[1] WANG Y L,KIM R,HWANG S H J,et al.Analysis of interleukin 8 secretion by a stem-cell-derived human-intestinal-epithelial-monolayer platform[J].Analytical Chemistry,2018,90(19):11523-11530.
[2] ŠALAMON Š,KRAMAR B,MAROLT T P,et al.Medical and dietary uses of N-acetylcysteine[J].Antioxidants,2019,8(5):111.
[3] LIN X,WEI M M,SONG F Y,et al.N-acetylcysteine (NAC) attenuating apoptosis and autophagy in RAW264.7 cells in response to incubation with mycolic acid from bovine Mycobacterium tuberculosis complex[J].Polish Journal of Microbiology,2020,69(2):223-229.
[4] WOODHEAD K,FOEX B A.BET 1:in paracetamol overdose,is oral N-acetylcysteine as effective as intravenous N-acetylcysteine?[J].Emergency Medicine Journal,2018,35(10):643-645.
[5] ZHANG Q W,JU Y R,MA Y,et al.N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia:a randomized controlled trial[J].Medicine,2018,97(45):e13087.
[6] LEE S I,KANG K S.N-acetylcysteine modulates lipopolysaccharide-induced intestinal dysfunction[J].Scientific Reports,2019,9(1):1004.
[7] RAGHU G,BERK M,CAMPOCHIARO P A,et al.The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress[J].Current Neuropharmacology,2021,19(8):1202-1224.
[8] LUO J H,AO Z,DUAN Z Q,et al.Effects of N-acetylcysteine on the reproductive performance,oxidative stress and RNA sequencing of Nubian goats[J].Veterinary Medicine and Science,2021,7(1):156-163.
[9] 张成耀.由L-胱氨酸直接制备N-乙酰-L-半胱氨酸的工程研究[D].硕士学位论文.长春:吉林大学,2021:18-20.ZHANG C Y.Research on the direct preparation from L-cystine to N-acetyl-L-cysteine[D].Master's Thesis.Changchun:Jilin University,2021:18-20.(in Chinese)
[10] PEI Y P,LIU H,YANG Y,et al.Biological activities and potential oral applications of N-acetylcysteine:progress and prospects[J].Oxidative Medicine and Cellular Longevity,2018,2018:2835787.
[11] BALAJI S N,TRIVEDI V.Suicidal inactivation of methemoglobin by generation of thiyl radical:insight into NAC mediated protection in RBC[J].Current Molecular Medicine,2013,13(6):1000-1009.
[12] ALDINI G,ALTOMARE A,BARON G,et al.N-acetylcysteine as an antioxidant and disulphide breaking agent:the reasons why[J].Free Radical Research,2018,52(7):751-762.
[13] HIGASHI Y,ARATAKE T,SHIMIZU T,et al.Protective role of glutathione in the hippocampus after brain ischemia[J].International Journal of Molecular Sciences,2021,22(15):7765.
[14] DE CARO L,GHIZZI A,COSTA R,et al.Pharmacokinetics and bioavailability of oral acetylcysteine in healthy volunteers[J].Arzneimittelforschung,1989,39(3):382-386.
[15] BALAMURUGAN T S T,HUANG C H,CHANG P C,et al.Electrochemical molecular switch for the selective profiling of cysteine in live cells and whole blood and for the quantification of aminoacylase-1[J].Analytical Chemistry,2018,90(21):12631-12638.
[16] ESMAT A,EL-DEMERDASH E,EL-MESALLAMY H,et al.Toxicity and oxidative stress of acrylonitrile in rat primary glial cells:preventive effects of N-acetylcysteine[J].Toxicology Letters,2007,171(3):111-118.
[17] MARTIN D S,WILLIS S E,CLINE D M.N-acetylcysteine in the treatment of human arsenic poisoning[J].The Journal of the American Board of Family Practice,1990,3(4):293-296.
[18] FLORA S J.Arsenic-induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats[J].Clinical and Experimental Pharmacology&Physiology,1999,26(11):865-869.
