Effects of Hyodeoxycholic Acid on Growth Performance, Energy Metabolism and Fat Digestion and Absorption of Mice

SONG Min; MA Xianyong; ZHANG Fenglin; WANG Chaopu; SU Han; JIANG Qingyan; WANG Songbo

doi:10.3969/j.issn.1006-267x.2022.06.057

Chinese Journal of Animal Nutrition >

2022 , Vol. 34 >Issue 6: 3983 - 3990

DOI: https://doi.org/10.3969/j.issn.1006-267x.2022.06.057

RESEARCHPAPER

Effects of Hyodeoxycholic Acid on Growth Performance, Energy Metabolism and Fat Digestion and Absorption of Mice

SONG Min ,
MA Xianyong ,
ZHANG Fenglin ,
WANG Chaopu ,
SU Han ,
JIANG Qingyan ,
WANG Songbo

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1. Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, State Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
2. College of Animal Science, South China Agricultural University, Guangzhou 510642, China;
3. Maoming Branch, Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, Maoming 525000, China;
4. College of Life Science and Engineering, Foshan University of Science and Technology, Foshan 528225, China

Received date: 2021-11-04

Online published: 2022-06-14

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Abstract

This experiment was conducted to investigate the effects of dietary hyodeoxycholic acid (HDCA) on growth, energy metabolism and fat digestion and absorption of mice. Twenty 3-week-old C57BL male mice were divided into control group and HDCA group, and were fed a basal diet and the basal diet supplemented with 1.5% HDCA, respectively. The experiment lasted for 10 weeks. The results showed that compared with the control group:1) HDCA had no significant effects on feed intake and final body weight of mice (P>0.05), but significantly decreased body weight gain of mice (P<0.05). In addition, HDCA significantly reduced the subcutaneous adipose tissue content of mice (P<0.05). 2) HDCA increased thermogenesis of brown adipose tissue (BAT) at 25 and 4℃ (P<0.05), and increased the basal metabolism in both day and night, suggesting that HDCA increased energy metabolism of mice. 3) HDCA extremely significantly reduced the apparent digestibility of crude fat of mice (P<0.01), thereby significantly increasing the crude fat content and fecal energy of mice (P<0.01). 4) HDCA tended to decrease the mRNA expression levels of pancreatic lipase-related genes bile salt-stimulating lipase (BSSL), pancreatic phospholipase A2 (PLA2), pancreatic triglyceride lipase (PTL), pancreatic lipase-related protein 1 (PLRP1) and pancreatic lipase-related protein 2 (PLRP2) of mice (0.05 ≤ P<0.10). In conclusion, dietary supplementation of 1.5% HDCA can improve the energy metabolism of mice, and reduce the digestion and absorption of fat of mice, thereby reducing the subcutaneous adipose tissue content and body weight gain of mice.

Key words： hyodeoxycholic acid; mice; growth performance; energy metabolism; fat; digestion and absorption

Cite this article

SONG Min , MA Xianyong , ZHANG Fenglin , WANG Chaopu , SU Han , JIANG Qingyan , WANG Songbo . Effects of Hyodeoxycholic Acid on Growth Performance, Energy Metabolism and Fat Digestion and Absorption of Mice[J]. Chinese Journal of Animal Nutrition, 2022 , 34(6) : 3983 -3990 . DOI: 10.3969/j.issn.1006-267x.2022.06.057

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