[1] KAWSER HOSSAIN M, ABDAL DAYEM A, HAN J, et al.Molecular mechanisms of the anti-obesity and anti-diabetic properties of flavonoids[J].International Journal of Molecular Sciences, 2016, 17(4):569.
[2] WANG F, LIU J C, ZHOU R J, et al.Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression[J].Chemico-Biological Interactions, 2017, 275:171-177.
[3] JUNG U J, LEE M K, PARK Y B, et al.Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice[J].The International Journal of Biochemistry & Cell Biology, 2006, 38(7):1134-1145.

[4] AKIYAMA S, KATSUMATA S I, SUZUKI K, et al.Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes[J].Bioscience, Biotechnology, and Biochemistry, 2009, 73(12):2779-2782.

[5] SANDOVAL V, SANZ-LAMORA H, ARIAS G, et al.Metabolic impact of flavonoids consumption in obesity:from central to peripheral[J].Nutrients, 2020, 12(8):2393.
[6] RAHMAN N A, WAN ISHAK W R.Nutritional compositions and antioxidative capacity of the silk obtained from immature and mature corn[J].Journal of King Saud University-Science, 2014, 26(2):119-127.

[7] ZHAO L, WANG Y, LIU J, et al.Protective effects of genistein and puerarin against chronic alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms[J].Journal of Agricultural and Food Chemistry, 2016, 64(38):7291-7297.

[8] WANG Y, HUANG F H, ZHAO L, et al.Protective effect of total flavones from
Hippophae rhamnoides L. against visible light-induced retinal degeneration in pigmented rabbits[J].Journal of Agricultural and Food Chemistry, 2016, 64(1):161-170.

[9] 贺军与, 钟伟, 陈云琼, 等.大麦成熟籽粒中15种黄酮类化合物的含量差异分析[J].云南农业大学学报(自然科学), 2021, 36(6):931-936. HE J Y, ZHONG W, CHEN Y Q, et al.Analysis on the difference among the contents of 15 flavonoids compound in barley mature grains[J].Journal of Yunnan Agricultural University (Natural Science), 2021, 36(6):931-936.(in Chinese)
[10] ROZMER Z, PERJÉSI P.Naturally occurring chalcones and their biological activities[J].Phytochemistry Reviews, 2016, 15(1):87-120.

[11] 邓培华.苜蓿黄酮在畜牧生产中的应用效果[J].中国畜禽种业, 2020, 16(11):72-73. DENG P H.Application effect of alfalfa flavone in animal husbandry[J].The Chinese Livestock and Poultry Breeding, 2020, 16(11):72-73.(in Chinese)
[12] GOMES J V P, RIGOLON T C B, DA SILVEIRA SOUZA M S, et al.Antiobesity effects of anthocyanins on mitochondrial biogenesis, inflammation, and oxidative stress:a systematic review[J].Nutrition, 2019, 66:192-202.
[13] SONG H Z, SHEN X C, DENG R, et al.Dietary anthocyanin-rich extract of açai protects from diet-induced obesity, liver steatosis, and insulin resistance with modulation of gut microbiota in mice[J].Nutrition, 2021, 86:111176.
[14] SEMEN K O, WESELER A R, JANSSEN M J W, et al.Effects of monomeric and oligomeric flavanols on kidney function, inflammation and oxidative stress in runners:a randomized double-blind pilot study[J].Nutrients, 2020, 12(6):1634.
[15] COIA H, MA N, HOU Y Q, et al.Theaphenon E prevents fatty liver disease and increases CD4
+ T cell survival in mice fed a high-fat diet[J].Clinical Nutrition, 2021, 40(1):110-119.

[16] ZHANG X H, ZHANG Y Z, GAO W, et al.Naringin improves lipid metabolism in a tissue-engineered liver model of NAFLD and the underlying mechanisms[J].Life Sciences, 2021, 277:119487.
[17] RUPASINGHE H P V, SEKHON-LOODU S, MANTSO T, et al.Phytochemicals in regulating fatty acid β-oxidation:potential underlying mechanisms and their involvement in obesity and weight loss[J].Pharmacology & Therapeutics, 2016, 165:153-163.
[18] DUAN Y B, EDUARDO MELO SANTIAGO F, RODRIGUES DOS REIS A, et al.Genotypic variation of flavonols and antioxidant capacity in broccoli[J].Food Chemistry, 2021, 338:127997.
[19] LI H, PARK H M, JI H S, et al.Phenolic-enriched blueberry-leaf extract attenuates glucose homeostasis, pancreatic β-cell function, and insulin sensitivity in high-fat diet-induced diabetic mice[J].Nutrition Research, 2020, 73:83-96.
[20] LIN Y, SHI D F, SU B, et al.The effect of green tea supplementation on obesity:a systematic review and dose-response meta-analysis of randomized controlled trials[J].Phytotherapy Research, 2020, 34(10):2459-2470.

