[1] KUMARI R,KUMAR S,KUMAR A,et al.Antibacterial,antioxidant and immuno-modulatory properties in extracts of
Barleria lupulina Lindl[J].BMC Complementary and Alternative Medicine,2017,17(1):484.
[2] 卢猛,胡凤明,屠焰,等.植物提取物对幼龄动物腹泻和肠道健康的作用[J].饲料工业,2021,42(15):35-42. LU M,HU F M,TU Y,et al.Effects of plant extracts on diarrhea and intestinal health of young animals[J].Feed Industry,2021,42(15):35-42.(in Chinese)
[3] ZUO A R,DONG H H,YU Y Y,et al.The antityrosinase and antioxidant activities of flavonoids dominated by the number and location of phenolic hydroxyl groups[J].Chinese Medicine,2018,13:51.
[4] KALPANA K B,SRINIVASAN M,MENON V P.Evaluation of antioxidant activity of hesperidin and its protective effect on H
2O
2 induced oxidative damage on pBR322 DNA and RBC cellular membrane[J].Molecular and Cellular Biochemistry,2009,323(1/2):21-29.
[5] YEH C C,KAO S J,LIN C C,et al.The immunomodulation of endotoxin-induced acute lung injury by hesperidin
in vivo and
in vitro[J].Life Sciences,2007,80(20):1821-1831.

[6] GUO K,REN J A,GU G S,et al.Hesperidin protects against intestinal inflammation by restoring intestinal barrier function and up-regulating Treg cells[J].Molecular Nutrition & Food Research,2019,63(11):e1800975.
[7] 汪晓辉,郭溶,聂晓彬,等.佛手抗菌活性及其药效成分橙皮苷对金黄色葡萄球菌的作用机制研究[J].中国抗生素杂志,2021,46(5):437-441. WANG X H,GUO R,NIE X B,et al.Antibacterial activity of
Citri Sarcodactylis Fructus and its antibacterial mechanism against
Staphylococcus aureus[J].Chinese Journal of Antibiotics,2021,46(5):437-441.(in Chinese)
[8] 孙峋,汪靖超,李洪涛,等.迷迭香酸的抗菌机理研究[J].青岛大学学报(自然科学版),2005,18(4):41-45. SUN X,WANG J C,LI H T,et al.A study on the antibacterial mechanism of rosmarinic acid[J].Journal of Qingdao University (Natural Science Edition),2005,18(4):41-45.(in Chinese)
[9] ZDARILOVÁ A,SVOBODOVÁ A,SIMÁNEK V,et al.
Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts[J].Toxicology
in Vitro,2009,23(3):386-392.

[10] DE OLIVEIRA FORMIGA R,ALVES J ÚNIOR E B,VASCONCELOS R C,et al.p-cymene and rosmarinic acid ameliorate TNBS-induced intestinal inflammation upkeeping
ZO-1 and MUC-2:role of antioxidant system and immunomodulation[J].International Journal of Molecular Sciences,2020,21(16):5870.
[11] KARTHIKKUMAR V,SIVAGAMI G,VISWANATHAN P,et al.Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats[J].Journal of Basic and Clinical Physiology and Pharmacology,2015,26(2):185-200.
[12] MULLANE K M,KRAEMER R,SMITH B.Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium[J].Journal of Pharmacological Methods,1985,14(3):157-167.

[13] 张风亭,胡坦,潘思轶.橙皮苷生物学活性及其改性技术的研究进展[J/OL].食品工业科技:1-12. ZHANG F T,HU T,PAN S Y.Research progress on biological activity and modification technology of hesperidin[J/OL].Science and Technology of Food Industry:1-12. (in Chinese)
[14] GROHMANN K,MANTHEY J A,CAMERON R G.Acid-catalyzed hydrolysis of hesperidin at elevated temperatures[J].Carbohydrate Research,2000,328(2):141-146.

[15] COHEN J.The immunopathogenesis of sepsis[J].Nature,2002,420(6917):885-891.

[16] ZOETENDAL E G,AKKERMANS A D,DE VOS W M.Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria[J].Applied & Environmental Microbiology,1998,64(10):3854-3859.

[17] ZHU Y Z,NIU Q Y,SHI C,et al.The role of microbiota in compensatory growth of protein-restricted rats[J].Microbial Biotechnology,2017,10(2):480-491.

[18] WANG J,TIAN S Y,YU H,et al.Response of colonic mucosa-associated microbiota composition,mucosal immune homeostasis,and barrier function to early life galactooligosaccharides intervention in suckling piglets[J].Journal of Agricultural and Food Chemistry,2019,67(2):578-588.

[19] 冯丹,张民扬,田时祎,等.日粮添加壳聚糖螯合锌对大肠杆菌攻毒断奶大鼠回肠形态结构及屏障功能的影响[J].南京农业大学学报,2021,44(3):541-547. FENG D,ZHANG M Y,TIAN S Y,et al.The effects of dietary supplementation with chitosan-chelated zinc on the ileal morphology and barrier function in weaned rats challenged with
Escherichia coli[J].Journal of Nanjing Agricultural University,2021,44(3):541-547.(in Chinese)
[20] WU T,ZHANG Y,LV Y,et al.Beneficial impact and molecular mechanism of
Bacillus coagulans on piglets’ intestine[J].International Journal of Molecular Sciences,2018,19(7):2084.
[21] YIN F Q,LAN R X,WU Z M,et al.
Yupingfeng polysaccharides enhances growth performance in
Qingyuan partridge chicken by up-regulating the mRNA expression of SGLT1,GLUT2 and GLUT5[J].Veterinary Medicine and Science,2019,5(3):451-461.

