[1] MARIN S,RAMOS A J,CANO-SANCHO G,et al.Mycotoxins:occurrence,toxicology,and exposure assessment[J].Food and Chemical Toxicology,2013,60:218-237.
[2] 刘阳,张钊,郭双双,等.葛根提取物对产气荚膜梭菌感染肉鸡生长性能和肠道屏障功能的影响[J].中国畜牧杂志,2022,58(6):232-239. LIU Y,ZHANG Z,GUO S S,et al.Effect of pueraria extract on growth performance and intestinal barrier function in broilers challenged with
Clostridium perfringens[J].Chinese Journal of Animal Science,2022,58(6):232-239.(in Chinese)
[3] 杨俊,赵小刚,张桂红,等.呕吐毒素对畜禽肠道健康的影响及相关研究进展[J].中国饲料,2021(9):87-92. YANG J,ZHAO X G,ZHANG G H,et al.Effect and advances in research of deoxynivalenol on intestinal health of livestock and poultry[J].China Feed,2021(9):87-92.(in Chinese)
[4] 刘晓娜,孟小林,李泽宇.饲料中的营养物质对动物肠道功能和健康的调控作用[J].中国饲料,2022(8):9-12. LIU X N,MENG X L,LI Z N.Regulating function of dietary nutrients on intestinal function and health of animals[J].China Feed,2022(8):9-12.(in Chinese)
[5] NAKAGAWA H,HE X Y,MATSUO Y,et al.Analysis of the masked metabolite of deoxynivalenol and
Fusarium resistance in CIMMYT wheat germplasm[J].Toxins,2017,9(8):238.
[6] 郑云飞.不同储藏期稻谷品质、霉菌区系和真菌毒素的差异性研究[D].硕士学位论文.南京:南京财经大学,2020. ZHENG Y F.Study on the difference of rice quality,fungal flora and mycotoxins in different storage periods[D].Master's Thesis.Nanjing:Nanjing University of Finance&Economics,2020.(in Chinese)
[7] PALACIOS S A,ERAZO J G,CIASCA B,et al.Occurrence of deoxynivalenol and deoxynivalenol-3-glucoside in durum wheat from Argentina[J].Food Chemistry,2017,230:728-734.
[8] The Commission of the European Communities.Commission regulation (EC) No 1126/2007 of 28 September 2007 amending regulation (EC) No 1881/2006 setting maximum levels for certain contaminants in foodstuffs as regards
Fusarium toxins in maize and maize products[J].Official Journal of the European Union,2007,L255:14-17.
[9] PLEADIN J,FRECE J,LEŠI C'T,et al. Deoxynivalenol and zearalenone in unprocessed cereals and soybean from different cultivation regions in Croatia[J].Food Additives&Contaminants-Part B:Surveillance,2017,10(4):268-274.
[10] 丁燕玲,李孟聪,钟名琴,等.2015-2020年国内饲料霉菌毒素污染调查报告统计分析[J].中国动物检疫,2021,38(3):29-36. DING Y L,LI M C,ZHONG M Q,et al.Statistical analysis on the investigation reports concerning mycotoxin contamination in animal feed in China during 2015 to 2020[J].Chinese Journal of Animal Health Inspection,2021,38(3):29-36.(in Chinese)
[11] 中华人民共和国国家质量监督检验检疫总局,中国国家标准化管理委员会.饲料卫生标准:GB 13078-2017[S].北京:中国标准出版社,2017. General Administration of Quality Supervision,Inspection and Quarantine of the People's Republic of China,Standardization Administration of the People's Republic of China.Hygienical standard for feeds:GB 13078-2017[S].Beijing:Standards Press of China,2017.(in Chinese)
[12] SEEKATZ A M,SCHNIZLEIN M K,KOENIGSKNECHT M J,et al.Spatial and temporal analysis of the stomach and small-intestinal microbiota in fasted healthy humans[J].mSphere,2019,4(2):e00126-19.
[13] ROBERT H,PAYROS D,PINTON P,et al.Impact of mycotoxins on the intestine:are mucus and microbiota new targets?[J].Journal of Toxicology and Environmental Health-Part B:Critical Reviews,2017,20(5):249-275.
[14] 张聪.丁酸钠缓解呕吐毒素致断奶仔猪肠道损伤的效果及机制研究[D].硕士学位论文.武汉:华中农业大学,2021. ZHANG C.Effects of sodium butyrate on alleviating intestinal injury in weaned piglets exposed to deoxynivalenol[D].Master's Thesis.Wuhan:Huazhong Agricultural University,2021.(in Chinese)
[15] JIA W,XIE G X,JIA W P.Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis[J].Nature Reviews Gastroenterology&Hepatology,2018,15(2):111-128.
[16] WANG G,HUANG S,WANG Y M,et al.Bridging intestinal immunity and gut microbiota by metabolites[J].Cellular and Molecular Life Sciences,2019,76(20):3917-3937.
[17] DOU S,GADONNA-WIDEHEM P,ROME V,et al.Characterisation of early-life fecal microbiota in susceptible and healthy pigs to post-weaning diarrhoea[J].PLoS One,2017,12(1):e0169851.