[21] AL-ISHAQ R K, ABOTALEB M, KUBATKA P, et al.Flavonoids and their anti-diabetic effects:cellular mechanisms and effects to improve blood sugar levels[J].Biomolecules, 2019, 9(9):430.
[22] ROCKWOOD S, MASON D, LORD R, et al.Genistein diet improves body weight, serum glucose and triglyceride levels in both male and female
ob/ob mice[J].Diabetes, Metabolic Syndrome and Obesity:Targets and Therapy, 2019, 12:2011-2021.
[23] SÁNCHEZ MACARRO M, MARTÍNEZ RODRÍGUEZ J P, BERNAL MORELL E, et al.Effect of a combination of citrus flavones and flavanones and olive polyphenols for the reduction of cardiovascular disease risk:an exploratory randomized, double-blind, placebo-controlled study in healthy subjects[J].Nutrients, 2020, 12(5):1475.
[24] BRODOWSKA K M.Natural flavonoids:classification, potential role, and application of flavonoid analogues[J].European Journal of Biological Research, 2017, 7(2):108-123.
[25] ZHOU Y J, XU N, ZHANG X C, et al.Chrysin improves glucose and lipid metabolism disorders by regulating the AMPK/PI3K/AKT signaling pathway in insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice[J].Journal of Agricultural Food Chemistry, 2021, 69(20):5618-5627.

[26] CARDOZO C M L, INADA A C, CARDOSO C A L, et al.Effect of supplementation with hydroethanolic extract of
Campomanesia xanthocarpa (Berg.) leaves and two isolated substances from the extract on metabolic parameters of mice fed a high-fat diet[J].Molecules, 2020, 25(11):2693.
[27] ZHU X B, LIU J K, CHEN S J, et al.Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity[J].BMC Neuroscience, 2019, 20(1):41.
[28] LIOU C J, LEE Y K, TING N C, et al.Protective effects of licochalcone a ameliorates obesity and non-alcoholic fatty liver disease via promotion of the Sirt-1/AMPK pathway in mice fed a high-fat diet[J].Cells, 2019, 8(5):447.
[29] PRASAD S, PHROMNOI K, YADAV V R, et al.Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer[J].Planta Medica, 2010, 76(11):1044-1063.

[30] LIU X X, LV Y, ZHENG M Y, et al.Polyphenols from blue honeysuckle (
Lonicera caerulea var.
edulis) berry inhibit lipid accumulation in adipocytes by suppressing lipogenesis[J].Journal of Ethnopharmacology, 2021, 279:114403.
[31] CHOI M, MUKHERJEE S, YUN J W.Anthocyanin oligomers stimulate browning in 3T3-L1 white adipocytes via activation of the β3-adrenergic receptor and ERK signaling pathway[J].Phytotherapy Research, 2021, 35(11):6281-6294.

[32] HERRERA-BALANDRANO D D, CHAI Z, HUTABARAT R P, et al.Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation:
in vitro and
in vivo studies[J].Redox Biology, 2021, 46:102100.
[33] LEE W, SORN S R, PARK Y, et al.Anthocyanin rich-black soybean testa improved visceral fat and plasma lipid profiles in overweight/obese Korean adults:a randomized controlled trial[J].Journal of Medicinal Food, 2016, 19(11):995-1003.

[34] HILES A M, FLOOD T R, LEE B J, et al.Dietary supplementation with New Zealand blackcurrant extract enhances fat oxidation during submaximal exercise in the heat[J].Journal of Science and Medicine in Sport, 2020, 23(10):908-912.