[22] MARKOVIĆ R,ŠEFER D,KRSTIĆ M,et al.Effect of different growth promoters on broiler performance and gut morphology[J].Archivos de Medicina Veterinaria,2009,41(2):163-169.
[23] KAMBOH A A,ZHU W Y.Individual and combined effects of genistein and hesperidin on immunity and intestinal morphometry in lipopolysacharide-challenged broiler chickens[J].Poultry Science,2014,93(9):2175-2183.

[24] MACDONALD T T,MONTELEONE G.Immunity,inflammation,and allergy in the gut[J].Science,2005,307(5717):1920-1925.

[25] CHEN S N,ZHAO H A,CHENG N,et al.Rape bee pollen alleviates dextran sulfate sodium (DSS)-induced colitis by neutralizing IL-1β and regulating the gut microbiota in mice[J].Food Research International,2019,122:241-251.
[26] VOLSTATOVA T,MARSIK P,RADA V,et al.Effect of apple extracts and selective polyphenols on the adhesion of potential probiotic strains of
Lactobacillus gasseri R and
Lactobacillus casei FMP[J].Journal of Functional Foods,2017,35:391-397.
[27] RICHTER J,BROUWER S,SCHRODER K,et al.Inflammasome activation and IL-1β signalling in group A
Streptococcus disease[J].Cellular Microbiology,2021,23(9):e13373.
[28] BERNARD K.The genus corynebacterium and other medically relevant coryneform-like bacteria[J].Journal of Clinical Microbiology,2012,50(10):3152-3158.

[29] BRAVO L.Polyphenols:chemistry,dietary sources,metabolism,and nutritional significance[J].Nutrition Reviews,1998,56(11):317-333.
[30] TAGURI T,TANAKA T,KOUNO I.Antibacterial spectrum of plant polyphenols and extracts depending upon hydroxyphenyl structure[J].Biological & Pharmaceutical Bulletin,2006,29(11):2226-2235.

[31] 马庆一,陈春涛,荆晓艳,等.橙皮甙等桔皮活性成分的提取和抑菌作用研究[J].食品科学,2004,25(12):112-115. MA Q Y,CHEN C T,JING X Y,et al.Studies on extraction of hesperidin and other active components from citrus peels and their antimicrobial effects[J].Food Science,2004,25(12):112-115.(in Chinese)
[32] VINOLO M A,RODRIGUES H G,NACHBAR R T,et al.Regulation of inflammation by short chain fatty acids[J].Nutrients,2011,3(10):858-876.

[33] MEI X R,ZHANG X Y,WANG Z G,et al.Insulin sensitivity-enhancing activity of phlorizin is associated with lipopolysaccharide decrease and gut microbiota changes in obese and type 2 diabetes (
db/db) mice[J].Journal of Agricultural and Food Chemistry,2016,64(40):7502-7511.

[34] CHEN D W,CHEN C M,QU H X,et al.Screening of
Lactobacillus strains that enhance SCFA uptake in intestinal epithelial cells[J].European Food Research and Technology,2021,247(5):1049-1060.

[35] TEDELIND S,WESTBERG F,KJERRULF M,et al.Anti-inflammatory properties of the short-chain fatty acids acetate and propionate:a study with relevance to inflammatory bowel disease[J].World Journal of Gastroenterology,2007,13(20):2826-2832.

[36] SELIM N M,ELGAZAR A A,ABDEL-HAMID N M,et al.Chrysophanol,physcion,hesperidin and curcumin modulate the gene expression of pro-inflammatory mediators induced by LPS in HepG2:in silico and molecular studies[J].Antioxidants,2019,8(9):371.
[37] GUHA M,MACKMAN N.LPS induction of gene expression in human monocytes[J].Cellular Signalling,2001,13(2):85-94.

[38] FITZGERALD K A,PALSSON-MCDERMOTT E M,BOWIE A G,et al.Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction[J].Nature,2001,413(6851):78-83.

[39] SHIRVANI H,MIRNEJAD R,SOLEIMANI M,et al.Swimming exercise improves gene expression of
PPAR-
γ and downregulates the overexpression of
TLR4,
MyD88,
IL-6,and
TNF-α after high-fat diet in rat skeletal muscle cells[J].Gene,2021,775:145441.
[40] HE C M,DENG J,HU X,et al.Vitamin A inhibits the action of LPS on the intestinal epithelial barrier function and tight junction proteins[J].Food & Function,2019,10(2):1235-1242.

[41] KUO W T,ZUO L,TURNER J.The tight junction protein ZO-1 regulates mitotic spindle orientation to enable efficient mucosal repair[J].Gastroenterology,2021,160(3,Supplement):S37.
[42] BILLINGS S D,WALSH S V,FISHER C,et al.Aberrant expression of tight junction-related proteins ZO-1,claudin-1 and occludin in synovial sarcoma:an immunohistochemical study with ultrastructural correlation[J].Modern Pathology,2004,17(2):141-149.

[43] POMOTHY J M,BARNA R F,PÁSZTI E A,et al.Beneficial effects of rosmarinic acid on IPEC-J2 cells exposed to the combination of deoxynivalenol and T-2 toxin[J].Mediators of Inflammation,2020,2020:8880651.