[18] LI L,SU Q,XIE B,et al.Gut microbes in correlation with mood:case study in a closed experimental human life support system[J].Neurogastroenterology and Motility,2016,28(8):1233-1240.
[19] MACK I,CUNTZ U,GRÄMER C,et al.Weight gain in anorexia nervosa does not ameliorate the faecal microbiota,branched chain fatty acid profiles and gastrointestinal complaints[J].Scientific Reports,2016,6(1):26752.
[20] ZHENG W J,JI X,ZHANG Q,et al.Intestinal microbiota ecological response to oral administrations of hydrogen-rich water and lactulose in female piglets fed a
Fusarium toxin-contaminated diet[J].Toxins,2018,10(6):246.
[21] BANSIL R,TURNER B S.The biology of mucus:composition,synthesis and organization[J].Advanced Drug Delivery Reviews,2018,124:3-15.
[22] PELASEYED T,BERGSTRÖM J H,GUSTAFSSON J K,et al.The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system[J].Immunological Reviews,2014,260(1):8-20.
[23] JOHANSSON M E V,GUSTAFSSON J K,HOLMÉN-LARSSON J,et al.Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis[J].Gut,2014,63(2):281-291.
[24] BRACARENSE A P F L,LUCIOLI J,GRENIER B,et al.Chronic ingestion of deoxynivalenol and fumonisin,alone or in interaction,induces morphological and immunological changes in the intestine of piglets[J].British Journal of Nutrition,2012,107(12):1776-1786.
[25] LEWCZUK B,PRZYBYLSKA-GORNOWICZ B,GAJECKA M,et al.Histological structure of duodenum in gilts receiving low doses of zearalenone and deoxynivalenol in feed[J].Experimental and Toxicologic Pathology,2016,68(2/3):157-166.
[26] PINTON P,GRAZIANI F,PUJOL A,et al.Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase dependent repression of the resistin-like molecule β[J].Molecular Nutrition&Food Research,2015,59(6):1076-1087.
[27] SNOECK V,GODDEERIS B,COX E.The role of enterocytes in the intestinal barrier function and antigen uptake[J].Microbes and Infection,2005,7(7/8):997-1004.
[28] CAPALDO C T,NUSRAT A.Claudin switching:physiological plasticity of the tight junction[J].Seminars in Cell&Developmental Biology,2015,42:22-29.
[29] LIAO S M,TANG S G,TAN B,et al.Chloroquine improves deoxynivalenol-induced inflammatory response and intestinal mucosal damage in piglets[J].Oxidative Medicine and Cellular Longevity,2020,2020:9834813.
[30] PINTON P,NOUGAYRōDE J P,DEL RIO J C,et al.The food contaminant deoxynivalenol,decreases intestinal barrier permeability and reduces claudin expression[J].Toxicology and Applied Pharmacology,2009,237(1):41-48.
[31] KOLF-CLAUW M,CASTELLOTE J,JOLY B,et al.Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol:histopathological analysis[J].Toxicology
in Vitro,2009,23(8):1580-1584.
[32] PLUSKE J R,TURPIN D L,KIM J C.Gastrointestinal tract (gut) health in the young pig[J].Animal Nutrition,2018,4(2):187-196.
[33] HUANG C,FENG L,JIANG W D,et al.Deoxynivalenol decreased intestinal immune function related to NF-κB and TOR signalling in juvenile grass carp (
Ctenopharyngodon idella)[J].Fish&Shellfish Immunology,2019,84:470-484.
[34] LIAO P,LI Y H,LI M J,et al.Baicalin alleviates deoxynivalenol-induced intestinal inflammation and oxidative stress damage by inhibiting NF-κB and increasing mTOR signaling pathways in piglets[J].Food and Chemical Toxicology,2020,140:111326.
[35] 曹林,肖传明,冯秀燕,等.天然植物提取物对断奶仔猪生长性能、血清生化指标、抗氧化能力及免疫功能的影响[J].饲料研究,2022,45(9):40-44. CAO L,XIAO C M,FENG X Y,et al.Effect of natural plant extracts on growth performance,serum biochemical indexes,antioxidant capacity and immune function of weaning pigs[J].Feed Research,2022,45(9):40-44.(in Chinese)
[36] 唐茂妍,陈旭东.天然植物提取物替代饲用抗生素的应用研究进展[J].饲料博览,2018(12):17-22. TANG M Y,CHEN X D.Researches on the application of phytogenic feed additives substituted for antibiotics in animal feed[J].Feed Review,2018(12):17-22.(in Chinese)
[37] 曾建国.植物提取物及其饲料添加剂注册开发建议[J].饲料工业,2020,41(10):1-8. ZENG J G.Plant extracts and recommendations for the registration and development of plant extract feed additives[J].Feed Industry,2020,41(10):1-8.(in Chinese)
[38] TANG M,YUAN D X,LIAO P.Berberine improves intestinal barrier function and reduces inflammation,immunosuppression,and oxidative stress by regulating the NF-κB/MAPK signaling pathway in deoxynivalenol-challenged piglets[J].Environmental Pollution,2021,289:117865.
