[1] BARKER N,VAN ES J H,KUIPERS J,et al.Identification of stem cells in small intestine and colon by marker gene
Lgr5[J].Nature,2007,449(7165):1003-1007.
[2] DERRICOTT H,LUU L,FONG W Y,et al.Developing a 3D intestinal epithelium model for livestock species[J].Cell and Tissue Research,2019,375(2):409-424.
[3] HAMILTON C A,YOUNG R,JAYARAMAN S,et al.Development of
in vitro enteroids derived from bovine small intestinal crypts[J].Veterinary Research,2018,49(1):54.
[4] KHALIL H A,LEI N Y,BRINKLEY G,et al.A novel culture system for adult porcine intestinal crypts[J].Cell and Tissue Research,2016,365(1):123-134.
[5] GONZALEZ L M,WILLIAMSON I,PIEDRAHITA J A,et al.Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration[J].PLoS One,2013,8(6):e66465.
[6] PIERZCHALSKA M,GRABACKA M,MICHALIK M,et al.Prostaglandin E2 supports growth of chicken embryo intestinal organoids in Matrigel matrix[J].BioTechniques,2012,52(5):307-315.
[7] BARKER N.Adult intestinal stem cells:critical drivers of epithelial homeostasis and regeneration[J].Nature Reviews Molecular Cell Biology,2014,15:19-33.
[8] TIAN H,BIEHS B,WARMING S,et al.A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable[J].Nature,2011,478(7368):255-259.
[9] SATO T,VRIES R G,SNIPPERT H J,et al.Single Lgr5 stem cells build crypt-villus structures
in vitro without a mesenchymal niche[J].Nature,2009,459(7244):262-265.
[10] MERENDA A,FENDERICO N,MAURICE M M.Wnt signaling in 3D:recent advances in the applications of intestinal organoids[J].Trends in Cell Biology,2020,30(1):60-73.
[11] GEHART H,CLEVERS H.Tales from the crypt:new insights into intestinal stem cells[J].Nature Reviews Gastroenterology&Hepatology,2019,16(1):19-34.
[12] CARMON K S,LIN Q S,GONG X,et al.LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling[J].Molecular and Cellular Biology,2012,32(11):2054-2064.
[13] TAKAHASHI T,SHIRAISHI A.Stem cell signaling pathways in the small intestine[J].International Journal of Molecular Sciences,2020,21(6):2032.
[14] HARAMIS A P G,BEGTHEL H,VAN DEN BORN M,et al.
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine[J].Science,2004,303(5664):1684-1686.
[15] HE X C,ZHANG J W,TONG W G,et al.BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling[J].Nature Genetics,2004,36(10):1117-1121.
[16] KOSINSKI C,LI V S W,CHAN A S Y,et al.Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(39):15418-15423.
[17] LUDIKHUIZE M C,MEERLO M,GALLEGO M P,et al.Mitochondria define intestinal stem cell differentiation downstream of a FOXO/notch axis[J].Cell Metabolism,2020,32(5):889-900.e7.
[18] LIANG S J,LI X G,WANG X Q.Notch signaling in mammalian intestinal stem cells:determining cell fate and maintaining homeostasis[J].Current Stem Cell Research&Therapy,2019,14(7):583-590.
[19] SNIPPERT H J,VAN DER FLIER L G,SATO T,et al.Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells[J].Cell,2010,143(1):134-144.
[20] SHROYER N F,HELMRATH M A,WANG V Y C,et al.Intestine-specific ablation of mouse atonal homolog 1(
Math1) reveals a role in cellular homeostasis[J].Gastroenterology,2007,132(7):2478-2488.
[21] VANDUSSEN K L,SAMUELSON L C.Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate[J].Developmental Biology,2010,346(2):215-223.
[22] MO J S,PARK H W,GUAN K L.The hippo signaling pathway in stem cell biology and cancer[J].EMBO Reports,2014,15(6):642-656.
[23] BARRY E R,MORIKAWA T,BUTLER B L,et al.Restriction of intestinal stem cell expansion and the regenerative response by YAP[J].Nature,2013,493(7430):106-110.
[24] GREGORIEFF A,LIU Y,INANLOU M R,et al.Yap-dependent reprogramming of Lgr5
+ stem cells drives intestinal regeneration and cancer[J].Nature,2015,526(7575):715-718.