[35] SUGIURA C, ZHENG G D, LIU L T, et al.Catechins and caffeine promote lipid metabolism and heat production through the transformation of differentiated 3T3-L1 adipocytes from white to beige adipocytes[J].Journal of Food Science, 2020, 85(1):192-200.

[36] JIANG Y, DING S J, LI F, et al.Effects of (+)-catechin on the differentiation and lipid metabolism of 3T3-L1 adipocytes[J].Journal of Functional Foods, 2019, 62:103558.
[37] ZHANG Y Z, GU M X, WANG R R, et al.Dietary supplement of
Yunkang 10 green tea and treadmill exercise ameliorate high fat diet induced metabolic syndrome of C57BL/6J mice[J].Nutrition & Metabolism, 2020, 17(1):14.
[38] ZHANG S M, TAKANO J, MURAYAMA N, et al.Subacute ingestion of caffeine and oolong tea increases fat oxidation without affecting energy expenditure and sleep architecture:a randomized, placebo-controlled, double-blinded cross-over trial[J].Nutrients, 2020, 12(12):3671.
[39] ÁNGEL GARCÍA-MERINO J, MORENO-PÉREZ D, DE LUCAS B, et al.Chronic flavanol-rich cocoa powder supplementation reduces body fat mass in endurance athletes by modifying the follistatin/myostatin ratio and leptin levels[J].Food & Function, 2020, 11(4):3441-3450.

[40] KATANASAKA Y, MIYAZAKI Y, SUNAGAWA Y, et al.Kosen-cha, a polymerized catechin-rich green tea, as a potential functional beverage for the reduction of body weight and cardiovascular risk factors:a pilot study in obese patients[J].Biological & Pharmaceutical Bulletin, 2020, 43(4):675-681.

[41] DAYARATHNE L A, RANAWEERA S S, NATRAJ P, et al.Restoration of the adipogenic gene expression by naringenin and naringin in 3T3-L1 adipocytes[J].Journal of Veterinary Science, 2021, 22(4):e55.
[42] DING S M, QIU H M, HUANG J J, et al.Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy[J].Chemico-Biological Interactions, 2019, 307:116-124.
[43] PENG P, JIN J, ZOU G L, et al.Hesperidin prevents hyperglycemia in diabetic rats by activating the insulin receptor pathway[J].Experimental and Therapeutic Medicine, 2021, 21(1):53.
[44] MARTÍNEZ NOGUERA F J, ALCARAZ P E, CARLOS VIVAS J, et al.8 weeks of 2 S-hesperidin supplementation improves muscle mass and reduces fat in amateur competitive cyclists:randomized controlled trial[J].Food & Function, 2021, 12(9):3872-3882.

[45] YANG Z G, WEN X F, LI Y H, et al.Inhibitory effects of the constituents of
Hippophae rhamnoides on 3T3-L1 cell differentiation and nitric oxide production in RAW264.7 cells[J].Chemical & Pharmaceutical Bulletin, 2013, 61(3):279-285.

[46] KIM S C, KIM Y H, SON S W, et al.Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells[J].Biochemical and Biophysical Research Communications, 2015, 467(4):638-644.

[47] COÊLHO C F F, SOUZA I L S, CHAGAS V T, et al.Myricetin improves metabolic outcomes but not cognitive deficit associated to metabolic syndrome in male mice[J].Food & Function, 2021, 12(8):3586-3596.

[48] MADKHALI H A.Morin attenuates high-fat diet induced-obesity related vascular endothelial dysfunction in Wistar albino rats[J].Saudi Pharmaceutical Journal, 2020, 28(3):300-307.

[49] NIEMAN D C, SIMONSON A, SAKAGUCHI C A, et al.Acute ingestion of a mixed flavonoid and caffeine supplement increases energy expenditure and fat oxidation in adult women:a randomized, crossover clinical trial[J].Nutrients, 2019, 11(11):2665.
[50] NISHIMURA M, MURO T, KOBORI M, et al.Effect of daily ingestion of quercetin-rich onion powder for 12 weeks on visceral fat:a randomised, double-blind, placebo-controlled, parallel-group study[J].Nutrients, 2019, 12(1):91.
[51] GAUTAM J, KHEDGIKAR V, KUSHWAHA P, et al.Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss[J].British Journal of Nutrition, 2017, 117(5):645-661.

