REVIEW

Molecular Regulation Mechanism of Silent Information Regulator 2-Related Enzyme 1 and Its Role in Inflammatory Diseases

  • MA Xuehu ,
  • AN Yanhao ,
  • DOU Wenli ,
  • MA Yanfen
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  • Key Laboratory of Ruminant Molecular Cell Breeding in Ningxia, School of Agriculture, Ningxia University, Yinchuan 750021, China

Received date: 2022-01-30

  Online published: 2022-08-11

Abstract

Silent information regulator 2-related enzyme 1 (SIRT1) is a member of the Sirtuin family of nicotinamide adenine dinucleotide (NAD+) dependent deacetylases. SIRT1 is closely related to inflammatory diseases such as neurodegenerative diseases, cardiovascular and cerebrovascular diseases, fatty liver and tumor diseases. The regulatory mechanism among the SIRT1 and tumor protein 53 (p53), nuclear factor-κB (NF-κB), adenosine monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), and the role of SIRT1 in inflammation were reviewed in this article, in order to provide technical support for the treatment of various inflammatory diseases.

Key words: SIRT1; p53; NF-κB; AMPK; PGC-1α

Cite this article

MA Xuehu , AN Yanhao , DOU Wenli , MA Yanfen . Molecular Regulation Mechanism of Silent Information Regulator 2-Related Enzyme 1 and Its Role in Inflammatory Diseases[J]. Chinese Journal of Animal Nutrition, 2022 , 34(8) : 4883 -4891 . DOI: 10.3969/j.issn.1006-267x.2022.08.015

