[1] KAMANNA V S,GANJI S H,KASHYAP M L.Recent advances in niacin and lipid metabolism[J].Current Opinion in Lipidology,2013,24(3):239-245.
[2] 刘世龙.烟酸对断奶仔猪肠道健康的影响[D].硕士学位论文.佛山:佛山科学技术学院,2020. LIU S L.Effects of niacin on intestinal health in weaned piglets[D].Master's Thesis.Foshan:Foshan University,2020.(in Chinese)
[3] KIM H S,XIAO C Y,WANG R H,et al.Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis[J].Cell Metabolism,2010,12(3):224-236.
[4] DING H Y,LI Y,LIU L H,et al.Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins[J].Journal of Animal Science,2021,99(10):skab250.
[5] SECK M,LINTON J A V,ALLEN M S,et al.Apparent ruminal synthesis of B vitamins in lactating dairy cows fed diets with different forage-to-concentrate ratios[J].Journal of Dairy Science,2017,100(3):1914-1922.
[6] 王灿宇,傅传鞭,瞿明仁,等.烟酸对夏南牛生长性能,养分消化率及血液生化指标的影响[J].江西农业大学学报,2014,36(6):1332-1336. WANG C Y,FU C B,QU M R,et al.Effect of niacin on growth performance,nutrient digestibility and blood biochemical index of
Xia Nan cattle[J].Acta Agriculturae Universitatis Jiangxiensis,2014,36(6):1332-1336.(in Chinese)
[7] 曾一鸣.日粮中不同烟酸水平对肉仔鸡生长性能和胫骨短促病发生率的影响[J].湖南畜牧兽医,2005(4):9-10. ZENG Y M.Effects of different dietary niacin levels on growth performance and incidence of short tibia disease in broilers[J].Hunan Journal of Animal Science & Veterinary Medicine,2005(4):9-10.(in Chinese)
[8] CHEN G X,HUANG B X,FU S P,et al.G protein-coupled receptor 109A and host microbiota modulate intestinal epithelial integrity during sepsis[J].Frontiers in Immunology,2018,9:2079.
[9] SINGH N,GURAV A,SIVAPRAKASAM S,et al.Activation of GPR109A,receptor for niacin and the commensal metabolite butyrate,suppresses colonic inflammation and carcinogenesis[J].Immunity,2014,40(1):128-139.
[10] SALEM H A,WADIE W L.Effect of niacin on inflammation and angiogenesis in a murine model of ulcerative colitis[J].Scientific Reports,2017,7(1):7139.
[11] GUO W J,LI W,SU Y C,et al.GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy[J].International Journal of Biological Sciences,2021,17(15):4271-4284.
[12] KARUNARATNE T B,OKEREKE C,SEAMON M,et al.Niacin and butyrate:nutraceuticals targeting dysbiosis and intestinal permeability in Parkinson's disease[J].Nutrients,2020,13(1):28.
[13] GIRI B,BELANGER K,SEAMON M,et al.Niacin ameliorates neuro-inflammation in Parkinson's disease via GPR109A[J].International Journal of Molecular Sciences,2019,20(18):4559.
[14] LIU S L,ZHU X P,QIU Y Q,et al.Effect of niacin on growth performance,intestinal morphology,mucosal immunity and microbiota composition in weaned piglets[J].Animals,2021,11(8):2186.
[15] SI Y H,ZHANG Y,ZHAO J L,et al.Niacin inhibits vascular inflammation via downregulating nuclear transcription factor-κB signaling pathway[J].Mediators of Inflammation,2014,2014:263786.
[16] DIGBY J E,MCNEILL E,DYAR O J,et al.Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine,RANTES,and MCP-1 and upregulation of adiponectin[J].Atherosclerosis,2010,209(1):89-95.
[17] GAMBHIR D,ANANTH S,VEERANAN-KARMEGAM R,et al.GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy[J].Investigative Ophthalmology & Visual Science,2012,53(4):2208-2217.
[18] DIGBY J E,MARTINEZ F,JEFFERSON A,et al.Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2012,32(3):669-676.