[52] PALACIOS-GONZÁLEZ B, VARGAS-CASTILLO A, VELÁZQUEZ-VILLEGAS L A, et al.Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice[J].The Journal of Nutritional Biochemistry, 2019, 68:59-68.
[53] LIU H H, ZHONG H J, LENG L, et al.Effects of soy isoflavone on hepatic steatosis in high fat-induced rats[J].Journal of Clinical Biochemistry and Nutrition, 2017, 61(2):85-90.

[54] AKHLAGHI M, ZARE M, NOURIPOUR F.Effect of soy and soy isoflavones on obesity-related anthropometric measures:a systematic review and meta-analysis of randomized controlled clinical trials[J].Advances in Nutrition, 2017, 8(5):705-717.

[55] CURTIS P J, SAMPSON M, POTTER J, et al.Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes:a 1-year, double-blind, randomized, controlled trial[J].Diabetes Care, 2012, 35(2):226-232.

[56] SUN W L, LIU P P, WANG T Q, et al.Baicalein reduces hepatic fat accumulation by activating AMPK in oleic acid-induced HepG2 cells and high-fat diet-induced non-insulin-resistant mice[J].Food & Function, 2020, 11(1):711-721.

[57] SUN J H, WANG Z D, CHEN L, et al.Hypolipidemic effects and preliminary mechanism of chrysanthemum flavonoids, its main components luteolin and luteoloside in hyperlipidemia rats[J].Antioxidants, 2021, 10(8):1309.
[58] SUN W L, YANG J W, DOU H Y, et al.Anti-inflammatory effect of luteolin is related to the changes in the gut microbiota and contributes to preventing the progression from simple steatosis to nonalcoholic steatohepatitis[J].Bioorganic Chemistry, 2021, 112:104966.
[59] SHIKISHIMA Y, TSUTSUMI R, KAWAKAMI A, et al.Sudachi peel extract powder including the polymethoxylated flavone sudachitin improves visceral fat content in individuals at risk for developing diabetes[J].Food Science & Nutrition, 2021, 9(8):4076-4084.

[60] SOLVERSON P M, RUMPLER W V, LEGER J L, et al.Blackberry feeding increases fat oxidation and improves insulin sensitivity in overweight and obese males[J].Nutrients, 2018, 10(8):1048.
[61] CHOI S, YU S, LEE J, et al.Effects of neohesperidin dihydrochalcone (NHDC) on oxidative phosphorylation, cytokine production, and lipid deposition[J].Foods, 2021, 10(6):1408.
[62] LEE H, LI H, KWEON M, et al.Isobavachalcone from
Angelica keiskei inhibits adipogenesis and prevents lipid accumulation[J].International Journal of Molecular Sciences, 2018, 19(6):1693.
[63] OHTA M, FUJINAMI A, OISHI K, et al.Ashitaba (
Angelica keiskei) exudate prevents increases in plasminogen activator inhibitor-1 induced by obesity in Tsumura Suzuki obese diabetic mice[J].Journal of Dietary Supplements, 2019, 16(3):331-344.

[64] LUO Z H, FU C F, LI T, et al.Hypoglycemic effects of licochalcone a on the streptozotocin-induced diabetic mice and its mechanism study[J].Journal of Agricultural and Food Chemistry, 2021, 69(8):2444-2456.

[65] OH H A, LEE H, PARK S Y, et al.Analysis of plasma metabolic profiling and evaluation of the effect of the intake of
Angelica keiskei using metabolomics and lipidomics[J].Journal of Ethnopharmacology, 2019, 243:112058.
[66] ARNER P, KULYTÉ A.MicroRNA regulatory networks in human adipose tissue and obesity[J].Nature Reviews Endocrinology, 2015, 11(5):276-288.

[67] BOMMER G T, MACDOUGALD O A.Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus[J].Cell Metabolism, 2011, 13(3):241-247.

[68] MOORE K J, RAYNER K J, SUÁREZ Y, et al.The role of microRNAs in cholesterol efflux and hepatic lipid metabolism[J].Annual Review of Nutrition, 2011, 31:49-63.
[69] GRACIA A, FERNÁNDEZ-QUINTELA A, MIRANDA J, et al.Are miRNA-103, miRNA-107 and miRNA-122 involved in the prevention of liver steatosis induced by resveratrol?[J].Nutrients, 2017, 9(4):360.
[70] SU D X, LIU H S, QI X Y, et al.Citrus peel flavonoids improve lipid metabolism by inhibiting
miR-33 and
miR-122 expression in HepG2 cells[J].Bioscience, Biotechnology, and Biochemistry, 2019, 83(9):1747-1755.