References

[1] CACABELOS R,CARRIL J C,CACABELOS N,et al.Sirtuins in Alzheimer's disease:SIRT2-related genophenotypes and implications for pharmacoepigenetics[J].International Journal of Molecular Sciences,2019,20(5):1249.
[2] LEE D,GOLDBERG A L.SIRT1 protein,by blocking the activities of transcription factors FoxO1 and FoxO3,inhibits muscle atrophy and promotes muscle growth[J].Journal of Biological Chemistry,2013,288(42):30515-30526.
[3] CARAFA V,ROTILI D,FORGIONE M,et al.Sirtuin functions and modulation:from chemistry to the clinic[J].Clinical Epigenetics,2016,8:61.
[4] KUMAR A,CHAUHAN S.How much successful are the medicinal chemists in modulation of SIRT1:a critical review[J].European Journal of Medicinal Chemistry,2016,119:45-69.
[5] YANAGISAWA S,BAKER J R,VUPPUSETTY C,et al.The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure[J].PLoS One,2018,13(3):e0193921.
[6] SCHER M B,VAQUERO A,REINBERG D.SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress[J].Genes&Development,2007,21(8):920-928.
[7] DAVENPORT A M,HUBER F M,HOELZ A.Structural and functional analysis of human SIRT1[J].Journal of Molecular Biology,2014,426(3):526-541.
[8] WOJCIK M,MAC-MARCJANEK K,WOZNIAK L A.Physiological and pathophysiological functions of SIRT1[J].Mini Reviews in Medicinal Chemistry,2009,9(3):386-394.
[9] JIANG H,KHAN S,WANG Y,et al.SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine[J].Nature,2013,496(7443):110-113.
[10] ONG A L C,RAMASAMY T S.Role of sirtuin1-p53 regulatory axis in aging,cancer and cellular reprogramming[J].Ageing Research Reviews,2018,43:64-80.
[11] LAMICHANE S,BAEK S H,KIM Y J,et al.MHY2233 attenuates replicative cellular senescence in human endothelial progenitor cells via SIRT1 signaling[J].Oxidative Medicine and Cellular Longevity,2019,2019:6492029.
[12] KHANH V C,ZULKIFLI A F,TOKUNAGA C,et al.Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of sirtuin 1[J].Biochemical and Biophysical Research Communications,2018,500(3):682-690.
[13] POULOSE N,RAJU R.Sirtuin regulation in aging and injury[J].Biochimica et Biophysica Acta,2015,1852(11):2442-2455.
[14] LIU T,ZHANG L Y,JOO D,et al.NF-κB signaling in inflammation[J].Signal Transduction and Targeted Therapy,2017,2:17023.
[15] LUEDDE T,SCHWABE R F.NF-κB in the liver-linking injury,fibrosis and hepatocellular carcinoma[J].Nature Reviews Gastroenterology&Hepatology,2011,8(2):108-118.
[16] BAUD V,DERUDDER E.Control of NF-κB activity by proteolysis[J].Current Topics in Microbiology and Immunology,2011,349:97-114.
[17] KAUPPINEN A,SUURONEN T,OJALA J,et al.Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders[J].Cellular Signalling,2013,25(10):1939-1948.
[18] ROTHGIESSER K M,FEY M,HOTTIGER M O.Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression[J].BMC Genomics,2010,11:22.
[19] ZHAO H S,CHEN S R,GAO K,et al.Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway[J].Neuroscience,2017,348:241-251.
[20] GANESAN R,HOS N J,GUTIERREZ S,et al.Salmonella typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy[J].PLoS Pathogens,2017,13(2):e1006227.
[21] HOU J L,CHONG Z Z,SHANG Y C,et al.Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling,forkhead trafficking,bad,and mitochondrial caspase activation[J].Current Neurovascular Research,2010,7(2):95-112.
[22] CHANG C M,SU H,ZHANG D H,et al.AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation[J].Molecular Cell,2015,60(6):930-940.
[23] VILLENA J A.New insights into PGC-1 coactivators:redefining their role in the regulation of mitochondrial function and beyond[J].The FEBS Journal,2015,282(4):647-672.
[24] REN Z H,HE H Y,ZUO Z C,et al.The role of different SIRT1-mediated signaling pathways in toxic injury[J].Cellular&Molecular Biology Letters,2019,24:36.
[25] OLMOS Y,SÁNCHEZ-GÓMEZ F J,WILD B,et al.SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex[J].Antioxidants&Redox Signaling,2013,19(13):1507-1521.
[26] LAGOUGE M,ARGMANN C,GERHART-HINES Z,et al.Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha[J].Cell,2006,127(6):1109-1122.
[27] RODGERS J T,LERIN C,HAAS W,et al.Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1[J].Nature,2005,434(7029):113-118.
[28] CHEN D,BRUNO J,EASLON E,et al.Tissue-specific regulation of SIRT1 by calorie restriction[J].Genes&Development,2008,22(13):1753-1757.
[29] WANG Z,SUN W S,SUN X,et al.Kaempferol ameliorates Cisplatin induced nephrotoxicity by modulating oxidative stress,inflammation and apoptosis via ERK and NF-κB pathways[J].AMB Express,2020,10(1):58.
[30] DISABATO D J,QUAN N,GODBOUT J P.Neuroinflammation:the devil is in the details[J].Journal of Neurochemistry,2016,139(Suppl 2):136-153.
[31] ZHANG Y,ANOOPKUMAR-DUKIE S,ARORA D,et al.Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases[J].European Journal of Pharmacology,2020,867:172847.
[32] MAIESE K.Cognitive impairment with diabetes mellitus and metabolic disease:innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways[J].Expert Review of Clinical Pharmacology,2020,13(1):23-34.
[33] KHAN R S,FONSECA-KELLY Z,CALLINAN C,et al.SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells[J].Frontiers in Cellular Neuroscience,2012,6:63.
[34] YE J M,LIU Z H,WEI J P,et al.Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway[J].Neuroscience Letters,2013,553:72-77.
[35] ABE-HIGUCHI N,UCHIDA S,YAMAGATA H,et al.Hippocampal sirtuin 1 signaling mediates depression-like behavior[J].Biological Psychiatry,2016,80(11):815-826.
[36] LIBERT S,POINTER K,BELL E L,et al.SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive[J].Cell,2011,147(7):1459-1472.
[37] KILIC U,GOK O,BACAKSIZ A,et al.SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases[J].PLoS One,2014,9(2):e90428.
[38] CHEN Y X,ZHANG M,CAI Y H,et al.The Sirt1 activator SRT1720 attenuates angiotensin Ⅱ-induced atherosclerosis in apoE-/- mice through inhibiting vascular inflammatory response[J].Biochemical and Biophysical Research Communications,2015,465(4):732-738.
[39] PROLA A,PIRES DA SILVA J,GUILBERT A,et al.SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation[J].Cell Death and Differentiation,2017,24(2):343-356.
[40] STEIN S,MATTER C M.Protective roles of SIRT1 in atherosclerosis[J].Cell Cycle,2011,10(4):640-647.
[41] DOULAMIS I P,TZANI A I,KONSTANTOPOULOS P S,et al.A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease[J].International Journal of Cardiology,2017,230:447-453.
[42] VIKRAM A,LEWARCHIK C M,YOON J Y,et al.Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel[J].Nature Medicine,2017,23(3):361-367.
[43] MATSUSHIMA S,SADOSHIMA J.The role of sirtuins in cardiac disease[J].American Journal of Physiology.Heart and Circulatory Physiology,2015,309(9):H1375-H1389.
[44] ALCENDOR R R,GAO S M,ZHAI P Y,et al.Sirt1 regulates aging and resistance to oxidative stress in the heart[J].Circulation Research,2007,100(10):1512-1521.
[45] THOMPSON A M,WAGNER R,RZUCIDLO E M.Age-related loss of SirT1 expression results in dysregulated human vascular smooth muscle cell function[J].American Journal of Physiology.Heart and Circulatory Physiology,2014,307(4):H533-H541.
[46] KABRA N,LI Z Y,CHEN L H,et al.SirT1 is an inhibitor of proliferation and tumor formation in colon cancer[J].The Journal of Biological Chemistry,2009,284(27):18210-18217.
[47] REN N S X,JI M,TOKAR E J,et al.Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development[J].Current Biology,2017,27(4):483-494.
[48] CHUNG S Y,JUNG Y Y,PARK I A,et al.Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis,and poor disease-free survival in triple negative breast cancer[J].Clinical&Experimental Metastasis,2016,33(2):179-185.
[49] SIMMONS G E,Jr,PANDEY S,NEDELJKOVIC-KUREPA A,et al.Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells[J].PLoS One,2014,9(6):e98861.
[50] RODGERS J T,PUIGSERVER P.Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(31):12861-12866.
[51] LI Y,ZOU S P,DING H Y,et al.Low expression of sirtuin 1 in the dairy cows with mild fatty liver alters hepatic lipid metabolism[J].Animals,2020,10(4):560.
[52] YANG Y,BAI T,YAO Y L,et al.Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury[J].Toxicology Letters,2016,262:80-91.
[53] DU X L,YANG Y C,XU C,et al.Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis[J].Oncotarget,2017,8(53):91362-91378.
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