[19] FENG L,LI S Q,JIANG W D,et al.Deficiency of dietary niacin impaired intestinal mucosal immune function via regulating intestinal NF-κB,Nrf2 and MLCK signaling pathways in young grass carp (
Ctenopharyngodon idella)[J].Fish & Shellfish Immunology,2016,49:177-193.
[20] 段晨磊,王宝维,葛文华,等.烟酸对五龙鹅抗氧化性能和免疫性能的影响[J].中国畜牧杂志,2016,52(1):32-37. DUAN C L,WANG B W,GE W H,et al.Effects of different dietary level of nicotinic acid on anti-oxidation and immunity of
Wulong geese[J].Chinese Journal of Animal Science,2016,52(1):32-37.(in Chinese)
[21] 蒋亚军.烟酸、核黄素对奶牛生产性能、抗氧化能力和免疫力的影响[D].硕士学位论文.石河子:石河子大学,2011. JIANG Y J.Effects of nicotinic acid,riboflavin on performance,antioxidant capacitiy and immunity of dairy cows[D].Master's Thesis.Shihezi:Shihezi University,2011.(in Chinese)
[22] ARMAGAN G,SEVGILI E,GVRKAN F T,et al.Regulation of the Nrf2 pathway by glycogen synthase kinase-3β in MPP
+-induced cell damage[J].Molecules,2019,24(7):1377.
[23] YANG Q,ZHAO Z Z,XIE J,et al.Senkyunolide Ⅰ attenuates hepatic ischemia/reperfusion injury in mice via anti-oxidative,anti-inflammatory and anti-apoptotic pathways[J].International Immunopharmacology,2021,97:107717.
[24] WU N C,WANG J J.Niacin pretreatment attenuates lung ischemia and reperfusion-induced pulmonary barrier function impairment by reducing oxidative stress and activating SIRT1 in an isolated-perfused rat lung model[J].Transplantation Proceedings,2018,50(9):2834-2838.
[25] HU D,ZHANG L,JIANG R,et al.Nicotinic acid against acetaminophen-induced hepatotoxicity via Sirt1/Nrf2 antioxidative pathway in mice[J].Journal of Nutritional Science and Vitaminology,2021,67(3):145-152.
[26] PEREIRA L C,DE PAULA E S,PAZIN M,et al.Niacin prevents mitochondrial oxidative stress caused by sub-chronic exposure to methylmercury[J].Drug and Chemical Toxicology,2020,43(1):64-70.
[27] CHEN T H,WANG J J.Niacin pretreatment attenuates ischemia and reperfusion of pancreas-induced acute pancreatitis and remote lung injury through suppressing oxidative stress and inflammation and activation of SIRT1[J].Transplantation Proceedings,2018,50(9):2860-2863.
[28] MONTSERRAT-DE LA PAZ S,NARANJO M C,LOPEZ S,et al.Niacin and its metabolites as master regulators of macrophage activation[J].The Journal of Nutritional Biochemistry,2017,39:40-47.
[29] GOLDBERG A C.Clinical trial experience with extended-release niacin (Niaspan):dose-escalation study[J].The American Journal of Cardiology,1998,82(12 Suppl.1):35U-38U.
[30] KASHYAP M L,MCGOVERN M E,BERRA K,et al.Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia[J].The American Journal of Cardiology,2002,89(6):672-678.
[31] XIANG D,ZHANG Q,WANG Y T.Effectiveness of niacin supplementation for patients with type 2 diabetes:a Meta-analysis of randomized controlled trials[J].Medicine,2020,99(29):e21235.
[32] GALESCU O A,CROCKER M K,ALTSCHUL A M,et al.A pilot study of the effects of niacin administration on free fatty acid and growth hormone concentrations in children with obesity[J].Pediatric Obesity,2018,13(1):30-37.