[71] SU D X, ZHANG R F, HOU F L, et al.Lychee pulp phenolics ameliorate hepatic lipid accumulation by reducing
miR-33 and
miR-122 expression in mice fed a high-fat diet[J].Food & Function, 2017, 8(2):808-815.

[72] GAN C C, NI T W, YU Y, et al.Flavonoid derivative (Fla-CN) inhibited adipocyte differentiation via activating AMPK and up-regulating microRNA-27 in 3T3-L1 cells[J].European Journal of Pharmacology, 2017, 797:45-52.
[73] PARRY S A, HODSON L.Influence of dietary macronutrients on liver fat accumulation and metabolism[J].Journal of Investigative Medicine, 2017, 65(8):1102-1115.

[74] 王密.槲皮素调节肉鸡脂质代谢的信号转导机制[D].博士学位论文.哈尔滨:东北农业大学, 2020. WANG M.Signal transduction mechanism of quercetin regulating lipid metabolism in broilers[D].Ph.D. Thesis.Harbin:Northeast Agricultural University, 2020.(in Chinese)
[75] LI Z P, XU J Y, ZHENG P Y, et al.Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway[J].International Journal of Clinical and Experimental Medicine, 2015, 8(10):17295-17307.
[76] LIU C M, MA J Q, SUN J M, et al.Flavonoid-rich extract of
Paulownia fortunei flowers attenuates diet-induced hyperlipidemia, hepatic steatosis and insulin resistance in obesity mice by AMPK pathway[J].Nutrients, 2017, 9(9):959.
[77] TUNG Y C, LI S M, HUANG Q R, et al.5-demethylnobiletin and 5-acetoxy-6, 7, 8, 3', 4'-pentamethoxyflavone suppress lipid accumulation by activating the LKB1-AMPK pathway in 3T3-L1 preadipocytes and high fat diet-fed C57BL/6 mice[J].Journal of Agricultural and Food Chemistry, 2016, 64(16):3196-3205.

[78] INAMDAR S, JOSHI A, MALIK S, et al.Vitexin alleviates non-alcoholic fatty liver disease by activating AMPK in high fat diet fed mice[J].Biochemical and Biophysical Research Communications, 2019, 519(1):106-112.

[79] SONG H Z, LAI J, TANG Q, et al.Mulberry ethanol extract attenuates hepatic steatosis and insulin resistance in high-fat diet-fed mice[J].Nutrition Research, 2016, 36(7):710-718.

[80] ZHANG Y N, PROENCA R, MAFFEI M, et al.Positional cloning of the mouse
obese gene and its human homologue[J].Nature, 1994, 372(6505):425-432.

[81] PAULUS A, VAN MARKEN LICHTENBELT W, MOTTAGHY F M, et al.Brown adipose tissue and lipid metabolism imaging[J].Methods, 2017, 130:105-113.
[82] WU J, BOSTRÖM P, SPARKS L M, et al.Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human[J].Cell, 2012, 150(2):366-376.

[83] STANFORD K I, MIDDELBEEK R J W, TOWNSEND K L, et al.Brown adipose tissue regulates glucose homeostasis and insulin sensitivity[J].The Journal of Clinical Investigation, 2013, 123(1):215-223.

[84] BOSTRÖM P, WU J, JEDRYCHOWSKI M P, et al.A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J].Nature, 2012, 481(7382):463-468.

[85] LIU J W, ZHAO Y Y, HUANG C, et al.Prenylated flavonoid-standardized extract from seeds of
Psoralea corylifolia L. activated fat browning in high-fat diet-induced obese mice[J].Phytotherapy Research, 2019, 33(7):1851-1864.

[86] KOZAK L P, ANUNCIADO-KOZA R.UCP1:its involvement and utility in obesity[J].International Journal of Obesity, 2008, 32(Suppl 7):S32-S38.
[87] LEE S G, PARKS J S, KANG H W.Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes[J].Journal of Nutritional Biochemistry, 2017, 42:62-71.
[88] ARIAS N, PICÓ C, TERESA MACARULLA M, et al.A combination of resveratrol and quercetin induces browning in white adipose tissue of rats fed an obesogenic diet[J].Obesity, 2017, 25(1):111-121.