[25] PANEK M,GRABACKA M,PIERZCHALSKA M.The formation of intestinal organoids in a hanging drop culture[J].Cytotechnology,2018,70(3):1085-1095.
[26] MUSSARD E,POUZET C,HELIES V,et al.Culture of rabbit caecum organoids by reconstituting the intestinal stem cell niche
in vitro with pharmacological inhibitors or L-WRN conditioned medium[J].Stem Cell Research,2020,48:101980.
[27] VAN DER HEE B,LOONEN L M P,TAVERNE N,et al.Optimized procedures for generating an enhanced,near physiological 2D culture system from porcine intestinal organoids[J].Stem Cell Research,2018,28:165-171.
[28] LI L,FU F,GUO S S,et al.Porcine intestinal enteroids:a new model for studying enteric coronavirus porcine epidemic diarrhea virus infection and the host innate response[J].Journal of Virology,2019,93(5):e01682-18.
[29] ENGEVIK A C,COUTTS A W,KAJI I,et al.Editing myosin
VB gene to create porcine model of microvillus inclusion disease,with microvillus-lined inclusions and alterations in sodium transporters[J].Gastroenterology,2020,158(8):2236-2249.e9.
[30] LI J,LI J J,ZHANG S Y,et al.Culture and characterization of chicken small intestinal crypts[J].Poultry Science,2018,97(5):1536-1543.
[31] VAN DER HEE B,MADSEN O,VERVOORT J,et al.Congruence of transcription programs in adult stem cell-derived jejunum organoids and original tissue during long-term culture[J].Frontiers in Cell and Developmental Biology,2020,8:375.
[32] HOU Q H,HUANG J X,XIONG X,et al.Role of nutrient-sensing receptor GPRC6A in regulating colonic group 3 innate lymphoid cells and inflamed mucosal healing[J].Journal of Crohn's&Colitis,2022:jjac020.
[33] ZHU M,QIN Y C,GAO C Q,et al.
L-glutamate drives porcine intestinal epithelial renewal by increasing stem cell activity via upregulation of the EGFR-ERK-mTORC1 pathway[J].Food&Function,2020,11(3):2714-2724.
[34] WANG Z B,LI J,WANG Y,et al.Dietary vitamin A affects growth performance,intestinal development,and functions in weaned piglets by affecting intestinal stem cells[J].Journal of Animal Science,2020,98(2):skaa020.
[35] YIN L D,CHEN J F,LI L,et al.Aminopeptidase N expression,not interferon responses,determines the intestinal segmental tropism of porcine deltacoronavirus[J].Journal of Virology,2020,94(14):e00480-20.
[36] LI Y,YANG N,CHEN J N,et al.Next-generation porcine intestinal organoids:an apical-out organoid model for swine enteric virus infection and immune response investigations[J].Journal of Virology,2020,94(21):e01006-e01020.
[37] LUO H,ZHENG J Y,CHEN Y L,et al.Utility evaluation of porcine enteroids as PDCoV infection model
in vitro[J].Frontiers in Microbiology,2020,11:821.
[38] ALFAJARO M M,KIM J Y,BARB L,et al.Dual recognition of sialic acid and αGal epitopes by the VP8
* domains of the bovine rotavirus G6P
[5] WC3 and of its mono-reassortant G4P
[5] RotaTeq vaccine strains[J].Journal of Virology,2019,93(18):e00941-19.
[39] HOU Q H,YE L L,LIU H F,et al.
Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22[J].Cell Death and Differentiation,2018,25(9):1657-1670.
[40] WILLIAMSON I A,ARNOLD J W,SAMSA L A,et al.A high-throughput organoid microinjection platform to study gastrointestinal microbiota and luminal physiology[J].Cellular and Molecular Gastroenterology and Hepatology,2018,6(3):301-319.
[41] PIERZCHALSKA M,PANEK M,CZYRNEK M,et al.Probiotic
Lactobacillus acidophilus bacteria or synthetic TLR2 agonist boost the growth of chicken embryo intestinal organoids in cultures comprising epithelial cells and myofibroblasts[J].Comparative Immunology, Microbiology and Infectious Diseases,2017,53:7-18.
[42] BEAUMONT M,PAËS C,MUSSARD E,et al.Gut microbiota derived metabolites contribute to intestinal barrier maturation at the suckling-to-weaning transition[J].Gut Microbes,2020,11(5):1268-1286.