[33] 杨玲.棕榈酸致BRL 3A细胞脂肪变性的机制及烟酸的保护作用[D].硕士学位论文.扬州:扬州大学,2020. YANG L.Mechanism of steatosis induced by palmitic acid in BRL 3A cells and the protective effect of niacin[D].Master's Thesis.Yangzhou:Yangzhou University,2020.(in Chinese)
[34] WANG J X,CAO Y,FU S P,et al.Niacin inhibits the synthesis of milk fat in BMECs through the GPR109A-mediated downstream signalling pathway[J].Life Sciences,2020,260:118415.
[35] YE L Y,CAO Z,LAI X R,et al.Niacin ameliorates hepatic steatosis by inhibiting
de novo lipogenesis via a GPR109A-mediated PKC-ERK1/2-AMPK signaling pathway in C57BL/6 mice fed a high-fat diet[J].The Journal of Nutrition,2020,150(4):672-684.
[36] ZIMMER M,BISTA P,BENSON E L,et al.CAT-2003:a novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis,plasma lipids,and atherosclerosis in apolipoprotein E
*3-Leiden mice[J].Hepatology Communications,2017,1(4):311-325.
[37] TUNARU S,KERO J,SCHAUB A,et al.PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect[J].Nature Medicine,2003,9(3):352-355.
[38] CARLSON L A.Studies on the effect of nicotinic acid on catecholamine stimulated lipolysis in adipose tissue
in vitro[J].Acta Medica Scandinavica,1963,173:719-722.
[39] HERNANDEZ C,MOLUSKY M,LI Y Q,et al.Regulation of hepatic ApoC3 expression by PGC-1β mediates hypolipidemic effect of nicotinic acid[J].Cell Metabolism,2010,12(4):411-419.
[40] CHOI S,YOON H,OH K S,et al.Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues:implications for unwanted effects of nicotinic acid treatment[J].Metabolism-Clinical and Experimental,2011,60(1):134-144.
[41] LIU L,LI C Y,FU C Y,et al.Dietary niacin supplementation suppressed hepatic lipid accumulation in rabbits[J].Asian-Australasian Journal of Animal Sciences,2016,29(12):1748-1755.
[42] KOPP C,HOSSEINI A,SINGH S P,et al.Nicotinic acid increases adiponectin secretion from differentiated bovine preadipocytes through G-protein coupled receptor signaling[J].International Journal of Molecular Sciences,2014,15(11):21401-21418.
[43] FUJIMORI K,AMANO F.Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression[J].Prostaglandins & Other Lipid Mediators,2011,94(3/4):96-103.
[44] JOO S T,KIM G D,HWANG Y H,et al.Control of fresh meat quality through manipulation of muscle fiber characteristics[J].Meat Science,2013,95(4):828-836.
[45] 王勇峰,丰永红,万红兵,等.新疆褐牛不同部位牛肉肌纤维类型及品质差异研究[J].食品工业科技,2018,39(6):19-24,37. WANG Y F,FENG Y H,WAN H B,et al.Study on the difference of muscle fiber types and quality in different parts of
Xinjiang brown cattle[J].Science and Technology of Food Industry,2018,39(6):19-24,37.(in Chinese)
[46] 王丽莎.肌纤维类型组成对猪肉持水力的影响[D].硕士学位论文.北京:中国农业科学院,2020. WANG L S.Effect of muscle fiber type composition on water-holding capacity of pork[D].Master's Thesis.Beijing:Chinese Academy of Agricultural Sciences,2020.(in Chinese)
[47] KHAN M,RINGSEIS R,MOOREN F C,et al.Niacin supplementation increases the number of oxidative type Ⅰ fibers in skeletal muscle of growing pigs[J].BMC Veterinary Research,2013,9:177.
[48] KHAN M,COUTURIER A,KUBENS J F,et al.Niacin supplementation induces type Ⅱ to type Ⅰ muscle fiber transition in skeletal muscle of sheep[J].Acta Veterinaria Scandinavica,2013,55(1):85.
[49] HOA V B,SEONG P N,CHO S H,et al.Quality characteristics and flavor compounds of pork meat as a function of carcass quality grade[J].Asian-Australasian Journal of Animal Sciences,2019,32(9):1448-1457.
