,et al.Arginine accelerates intestinal health through cytokines and intestinal microbiota[J].International Immunopharmacology,2020,81:106029.
[78] BRONTE V,ZANOVELLO P.Regulation of immune responses by L-arginine metabolism[J].Nature Reviews Immunology,2005,5(8):641-654.  
[79] ZHU H L,LIU Y L,XIE X L,et al.Effect of L-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge[J].Innate Immunity,2013,19(3):242-252.  
[80] HAN J,LIU Y L,FAN W,et al.Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs[J].Amino Acids,2009,37(4):643-651.  
Outlines

/