INVITED REVIEW

Research Progress on mRNA N6-Methyladenosine Modification Regulation and Animal Fat Deposition

  • WANG Yizhen
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  • Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, National Engineering Research Center for Green Feed and Healthy Breeding, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China

Received date: 2022-09-01

  Online published: 2022-11-14

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Abstract

The development and deposition of adipose tissue are highly correlated with the growth, production, reproduction, health and meat quality of animals. Meanwhile, excessive fat deposition is also directly associated with the occurrence and development of human obesity and metabolic-related disease. Thus, how to regulate fat deposition is of great significance to improve animal growth performance and product quality, as well as human health. N6-methyladenosine (m6A) is one of the most important epigenetic modifications, which plays an essential role in regulating adipogenic stem cell differentiation and lipid metabolism. Based on an overview of the types of adipocytes, mRNA m6A methylation and its biological functions, this paper mainly reviewed the effects and regulatory mechanisms of mRNA m6A methylation on animal fat deposition, and discussed the recent research progress of nutrients in regulating animal fat deposition through mRNA m6A modification. Our work provides a theoretical basis and reference for accurately regulating animal fat deposition and promoting the high-quality development of animal husbandry.

Cite this article

WANG Yizhen . Research Progress on mRNA N6-Methyladenosine Modification Regulation and Animal Fat Deposition[J]. Chinese Journal of Animal Nutrition, 2022 , 34(11) : 6801 -6816 . DOI: 10.3969/j.issn.1006-267x.2022.11.001

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