[50] LI G X,ZHAO Y L,LI Y F,et al.Weighted gene coexpression network analysis identifies specific transcriptional modules and hub genes related to intramuscular fat traits in chicken breast muscle[J].Journal of Cellular Biochemistry,2019,120(8):13625-13639.
[51] WANG Y,HUI X H,WANG H E,et al.Association of
H-FABP gene polymorphisms with intramuscular fat content in three-yellow chickens and Hetian-black chickens[J].Journal of Animal Science and Biotechnology,2016,7:9.
[52] LUO Y H,ZHANG X,ZHU Z P,et al.Surplus dietary isoleucine intake enhanced monounsaturated fatty acid synthesis and fat accumulation in skeletal muscle of finishing pigs[J].Journal of Animal Science and Biotechnology,2018,9:88.
[53] ZHANG B B,HAO J Z,YIN H J,et al.Effects of dietary nicotinic acid supplementation on meat quality,carcass characteristics,lipid metabolism,and tibia parameters of
Wulong geese[J].Poultry Science,2021,100(11):101430.
[54] YANG Z Q,BAO L B,ZHAO X H,et al.Nicotinic acid supplementation in diet favored intramuscular fat deposition and lipid metabolism in finishing steers[J].Experimental Biology and Medicine,2016,241(11):1195-1201.
[55] KRÖMKER V,LEIMBACH S.Mastitis treatment-reduction in antibiotic usage in dairy cows[J].Reproduction in Domestic Animals,2017,52(Suppl.3):21-29.
[56] LI P,LIU Q P,ZHANG T,et al.Protective effects of lixisenatide against lipopolysaccharide-induced inflammation response in MAC-T bovine mammary epithelial cells:a therapeutic implication in mastitis[J].Chemical Research in Toxicology,2020,33(4):982-987.
[57] 李洪洋,南雪梅,孙鹏.褪黑素对脂多糖诱导的奶牛乳腺上皮细胞炎症反应的缓解作用[J].动物营养学报,2021,33(8):4637-4644. LI H Y,NAN X M,SUN P.Mitigative effects of melatonin on lipopolysaccharide-induced inflammation in bovine mammary epithelial cells[J].Chinese Journal of Animal Nutrition,2021,33(8):4637-4644.(in Chinese)
[58] CHENG L P,REN Y J,LIN D B,et al.The anti-inflammatory properties of
Citrus wilsonii Tanaka extract in LPS-induced RAW 264.7 and primary mouse bone marrow-derived dendritic cells[J].Molecules,2017,22(7):1213.
[59] GONG Q,LI Y W,MA H,et al.Peiminine protects against lipopolysaccharide-induced mastitis by inhibiting the AKT/NF-κB,ERK1/2 and p38 signaling pathways[J].International Journal of Molecular Sciences,2018,19(9):2637.
[60] KAYANO M,ITOH M,KUSABA N,et al.Associations of the first occurrence of pathogen-specific clinical mastitis with milk yield and milk composition in dairy cows[J].The Journal of Dairy Research,2018,85(3):309-316.
[61] GUO W J,LIU J X,LI W,et al.Niacin alleviates dairy cow mastitis by regulating the GPR109A/AMPK/NRF2 signaling pathway[J].International Journal of Molecular Sciences,2020,21(9):3321.
[62] 巩倩.烟酸对奶牛乳腺炎的治疗作用[D].硕士学位论文.长春:吉林大学,2020. GONG Q.The therapeutic effect of niacin on mastitis in dairy cows[D].Master's Thesis.Changchun:Jilin University,2020.(in Chinese)
[63] KIRKLAND J B,MEYER-FICCA M L.Chapter three-niacin[M]//ESKIN N A M.Advances in food and nutrition research:new research and developments of water-soluble vitamins.San Diego:Academic Press,2018:83-149.
[64] VAN DE VEN R A H,SANTOS D,HAIGIS M C.Mitochondrial sirtuins and molecular mechanisms of aging[J].Trends in Molecular Medicine,2017,23(4):320-331.
