REVIEW

Roles of Natural Plant Components Regulating Gasdermin Family in Pyroptosis

  • SONG Jingping ,
  • JIANG Yuxuan ,
  • LIU Guangmang ,
  • WU Caimei
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  • Sichuan Key Laboratory of Animal Disease-Resistance Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition and Feedstuffs of China Ministry of Agriculture and Rural Affairs, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2021-12-10

  Online published: 2022-07-14

Abstract

Pyroptosis is a gasdermin (GSDM) family mediated programmed cell death and plays an important role in inflammatory bowel disease (IBD). Members of the GSDM family are activated to induce pyroptosis in inflammatory intestinal diseases, so the GSDM family may be a key protein regulating IBD signaling pathway. Some natural plant components with anti-inflammatory function can regulate the expression of GSDM family members, and then regulate pyroptosis and reduce inflammatory symptoms. The review summarized the roles of natural plant components regulating GSDM family in pyroptosis, aiming to provide new ideas for prevention and treatment of intestinal diseases and healthy breeding of livestock and poultry.

Cite this article

SONG Jingping , JIANG Yuxuan , LIU Guangmang , WU Caimei . Roles of Natural Plant Components Regulating Gasdermin Family in Pyroptosis[J]. Chinese Journal of Animal Nutrition, 2022 , 34(7) : 4213 -4226 . DOI: 10.3969/j.issn.1006-267x.2022.07.014

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