[39] YANG J,ZHU C,YE J L,et al.Protection of porcine intestinal-epithelial cells from deoxynivalenol-induced damage by resveratrol via the Nrf2 signaling pathway[J].Journal of Agricultural and Food Chemistry,2019,67(6):1726-1735.
[40] MARTÍNEZ G,DIÉGUEZ S N,FERNÁNDEZ PAGGI M B,et al.Effect of fosfomycin,
Cynara scolymus extract,deoxynivalenol and their combinations on intestinal health of weaned piglets[J].Animal Nutrition,2019,5(4):386-395.
[41] 许小向.甘草酸和益生菌组合缓解呕吐毒素危害断奶仔猪生长和肠道健康的分子机制[D].博士学位论文.郑州:河南农业大学,2021. XU X X.The molecular mechanism of combination of glycyrrhizic acid and probiotics for alleviating the hazards of weaned piglet growth and gut health induced by deoxynivalenol[D].Ph.D.Thesis.Zhengzhou:Henan Agricultural University,2021.(in Chinese)
[42] XU X X,CHANG J,WANG P,et al.Effect of chlorogenic acid on alleviating inflammation and apoptosis of IPEC-J2 cells induced by deoxyniyalenol[J].Ecotoxicology and Environmental Safety,2020,205:111376.
[43] XU X X,YAN G R,CHANG J,et al.Astilbin ameliorates deoxynivalenol-induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC-J2)[J].Journal of Applied Toxicology,2020,40(10):1362-1372.
[44] TAO Y,YUE M F,LV C J,et al.Pharmacological activation of ERβ by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases[J].The FASEB Journal,2020,34(2):3069-3090.
[45] WU Q H,LIU L,MIRON A,et al.The antioxidant,immunomodulatory,and anti-inflammatory activities of
Spirulina:an overview[J].Archives of Toxicology,2016,90(8):1817-1840.
[46] 程瑾,李澜鹏,罗中,等.脂肪酸分离技术研究进展[J].中国油脂,2018,43(11):49-53. CHENG J,LI L P,LUO Z,et al.Progress in separation of fatty acids[J].China Oils and Fats,2018,43(11):49-53.(in Chinese)
[47] WONG J M W,DE SOUZA R,KENDALL C W C,et al.Colonic health:fermentation and short chain fatty acids[J].Journal of Clinical Gastroenterology,2006,40(3):235-243.
[48] WANG Z H,WU Q H,KUČ A K,et al.Deoxynivalenol:signaling pathways and human exposure risk assessment-an update[J].Archives of Toxicology,2014,88(11):1915-1928.
[49] LIN R Q,SUN Y,MU P Q,et al.
Lactobacillus rhamnosus GG supplementation modulates the gut microbiota to promote butyrate production,protecting against deoxynivalenol exposure in nude mice[J].Biochemical Pharmacology,2020,175:113868.
[50] WANG S,ZHANG C,YANG J C,et al.Sodium butyrate protects the intestinal barrier by modulating intestinal host defense peptide expression and gut microbiota after a challenge with deoxynivalenol in weaned piglets[J].Journal of Agricultural and Food Chemistry,2020,68(15):4515-4527.
[51] HUANG C,SONG P X,FAN P X,et al.Dietary sodium butyrate decreases postweaning diarrhea by modulating intestinal permeability and changing the bacterial communities in weaned piglets[J].The Journal of Nutrition,2015,145(12):2774-2780.
[52] ZENTEK J,BUCHHEIT-RENKO S,MÄNNER K,et al.Intestinal concentrations of free and encapsulated dietary medium-chain fatty acids and effects on gastric microbial ecology and bacterial metabolic products in the digestive tract of piglets[J].Archives of Animal Nutrition,2012,66(1):14-26.
[53] XIAO K,LIU C C,QIN Q,et al.EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway[J].The FASEB Journal,2020,34(2):2483-2496.
[54] PAPADA E,KALIORA A C,GIOXARI A,et al.Anti-inflammatory effect of elemental diets with different fat composition in experimental colitis[J].British Journal of Nutrition,2014,111(7):1213-1220.
[55] 范觉鑫,刘志强,田雯,等.微量元素研究进展[J].饲料博览,2020(6):20-22. FAN J X,LIU Z Q,TIAN W,et al.Research progress of trace elements[J].Feed Review,2020(6):20-22.(in Chinese)
[56] WANG X M,ZUO Z C,DENG J L,et al.Protective role of selenium in immune-relevant cytokine and immunoglobulin production by piglet splenic lymphocytes exposed to deoxynivalenol[J].Biological Trace Element Research,2018,184(1):83-91.
[57] ZHA A D,TU R Q,CUI Z J,et al.Baicalin-zinc complex alleviates inflammatory responses and hormone profiles by microbiome in deoxynivalenol induced piglets[J].Frontiers in Nutrition,2021,8:738281.
[58] ZHA A D,YUAN D X,CUI Z J,et al.The evaluation of the antioxidant and intestinal protective effects of baicalin-copper in deoxynivalenol-challenged piglets[J].Oxidative Medicine and Cellular Longevity,2020,2020:5363546.