[65] PETERS K M,ZHANG R,PARK C,et al.Vitamin D intervention does not improve vascular regeneration in diet-induced obese male mice with peripheral ischemia[J].The Journal of Nutritional Biochemistry,2019,70:65-74.
[66] 王雪莹.烟酸对牦牛热应激期生长性能、营养物质表观消化率和脂质代谢的影响[D].硕士学位论文.雅安:四川农业大学,2019. WANG X Y.Effects of niacin on growth performance,apparent digestibility of nutrients and lipid metabolism in yak under heat-stress[D].Master's Thesis.Ya'an:Sichuan Agricultural University,2019.(in Chinese)
[67] JIANG R R,ZHAO G P,CHEN J L,et al.Effect of dietary supplemental nicotinic acid on growth performance,carcass characteristics and meat quality in three genotypes of chicken[J].Journal of Animal Physiology and Animal Nutrition,2011,95(2):137-145.
[68] 杨艳,欧阳克蕙,甘兴华,等.不同精粗比日粮中添加烟酸对牛瘤胃体外发酵功能的影响[J].江西农业学报,2021,33(5):76-82. YANG Y,OUYANG K H,GAN X H,et al.Effect of adding nicotinic acid to diets with different concentrate-forage ratios on
in vitro rumen fermentation function[J].Acta Agriculturae Jiangxi,2021,33(5):76-82.(in Chinese)
[69] PHILLIPS C.The welfare risks and impacts of heat stress on sheep shipped from Australia to the Middle East[J].The Veterinary Journal,2016,218:78-85.
[70] 刘政,王静,曹平,等.不同水平的烟酸对AA肉仔鸡血液生化指标及抗氧化性能的影响[J].畜牧与兽医,2016,48(11):95-97. LIU Z,WANG J,CAO P,et al.Effects of different levels of nicotinic acid on blood biochemical indices and antioxidant properties of AA broilers[J].Animal Husbandry & Veterinary Medicine,2016,48(11):95-97.(in Chinese)
[71] 刘晨龙,王宝维,葛文华,等.饲粮维生素B
5添加水平对产蛋期种鹅繁殖性能、蛋品质及血清生化和抗氧化指标的影响[J].动物营养学报,2021,33(5):2957-2963. LIU C L,WANG B W,GE W H,et al.Effects of dietary vitamin B
5 supplemental level on reproductive performance,egg quality and serum biochemical and antioxidant indices of breeding geese during laying period[J].Chinese Journal of Animal Nutrition,2021,33(5):2957-2963.(in Chinese)
[72] ADEBOWALE T,OSO A,LIU H N,et al.Effect of dietary niacin supplementation on growth performance,nutrient digestibility,hematology,and lipoprotein concentrations of young turkeys,
Meleagris gallopavo[J].The Journal of Poultry Science,2019,56(2):112-119.
[73] 王静,高爱琴,王乃凤.不同日粮烟酸水平对罗斯308肉仔鸡生产性能及肉质性状的影响[J].畜牧与兽医,2013,45(12):50-53. WANG J,GAO A Q,WANG N F.Effects of different dietary nicotinic acid levels on performance and meat quality traits of Ross 308 broilers[J].Animal Husbandry & Veterinary Medicine,2013,45(12):50-53.(in Chinese)
[74] ALMUBARAK A M,KIM E,YU I J,et al.Supplementation with niacin during
in vitro maturation improves the quality of porcine embryos[J].Theriogenology,2021,169:36-46.
[75] POLLARD C L,GIBB Z,HAWDON A,et al.Supplementing media with NAD
+ precursors enhances the
in vitro maturation of porcine oocytes[J].The Journal of Reproduction and Development,2021,67(5):319-326.
[76] FENG J S,WANG L,CHEN Y B,et al.Effects of niacin on intestinal immunity,microbial community and intestinal barrier in weaned piglets during starvation[J].International Immunopharmacology,2021,95:107584.
[77] REAL D E,NELSSEN J L,UNRUH J A,et al.Effects of increasing dietary niacin on growth performance and meat quality in finishing pigs reared in two different environments[J].Journal of Animal Science,2002,80(12):3203-3210.
