[1] CONRAD R.Quantification of methanogenic pathways using stable carbon isotopic signatures:a review and a proposal[J].Organic Geochemistry, 2005, 36(5):739-752.

[2] PACHAURI R K, ALLEN M R, BARROS V R, et al.Climate change 2014:synthesis report.Contribution of working groups Ⅰ, Ⅱ and Ⅲ to the fifth assessment report of the intergovernmental panel on climate change[M].Geneva:IPCC, 2014:151.
[3] Intergovernmental Panel on Climate Change.Climate change 2014:mitigation of climate change.Contribution of working group Ⅲ to the fifth assessment report of the intergovernmental panel on climate change[M].New York:Cambridge University Press, 2014.
[4] CHENG H.Future earth and sustainable developments[J].Innovation, 2020, 1(3):100055.
[5] JOHNSON K A, JOHNSON D E.Methane emissions from cattle[J].Journal of Animal Science, 1995, 73(8):2483-2492.

[6] 乌拉尔·沙尔赛开.世界人口展望:人口、资源与环境[J].生态经济, 2017, 33(9):2-5. SHAERSAIKAI W L E.World population outlook:population, resources and environment[J].Ecological Economy, 2017, 33(9):2-5.(in Chinese)
[7] 王之盛, 李胜利.反刍动物营养学[M].北京:中国农业出版社, 2016. WANG Z S, LI S L.Ruminant nutrition[M].Beijing:China Agriculture Press, 2016.(in Chinese)
[8] 刘建新.反刍动物营养生理[M].北京:中国农业出版社, 2019. LIU J X.Nutritional physiology of ruminants[M].Beijing:China Agriculture Press, 2019.(in Chinese)
[9] DUVAL S, KINDERMANN M.Use of nitrooxy organic molecules in feed for reducing methane emission in ruminants, and/or to improve ruminant performance:US 2014/0147529 A1[P].2014-05-29.
[10] HRISTOV A N, OH J, GIALLONGO F, et al.An inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production[J].Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(34):10663-10668.

[11] THIEL A, SCHOENMAKERS A C M, VERBAAN I A J, et al.3-NOP:mutagenicity and genotoxicity assessment[J].Food and Chemical Toxicology, 2019, 123:566-573.
[12] ZHANG X M, GRUNINGER R J, ALEMU A W, et al.3-Nitrooxypropanol supplementation had little effect on fiber degradation and microbial colonization of forage particles when evaluated using the
in situ ruminal incubation technique[J].Journal of Dairy Science, 2020, 103(10):8986-8997.

[13] BLACK J L, DAVISON T M, BOX I.Methane emissions from ruminants in Australia:mitigation potential and applicability of mitigation strategies[J].Animals, 2021, 11(4):951.
[14] ALEMU A W, PEKRUL L K D, SHRECK A L, et al.3-Nitrooxypropanol decreased enteric methane production from growing beef cattle in a commercial feedlot:implications for sustainable beef cattle production[J].Frontiers in Animal Science, 2021, 2:641590.
[15] G MARTINEZ-FEMANDEZ, L ABECIA, A ARCO, et al.Effects of ethyl-3-nitrooxy propionate and 3-nitrooxypropanol on ruminal fermentation, microbial abundance, and methane emissions in sheep[J].Journal of Dairy Science, 2014, 97(6):3790-3799.

[16] THIEL A, RVMBELI R, MAIR P, et al.3-NOP:ADME studies in rats and ruminating animals[J].Food and Chemical Toxicology, 2019, 125:528-539.
[17] ZHANG X M, SMITH M L, GRUNINGER R J, et al.Combined effects of 3-nitrooxypropanol and canola oil supplementation on methane emissions, rumen fermentation and biohydrogenation, and total tract digestibility in beef cattle[J].Journal of Animal Science, 2021, 99(4):1-10.
[18] RUDOLF K T.Energy metabolism of methanogenic bacteria pathways of energy conservation in methanogenic
Archaea[J].Biochimica et Biophysica Acta, 1990, 1018:256-259.
[19] DEPPENMEIER U.The unique biochemistry of methanogenesis[J].Progress in Nucleic Acid Research and Molecular Biology, 2002, 71:223-283.
[20] GUINDO C O, DAVOUST B, DRANCOURT M, et al.Diversity of methanogens in animals' gut[J].Microorganisms, 2020, 9(1):13.
[21] JONES W J, NAGLE D P, Jr, WHITMAN W B.Methanogens and the diversity of archaebacteria[J].Microbiological Reviews, 1987, 51(1):135-177.

[22] FERRY J G.Biochemistry of methanogenesis[J].Critical Reviews in Biochemistry and Molecular Biology, 1992, 27(6):473-503.

