REVIEW

Structure of Adiponectin and Their Receptors and Action Mechanisms in Lipid Metabolism

  • ZHENG Yan ,
  • CAO Zhongzan ,
  • QIU Yunqiao ,
  • LUAN Xinhong
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  • College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China

Received date: 2021-11-27

  Online published: 2022-06-14

Abstract

Adiponectin (AdipoQ), an endogenous cytokine mainly secreted by adipose tissue, plays an important role in regulating lipid metabolism. AdipoQ binds first to its receptors (AdipoRl and AdipoR2) located at the C-terminus outside the membrane and then to signal adaptor proteins N-terminally through AdipoQ receptors, thereby activating downstream adenylate activated protein kinase (AMPK) to bind to peroxisome proliferators activate receptor alpha (PPAR-α) and other multiple signaling pathways, which promote fatty acid oxidation and inhibit lipid synthesis, thereby regulating lipid metabolism. In this review, we summarize the structure of AdipoQ and its receptors, the signaling adaptor proteins and the regulatory mechanisms of AdipoQ on lipid metabolism in animals.

Cite this article

ZHENG Yan , CAO Zhongzan , QIU Yunqiao , LUAN Xinhong . Structure of Adiponectin and Their Receptors and Action Mechanisms in Lipid Metabolism[J]. Chinese Journal of Animal Nutrition, 2022 , 34(6) : 3503 -3510 . DOI: 10.3969/j.issn.1006-267x.2022.06.012

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