[78] GAOWA N,ZHANG X M,LI H X,et al.Effects of rumen-protected niacin on dry matter intake,milk production,apparent total tract digestibility,and faecal bacterial community in multiparous Holstein dairy cow during the postpartum period[J].Animals,2021,11(3):617.
[79] ARAGONA K M,RICE E M,ENGSTROM M,et al.Supplementation of nicotinic acid to prepartum Holstein cows increases colostral immunoglobulin G,excretion of urinary purine derivatives,and feed efficiency in calves[J].Journal of Dairy Science,2020,103(3):2287-2302.
[80] ARAGONA K M,CHAPMAN C E,PEREIRA A B D,et al.Prepartum supplementation of nicotinic acid:effects on health of the dam,colostrum quality,and acquisition of immunity in the calf[J].Journal of Dairy Science,2016,99(5):3529-3538.
[81] GUO W J,ZHEN L,ZHANG J X,et al.Effect of feeding rumen-protected capsule containing niacin,K2SO4,vitamin C,and gamma-aminobutyric acid on heat stress and performance of dairy cows[J].Journal of Thermal Biology,2017,69:249-253.
[82] 陈志远,王剑飞,高健,等.过瘤胃烟酸对围产期奶牛生产性能和脂肪代谢的影响[J].中国奶牛,2018(4):10-13. CHEN Z Y,WANG J F,GAO J,et al.Effect of rumen-protected nicotinic acid on performance and fat metabolism of dairy cows[J].China Dairy Cattle,2018(4):10-13.(in Chinese)
[83] ZEITZ J O,WEBER A,MOST E,et al.Effects of supplementing rumen-protected niacin on fiber composition and metabolism of skeletal muscle in dairy cows during early lactation[J].Journal of Dairy Science,2018,101(9):8004-8020.
[84] LUO D,GAO Y F,LU Y Y,et al.Niacin alters the ruminal microbial composition of cattle under high-concentrate condition[J].Animal Nutrition,2017,3(2):180-185.
[85] 杨艳.烟酸对锦江牛瘤胃酸代谢和微生物区系的影响及预防酸中毒作用机理研究[D].博士学位论文.南昌:江西农业大学,2019. YANG Y.Study of the effects of niacin on acid metabolism and microflora in rumen of Jinjiang cattle and the mechanism of preventing acidosis[D].Ph.D.Thesis.Nanchang:Jiangxi Agricultural University,2019.(in Chinese)
[86] TAKEMOTO S,FUNABA M,MATSUI T.Effect of niacin supplementation in long-distance transported steer calves[J].Animal Science Journal,2018,89(10):1442-1450.
[87] TAKEMOTO S,TOMONAGA S,FUNABA M,et al.Effect of long-distance transportation on serum metabolic profiles of steer calves[J].Animal Science Journal,2017,88(12):1970-1978.
[88] LUO D,PENG Z,YANG L,et al.Niacin protects against butyrate-induced apoptosis in rumen epithelial cells[J].Oxidative Medicine and Cellular Longevity,2019,2019:2179738.
[89] 茹婷.基于p53-SIRT6-Fox01轴下烟酸对围产期绵羊肝脏糖异生作用的影响研究[D].硕士学位论文.呼和浩特:内蒙古农业大学,2018. RU T.Effect of nicotinic acid on liver glycosylation in perinatal ewes based on p53-SIRT6-Fox01 axis[D].Master's Thesis.Hohhot:Inner Mongolia Agricultural University,2018.(in Chinese)
[90] 刘秀梅.基于p53-SIRT6-Foxol轴下烟酸和非酯化脂肪酸对围产期羊肝细胞糖异生作用的影响研究[D].硕士学位论文.呼和浩特:内蒙古农业大学,2020. LIU X M.Study on the effect of p53-SIRT6-Foxo1 sub-axis niacin and non-esterified fatty acids on the gluconeogenesis of sheep liver cells in perinatal peri[D].Master's Thesis.Hohhot:Inner Mongolia Agricultural University,2020.(in Chinese)