[19] YEUNG Y T,AZIZ F,GUERRERO-CASTILLA A,et al.Signaling pathways in inflammation and anti-inflammatory therapies[J].Current Pharmaceutical Design,2018,24(14):1449-1484.
[20] CSONTOS C,REZMAN B,FOLDI V,et al.Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn[J].Burns,2012,38(3):428-437.
[21] KAR MAHAPATRA S,BHATTACHARJEE S,CHAKRABORTY S P,et al.Alteration of immune functions and Th1/Th2 cytokine balance in nicotine-induced murine macrophages:immunomodulatory role of eugenol and N-acetylcysteine[J].International Immunopharmacology,2011,11(4):485-495.
[22] MATA M,MORCILLO E,GIMENO C,et al.N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type Ⅱ epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)[J].Biochemical Pharmacology,2011,82(5):548-555.
[23] AOKI M,FUJISHITA T.Oncogenic roles of the PI3K/AKT/mTOR axis[J].Current Topics in Microbiology and Immunology,2017,407:153-189.
[24] CHEN S J,REN Q,ZHANG J F,et al.N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain[J].Neuropathology and Applied Neurobiology,2014,40(6):759-777.
[25] MICHAILIDIS Y,KARAGOUNIS L G,TERZIS G,et al.Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise[J].The American Journal of Clinical Nutrition,2013,98(1):233-245.
[26] EROSHENKO D,POLYUDOVA T,KOROBOV V.N-acetylcysteine inhibits growth,adhesion and biofilm formation of gram-positive skin pathogens[J].Microbial Pathogenesis,2017,105:145-152.
[27] EL-FEKY M A,EL-REHEWY M S,HASSAN M A,et al.Effect of ciprofloxacin and N-acetylcysteine on bacterial adherence and biofilm formation on ureteral stent surfaces[J].Polish Journal of Microbiology,2009,58(3):261-267.
[28] OLSON D H,BURRILL J S,KUZMICIC J,et al.Down regulation of peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2(mTORC2)[J].Biochemical and Biophysical Research Communications,2017,493(3):1311-1317.
[29] ZHAO T M,LIU Y N.N-acetylcysteine inhibit biofilms produced by Pseudomonas aeruginosa[J].BMC Microbiology,2010,10:140.
[30] LI X,KIM J,WU J B,et al.N-Acetyl-cysteine and mechanisms involved in resolution of chronic wound biofilm[J].Journal of Diabetes Research,2020,2020:9589507.
[31] CHANG Y C,YU Y H,SHEW J Y,et al.Deficiency of NPGPx,an oxidative stress sensor,leads to obesity in mice and human[J].EMBO Molecular Medicine,2013,5(8):1165-1179.
[32] LEE R,JUNG I,PARK M,et al.Real-time monitoring of adipocyte differentiation using a capacitance sensor array[J].Lab on a Chip,2013,13(17):3410-3416.
[33] XIAO M,YANG R,GUAN M J,et al.[Protective effects of N-acetyl-L-cysteine against binge drinking-induced fatty liver in mice] [J].Chinese Journal of Industrial Hygiene and Occupational Diseases,2018,36(3):169-173.
[34] 赵熠群,顾剑新,陈国.N-乙酰半胱氨酸对热应激蛋鸡生产指标及抗氧化指标的影响[J].畜牧与兽医,2018,50(2):31-35.ZHAO Y Q,GU J X,CHEN G.Effects of N-acetylcysteine on production and antioxidant indexes in heat stressed laying hens[J].Animal Husbandry&Veterinary Medicine,2018,50(2):31-35.(in Chinese)
[35] VALDIVIA A G,MARTÍNEZ A,DAMIÁN F J,et al.Efficacy of N-acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens[J].Poultry Science,2001,80(6):727-734.
