RESEARCH PAPER

Effects of Pueraria Polysaccharides on Basic Clinical Indices, Physiological and Biochemical Indices and Plasma Metabolites of Healthy Calves

  • SHEN Yu ,
  • LYU Shangkui ,
  • YOU Liuchao ,
  • FAN Lei ,
  • ZHANG Qiong ,
  • SU Zhetong ,
  • CAO Suizhong ,
  • YU Shumin ,
  • SHEN Liuhong
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  • 1. Medical Research Center for Cow Disease, Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;
    2. Guangxi Innovate Medical Technology Co., Ltd., Lipu 546600, China

Received date: 2022-07-14

  Online published: 2022-10-17

Abstract

This experiment was conducted to explore the effects of Pueraria polysaccharides on basic clinical indices, physiological and biochemical indices and plasma metabolites of healthy calves. Twenty-four healthy calves with similar age [(6.20±3.65) d] and body weight [(47.09±4.50) kg] were randomly divided into control group (group C) and test group (group E), each group contained 12 calves. Calves in group E were fed with 400 mg/kg Pueraria polysaccharides in the milk of each cow every day for 5 days, while the others in group C were not added. The body temperature, heart rate, respiratory rate of calves within 7 days, and body weight and diarrhea rate of calves within 21 days were observed and recorded. The routine blood indices, serum biochemical indices on days 1, 3, 5 and 7 and the plasma differential metabolites between two groups on day 7 were detected. The results showed as follows: 1) Pueraria polysaccharides had no significant effects on body temperature, heart rate, respiratory rate, routine blood indices, serum biochemical indices and body weight of calves (P>0.05). During days 1 to 7, days 8 to 14 and days 15 to 21, the body weight of calves of group E was higher than that of group C; during days 8 to 21, the diarrhea rates of calves of group C and group E were 5.36% and 0, respectively. 2) There were 14 differential metabolites were identified, among them, the abundances of diacylglycerol and citrulline which could promote intestinal development were significantly upregulated (P <0.05), while the abundances of lysophosphatidylcholine 18 ∶ 0 and biliverdin were significantly down-regulated (P <0.05), which had proinflammatory effect and involve the body antioxidant regulation, respectively. In conclusion, Pueraria polysaccharides have no significant clinical side effects on healthy calves, and it can regulate metabolism of healthy calves, promote intestinal development, enhance antioxidant capacity and reduce the inflammatory reaction, thus reduce the diarrhea and promote the growth of calves.

Cite this article

SHEN Yu , LYU Shangkui , YOU Liuchao , FAN Lei , ZHANG Qiong , SU Zhetong , CAO Suizhong , YU Shumin , SHEN Liuhong . Effects of Pueraria Polysaccharides on Basic Clinical Indices, Physiological and Biochemical Indices and Plasma Metabolites of Healthy Calves[J]. Chinese Journal of Animal Nutrition, 2022 , 34(10) : 6609 -6619 . DOI: 10.3969/j.issn.1006-267x.2022.10.054

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