RESEARCH PAPER

Effects of Coated Sodium Butyrate on Performance and Intestinal Health of Laying Hens

  • ZHANG Qi ,
  • ZHANG Keying ,
  • BAI Shiping ,
  • WANG Jianping ,
  • ZENG Qiufeng ,
  • PENG Huanwei ,
  • XUAN Yue ,
  • ZHANG Bo ,
  • DING Xuemei
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  • 1. Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China;
    2. Adisseo Life Science (Shanghai) Co., Ltd., Shanghai 201204, China

Received date: 2022-04-02

  Online published: 2022-10-17

Abstract

This experiment was conducted to investigate the effects of coated sodium butyrate (CSB) on performance, intestinal pH, digestive enzyme activities and related gene expression of laying hens. A total of 800 healthy Lohmann pink laying hens of 51-week-old were randomly divided into 4 groups with 10 replicates per group and 20 hens per replicate. Hens in the control group were fed a basal diet, and those in 3 experimental groups were fed the basal diet supplemented with 300, 500 and 800 mg/kg CSB, respectively. The trial lasted for 12 weeks. The results showed as follows: 1) different dietary levels of CSB linearly increased the laying rate of laying hens in weeks 5 to 8, 9 to 12 and 1 to 12 as well as the average daily feed intake in weeks 5 to 8 (P < 0.05), but had no significant effects on the average egg weight of laying hens (P>0.05). Compared with the control group, dietary 800 mg/kg CSB significantly decreased the feed to egg ratio of laying hens in weeks 9 to 12 and 1 to 12 (P < 0.05). Compared with 300 mg/kg CSB supplemental group, dietary 500 and 800 mg/kg CSB significantly increased the qualified egg rate of laying hens in weeks 1 to 4 and 5 to 8 (P < 0.05). 2) Compared with the control group, dietary 800 mg/kg CSB significantly decreased ileum pH of laying hens (P < 0.05); different dietary levels of CSB linearly decreased the pH in duodenum and jejunum of laying hens (P < 0.05). 3) Different dietary levels of CSB linearly increased the activities of trypsin and amylase in duodenum of laying hens (P < 0.05). 4) Compared with the control group, dietary 500 and 800 mg/kg CSB significantly decreased serum D-lactic acid content of laying hens (P < 0.05). 5) Compared with the control group, dietary CSB significantly decreased the mRNA relative expression level of interleukin-1β (IL-1β) in jejunum mucosa of laying hens (P < 0.05), and significantly increased the mRNA relative expression level of interleukin-10 (IL-10) in jejunum mucosa of laying hens (P < 0.05); dietary 300 and 500 mg/kg CSB significantly increased the mRNA relative expression level of mucin 2 (MUC2) in jejunum mucosa of laying hens (P < 0.05); different dietary levels of CSB linearly decreased the mRNA relative expression level of IL-1β in ileum mucosa of laying hens (P < 0.05), and linearly increased the mRNA relative expression level of zonula occluden-1 (ZO-1) in jejunum and ileum mucosa and the mRNA relative expression level of MUC2 in ileum mucosa of laying hens (P < 0.05). In conclusion, dietary 500 and 800 mg/kg CSB can improve the performance and intestinal health of laying hens.

Cite this article

ZHANG Qi , ZHANG Keying , BAI Shiping , WANG Jianping , ZENG Qiufeng , PENG Huanwei , XUAN Yue , ZHANG Bo , DING Xuemei . Effects of Coated Sodium Butyrate on Performance and Intestinal Health of Laying Hens[J]. Chinese Journal of Animal Nutrition, 2022 , 34(10) : 6502 -6513 . DOI: 10.3969/j.issn.1006-267x.2022.10.045

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