[36] 王惠云,廖满,王蕾,等.N-乙酰半胱氨酸和冷应激对肉鸡肠道组织形态、能量代谢和抗氧化能力的影响[J].中国畜牧杂志,2018,54(2):52-59.WANG H Y,LIAO M,WANG L,et al.Effects of N-acetylcysteine and cold stress on intestinal morphology,energy status and antioxidant capacity in broilers[J].Chinese Journal of Animal Science,2018,54(2):52-59.(in Chinese)
[37] 杨淑霞,线萍,关樁慧.N-乙酰半胱氨酸对热应激条件下肉仔鸡生长性能、肠道能量和抗氧化状态及空肠形态的影响[J].中国饲料,2018(10):19-24.YANG S X,XIAN P,GUAN Z H.Effects of supplementation of N-acetylcysteine on growth performance,intestinal energy and antioxidation status,and intestinal morphology of broilers under heat-stressed[J].China Feed,2018(10):19-24.(in Chinese)
[38] 贺绍君,李静,刘德义.N-乙酰半胱氨酸对慢性热应激肉鸡肾脏功能损伤的缓解作用[J].黑龙江畜牧兽医,2017(24):158-160.HE S J,LI J,LIU D Y.Alleviated effects of N-acetylcysteine on renal function injury in heat stressed broilers[J].Heilongjiang Animal Science and Veterinary Medicine,2017(24):158-160.(in Chinese)
[39] 冯倩倩,王晶,武书庚,等.低蛋白质饲粮中添加半胱氨酸对肉仔鸡生长性能、胴体组成、血清生化指标及氮代谢的影响[J].动物营养学报,2021,33(6):3259-3270.FENG Q Q,WANG J,WU S G,et al.Effects of cysteine supplementation in low protein diet on growth performance,carcass composition,serum biochemical parameters and nitrogen metabolism of broilers[J].Chinese Journal of Animal Nutrition,2021,33(6):3259-3270.(in Chinese)
[40] 邱自贵,赵万乐,陈二平,等.含N-乙酰半胱氨酸稀释液对鸡精液低温保存效果的影响[J].畜牧与饲料科学,2016,37(8):27-29,34.QIU Z G,ZHAO W L,CHEN E P,et al.Effect of addition of N-acetyl-cysteine in the extender on cryo-preservation quality of chicken semen[J].Animal Husbandry and Feed Science,2016,37(8):27-29,34.(in Chinese)
[41] 李洁,董瑞生,王建福,等.稀释液中添加不同抗氧化剂对鸡精液保存的影响[J].甘肃畜牧兽医,2019,49(1):39-44.LI J,DONG R S,WANG J F,et al.Effects of different antioxidants on the preservation of chicken semen in diluent[J].Gansu Animal and Veterinary Sciences,2019,49(1):39-44.(in Chinese)
[42] 杨书慧,毕云天,程强,等.N-乙酰半胱氨酸对樱桃谷鸭肠道能量代谢和抗氧化功能的影响[J].中国畜牧杂志,2020,56(4):122-127.YANG S H,BI Y T,CHENG Q,et al.Effects of N-acetyl-cysteine on intestinal energy metabolism and antioxidant function of cherry valley duck[J].Chinese Journal of Animal Science,2020,56(4):122-127.(in Chinese)
[43] 谭灵琳,侯永清,易丹,等.N-乙酰半胱氨酸对肉鸭肝脏能量代谢状况及组织抗氧化指标的影响[J].中国畜牧杂志,2015,51(17):53-58.TAN L L,HOU Y Q,YI D,et al.Effects of N-actylcysteine on liver energy metabolic status and antioxidative capacity of ducks[J].Chinese Journal of Animal Science,2015,51(17):53-58.(in Chinese)
[44] YANG J P,SHIN J H,SEO S H,et al.Effects of antioxidants in reducing accumulation of fat in hepatocyte[J].International Journal of Molecular Sciences,2018,19(9):2563.