[23] 李煜珊, 李耀明, 欧阳志云.产甲烷微生物研究概况[J].环境科学, 2014, 35(5):2025-2030. LI Y S, LI Y M, OUYANG Z Y.A research overview of methanogens[J].Environmental Science, 2014, 35(5):2025-2030.(in Chinese)
[24] 郭嫣秋, 胡伟莲, 刘建新.瘤胃甲烷菌及甲烷生成的调控[J].微生物学报, 2005, 45(1):145-148. GUO Y Q, HU W L, LIU J X.Methanogens and manipulation of methane production in the rumen[J].Acta Microbiologica Sinica, 2005, 45(1):145-148.(in Chinese)
[25] BLAUT M.Metabolism of methanogens[J].Antonie van Leeuwenhoek, 1994, 66(1/2/3):187-208.
[26] DANIELS L.Chapter 3 Biochemistry of methanogenesis[M]//KATES M, KUSHNER D J, MATHESON A T.New Comprehensive Biochemistry:the Biochemistry of Archaea (Archaebacteria).New York:Elsevier, 1993:41-112.
[27] GARCIA J L, PATEL B K C, OLLIVIER B.Taxonomic, phylogenetic, and ecological diversity of methanogenic
Archaea[J].Anaerobe, 2000, 6(4):205-226.

[28] ROUVIōRE P E, WOLFE R S.Novel biochemistry of methanogenesis[J].Journal of Biological Chemistry, 1988, 263(17):7913-7916.

[29] CRAFT J L, HORNG Y C, RAGSDALE S W, et al.Nickel oxidation states of F(430) cofactor in methyl-coenzyme M reductase[J].Journal of the American Chemical Society, 2004, 126(13):4068-4069.

[30] SCHELLER S, GOENRICH M, THAUER R K, et al.Methyl-coenzyme M reductase from methanogenic Archaea:isotope effects on the formation and anaerobic oxidation of methane[J].Journal of the American Chemical Society, 2013, 135(40):14975-14984.

[31] GOUBEAUD M, SCHREINER G, THAUER R K.Purified methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the nickel(Ⅰ) oxidation state by titanium(Ⅲ) citrate[J].European Journal of Biochemistry, 1997, 243(1/2):110-114.
[32] ERMLER U.On the mechanism of methyl-coenzyme M reductase[J].Dalton Transactions, 2005, 21:3451-3458.
[33] WONGNATE T, SLIWA D, GINOVSKA B, et al.The radical mechanism of biological methane synthesis by methyl-coenzyme M reductase[J].Science, 2016, 352(6288):953-958.

[34] CHEN S L, BLOMBERG M R A, SIEGBAHN P E M.An investigation of possible competing mechanisms for Ni-containing methyl-coenzyme M reductase[J].Physical Chemistry Chemical Physics, 2014, 16(27):14029-14035.

[35] THAUER R K.The Wolfe cycle comes full circle[J].Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(38):15084-15085.

[36] DUIN E C, WAGNER T, SHIMA S, et al.Mode of action uncovered for the specific reduction of methane emissions from ruminants by the small molecule 3-nitrooxypropanol[J].Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(22):6172-6177.

[37] MELGAR A, LAGE C F A, NEDELKOV K, et al.Enteric methane emission, milk production, and composition of dairy cows fed 3-nitrooxypropanol[J].Journal of Dairy Science, 2021, 104(1):357-366.

[38] ROMERO-PEREZ A, OKINE E K, MCGINN S M, et al.The potential of 3-nitrooxypropanol to lower enteric methane emissions from beef cattle[J].Journal of Animal Science, 2014, 92(10):4682-4693.

[39] VYAS D, MCGINN S M, DUVAL S M, et al.Effects of sustained reduction of enteric methane emissions with dietary supplementation of 3-nitrooxypropanol on growth performance of growing and finishing beef cattle[J].Journal of Animal Science, 2016, 94(5):2024-2034.

[40] DIJKSTRA J, BANNINK A, FRANCE J, et al.Short communication:antimethanogenic effects of 3-nitrooxypropanol depend on supplementation dose, dietary fiber content, and cattle type[J].Journal of Dairy Science, 2018, 101(10):9041-9047.

[41] VYAS D, MCGINN S M, DUVAL S M, et al.Optimal dose of 3-nitrooxypropanol for decreasing enteric methane emissions from beef cattle fed high-forage and high-grain diets[J].Animal Production Science, 2016, 58(6):1049-1055.
[42] REYNOLDS C K, HUMPHRIES D J, KIRTON P, et al.Effects of 3-nitrooxypropanol on methane emission, digestion, and energy and nitrogen balance of lactating dairy cows[J].Journal of Dairy Science, 2014, 97(6):3777-3789.

[43] 杨卓, 马勇, 张力莉, 等.3-硝基酯-1-丙醇在反刍动物生产中的应用研究进展[J].动物营养学报, 2020, 32(11):5053-5058. YANG Z, MA Y, ZHANG L L, et al.Research progress on application of 3-nitrooxypropanol in ruminants production[J].Chinese Journal of Animal Nutrition, 2020, 32(11):5053-5058.(in Chinese)
[44] HAISAN J, SUN Y, GUAN L L, et al.The effects of feeding 3-nitrooxypropanol on methane emissions and productivity of Holstein cows in mid lactation[J].Journal of Dairy Science, 2014, 97(5):3110-3119.

[45] JAYANEGARA A, SARWONO K A, KONDO M, et al.Use of 3-nitrooxypropanol as feed additive for mitigating enteric methane emissions from ruminants:a meta-analysis[J].Italian Journal of Animal Science, 2018, 17(3):650-656.

[46] MELGAR A, WELTER K C, NEDELKOV K, et al.Dose-response effect of 3-nitrooxypropanol on enteric methane emissions in dairy cows[J].Journal of Dairy Science, 2020, 103(7):6145-6156.