[89] LI X L.SIRT1 and energy metabolism[J].Acta Biochimica et Biophysica Sinica, 2013, 45(1):51-60.

[90] HOU X Y, XU S Q, MAITLAND-TOOLAN K A, et al.SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase[J].The Journal of Biological Chemistry, 2008, 283(29):20015-20026.

[91] SALMINEN A, HYTTINEN J M, KAARNIRANTA K.AMP-activated protein kinase inhibits NF-κB signaling and inflammation:impact on healthspan and lifespan[J].Journal of Molecular Medicine, 2011, 89(7):667-676.

[92] SUN Y S, QU W.Dietary apigenin promotes lipid catabolism, thermogenesis, and browning in adipose tissues of HFD-fed mice[J].Food and Chemical Toxicology, 2019, 133:110780.
[93] FERNANDEZ-MARCOS P J, AUWERX J.Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis[J].The American Journal of Clinical Nutition, 2011, 93(4):884S-890S.
[94] SUWA M, NAKANO H, KUMAGAI S.Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles[J].Journal of Applied Physiology, 2003, 95(3):960-968.

[95] ZHANG X, ZHANG Q X, WANG X, et al.Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism[J].International Journal of Obesity, 2016, 40(12):1841-1849.

[96] CHOI J H, YUN J W.Chrysin induces brown fat-like phenotype and enhances lipid metabolism in 3T3-L1 adipocytes[J].Nutrition, 2016, 32(9):1002-1010.

[97] CHOI K M, LEE Y S, SIN D M, et al.Sulforaphane inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest[J].Obesity, 2012, 20(7):1365-1371.

[98] TANG Q Q, OTTO T C, LANE M D.Mitotic clonal expansion:a synchronous process required for adipogenesis[J].Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(1):44-49.

[99] KIM C Y, LE T T, CHEN C, et al.Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion[J].Journal of Nutritional Biochemistry, 2011, 22(10):910-920.

[100] KIM A R, YOON B K, PARK H, et al.Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes[J].BMB Reports, 2016, 49(2):111-115.

[101] SINGH J, KAKKAR P.Oroxylin A, a constituent of
Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells[J].Phytomedicine, 2014, 21(12):1733-1741.

[102] CHOI J W, LEE C W, LEE J, et al.7, 8-dihydroxyflavone inhibits adipocyte differentiation via antioxidant activity and induces apoptosis in 3T3-L1 preadipocyte cells[J].Life Sciences, 2016, 144:103-112.
[103] TANG Q Q, OTTO T C, LANE M D.CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis[J].Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(3):850-855.

[104] KIM C Y, BORDENAVE N, FERRUZZI M G, et al.Modification of curcumin with polyethylene glycol enhances the delivery of curcumin in preadipocytes and its antiadipogenic property[J].Journal of Agricultural and Food Chemistry, 2011, 59(3):1012-1019.

[105] KIM M A, KANG K, LEE H J, et al.Apigenin isolated from
Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion[J].Life Sciences, 2014, 101(1/2):64-72.
[106] WU R F, YAO Y X, JIANG Q, et al.Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m
6A-YTHDF2-dependent manner[J].International Journal of Obesity, 2018, 42(7):1378-1388.

[107] HUNTER T, PINES J.Cyclins and cancer.Ⅱ:cyclin D and CDK inhibitors come of age[J].Cell, 1994, 79(4):573-582.

[108] LEE M H, KIM H M, CHUNG H C, et al.Licorice extract suppresses adipogenesis through regulation of mitotic clonal expansion and adenosine monophosphate-activated protein kinase in 3T3-L1 cells[J].Journal of Food Biochemistry, 2020, 44(12):e13528.
[109] VAN VEEN J E, KAMMEL L G, BUNDA P C, et al.Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure[J].Nature Metabolism, 2020, 2(4):351-363.

[110] BADSHAH H, ULLAH I, KIM S E, et al.Anthocyanins attenuate body weight gain via modulating neuropeptide Y and GABAB1 receptor in rats hypothalamus[J].Neuropeptides, 2013, 47(5):347-353.

[