[45] 周佳,李鹏,程强,等.N-乙酰半胱氨酸灌胃对超早期断奶仔猪血浆中游离氨基酸及小肠形态结构与功能的影响[J].中国畜牧杂志,2018,54(4):50-54.ZHOU J,LI P,CHENG Q,et al.Effects of intragastric administration of N-acetylcysteine on plasma free amino acid composition and intestinal structure and function in ultral-early weaned pigs[J].Chinese Journal of Animal Science,2018,54(4):50-54.(in Chinese)
[46] WANG H Y,LI C C,PENG M,et al.N-acetylcysteine improves intestinal function and attenuates intestinal autophagy in piglets challenged with β-conglycinin[J].Scientific Reports,2021,11(1):1261.
[47] 李少华,罗振,罗文丽,等.不同抗氧化剂对断奶仔猪生产性能、抗氧化能力和免疫能力的影响[J].猪业科学,2017,34(3):87-89.LI S H,LUO Z,LUO W L,et al.Effects of different antioxidants on production performance,antioxidant capacity and immunity of weaned piglets[J].Swine Industry Science,2017,34(3):87-89.(in Chinese)
[48] 郭晓飞,张金龙,李义海,等.添加N-乙酰半胱氨酸对猪卵巢颗粒细胞体外培养的影响[J].黑龙江畜牧兽医,2020(23):59-62.GUO X F,ZHANG J L,LI Y H,et al.Effects of N-acetylcysteine on porcine ovarian granulosa cell culture in vitro[J].Heilongjiang Animal Science and Veterinary Medicine,2020(23):59-62.(in Chinese)
[49] HU X,CHENG L H,WANG X D,et al.N-acetyl-L-cysteine protects porcine oocytes undergoing meiotic resumption from heat stress[J].Reproductive Toxicology,2020,91:27-34.
[50] WHITAKER B D,KNIGHT J W.Effects of N-acetyl-cysteine and N-acetyl-cysteine-amide supplementation on in vitro matured porcine oocytes[J].Reproduction in Domestic Animals,2010,45(5):755-759.
[51] LAI F N,MA J Y,LIU J C,et al.The influence of N-acetyl-L-cysteine on damage of porcine oocyte exposed to zearalenone in vitro[J].Toxicology and Applied Pharmacology,2015,289(2):341-348.
[52] 宋天增,巴贵,次仁德吉,等.N-乙酰半胱氨酸对藏山羊母羊被公羊诱导发情效果与妊娠前期外周血液雌二醇和孕酮浓度的影响[J].西藏农业科技,2020,42(3):1-4.SONG T Z,BA G,CIRENDEJI,et al.Effects of NAC on induction of estrus synchronization in 2-year-old ewes by ram and levels of peripheral blood estradiol and progesterone of Tibetan goats during pre pregnancy[J].Tibet Journal of Agricultural Sciences,2020,42(3):1-4.(in Chinese)
[53] XU S S,GAO L,XIE X L,et al.Genome-wide association analyses highlight the potential for different genetic mechanisms for litter size among sheep breeds[J].Frontiers in Genetics,2018,9:118.
[54] YAN Y,FANG L L,LI Y X,et al.Association of MMP2 and MMP9 gene polymorphisms with the recurrent spontaneous abortion:a meta-analysis[J].Gene,2021,767:145173.
[55] 唐文,骆金红,敖叶,等.N-乙酰半胱氨酸对努比亚山羊PLCB3和MMP2基因表达的影响[J].黑龙江畜牧兽医,2020(13):12-16,21.TANG W,LUO J H,AO Y,et al.Effect of N-acetylcysteine on PLCB3,MMP2 gene expression in Nubian goats[J].Heilongjiang Animal Science and Veterinary Medicine,2020(13):12-16,21.(in Chinese)
[56] 李春阳,蔡元,臧荣鑫,等.N-乙酰半胱氨酸对绵羊精液低温保存效果的影响[J].黑龙江畜牧兽医,2020(13):59-61,67.LI C Y,CAI Y,ZANG R X,et al.Effect of adding N-acetylcysteine on low temperature preservation of sheep semen[J].Heilongjiang Animal Science and Veterinary Medicine,2020(13):59-61,67.(in Chinese)
