REVIEW

Research Progress on Factors Affecting Intestinal Development of Lambs

  • ZHU Zhenyu ,
  • YANG Cheng ,
  • WANG Minggen ,
  • GUO Xuefeng
Expand
  • 1. College of Animal Science and Technology, Tarim University, Alar 843300, China;
    2. Tarim Key Laboratory of Animal Husbandry Science and Technology, Xinjiang Production and Construction Corps, Alar 843300, China

Received date: 2020-04-15

  Online published: 2022-11-14

Abstract

Intestinal development during the lamb period directly affects the performance of adulthood. The development of lambs' intestines is affected by a variety of factors, such as maternal nutrient level, feed energy, protein and fiber substances, and intestinal microorganisms, the feed energy and protein are the main influencing factors, and early energy and protein deficiency will inhibit the growth of intestinal tissue. This paper reviewed the structure and function of lambs' intestines, and the main factors affecting the development of lambs' intestines, provides a reference for the early scientific feeding methods of lambs, and puts forward prospects for the research direction of lambs' gastrointestinal tract.

Cite this article

ZHU Zhenyu , YANG Cheng , WANG Minggen , GUO Xuefeng . Research Progress on Factors Affecting Intestinal Development of Lambs[J]. Chinese Journal of Animal Nutrition, 2022 , 34(11) : 6894 -6903 . DOI: 10.3969/j.issn.1006-267x.2022.11.009

References

[1] 李贞, 王波, 李鹤琼, 等.反刍动物肠道发育过程及影响因素[J].现代畜牧兽医, 2018(11):30-33. LI Z, WANG B, LI H Q, et al.Intestinal development process and influencing factors of ruminants[J].Modern Journal of Animal Husbandry and Veterinary Medicine, 2018(11):30-33.(in Chinese)
[2] TRAHAIR J F, HARDING R, BOCKING A D, et al.The role of ingestion in the development of the small intestine in fetal sheep[J].Quarterly Journal of Experimental Physiology, 1986, 71(1):99-104.  
[3] WEAVER L T, AUSTIN S, COLE T J.Small intestinal length:a factor essential for gut adaptation[J].Gut, 1991, 32(11):1321-1323.  
[4] TRAHAIR J F, AVILA C G, ROBINSON P M.Growth of the fetal sheep small intestine[J].Growth, 1986, 50(2):201-216.
[5] TRAHAIR J F, DEBARRO T M, ROBINSON J S, et al.Restriction of nutrition in utero selectively inhibits gastrointestinal growth in fetal sheep[J].The Journal of Nutrition, 1997, 127(4):637-641.  
[6] CHONG C Y L, VATANEN T, OLIVER M, et al.The microbial biogeography of the gastrointestinal tract of preterm and term lambs[J].Scientific Reports, 2020, 10(1):9113.
[7] 王世琴, 李冲, 李发弟, 等.开食料中性洗涤纤维水平对哺乳羔羊生长性能和消化道发育的影响[J].动物营养学报, 2014, 26(8):2169-2175. WANG S Q, LI C, LI F D, et al.Effects of heutral detergent fiber level of starter on growth performance and digestive tract development of suckling lambs[J].Chinese Journal of Animal Nutrition, 2014, 26(8):2169-2175.(in Chinese)
[8] 段鹏伟, 刘婷, 李彦珍, 等.不同NDF来源开食料对湖羊羔羊生产性能和胃肠道发育的影响[J].草业科学, 2020, 37(8):1608-1619. DUAN P W, LIU T, LI Y Z, et al.Effects of different starters with different neutral detergent fiber sources on growth performance and gastrointestinal tract development of Hu lambs[J].Pratacultural Science, 2020, 37(8):1608-1619.(in Chinese)
[9] AMAGASE K, KIMURA Y, WADA A, et al.Prophylactic effect of monosodium glutamate on NSAID-induced enteropathy in rats[J].Current Pharmaceutical Design, 2014, 20(16):2783-2790.  
[10] YASUDA M, JENNE C N, KENNEDY L J, et al.The sheep and cattle Peyer's patch as a site of B-cell development[J].Veterinary Research, 2006, 37(3):401-415.  
[11] BAO C C, YUAN B Y, SUN M J, et al.Intestinal flora and its pathogenic mechanism in multiple sclerosis[J].Medical Journal of Chinese People's Liberation Army, 2018, 43(8):710-714.
[12] 魏志杰.奶山羊标准化生产与健康养殖关键技术[J].中国乳业, 2021(1):19-28. WEI Z J.The key technologies for standardized production and healthy breeding of dairy goats[J].China Dairy, 2021(1):19-28.(in Chinese)
[13] SHARIF L, OBEIDAT J, AL-ANI F.Risk factors for lamb and kid mortality in sheep and goat farms in Jordan[J].Bulgarian Journal of Veterinary Medicine, 2005, 8(2):99-108.
[14] MOHAMMAD H J, ALI K A, AL-ALI Z A J R.Histomorphologal and histochemical structure in the duodenum of sheep (Ovis aries) and rabbit (Oryctolagus cuniculus);a comparative study[J].Online Journal of Animal and Feed Research, 2020, 10(6):251-258.  
[15] PETERSON L W, ARTIS D.Intestinal epithelial cells:regulators of barrier function and immune homeostasis[J].Nature Reviews Immunology, 2014, 14(3):141-153.  
[16] WAN M L Y, LING K H, EL-NEZAMI H, et al.Influence of functional food components on gut health[J].Critical Reviews in Food Science and Nutrition, 2019, 59(12):1927-1936.  
[17] CONNOR E E, LI R W, BALDWIN R L, et al.Gene expression in the digestive tissues of ruminants and their relationships with feeding and digestive processes[J].Animal, 2010, 4(7):993-1007.  
[18] ALEKSANDERSEN M, HEIN W R, LANDSVERK T, et al.Distribution of lymphocyte subsets in the large intestinal lymphoid follicles of lambs[J].Immunology, 1990, 70(3):391-397.
[19] CAMPBELL J, BERRY J, LIANG Y.Chapter 71-anatomy and physiology of the small intestine[M]//YEO C J.Shackelford's surgery of the alimentary tract, 2 volume set.8th ed.Philadelphia:Elsevier, 2019:817-841.
[20] 王彩莲, 郎侠.放牧绵羊消化器官的发育性变化[J].中国草食动物科学, 2013, 33(1):21-25. WANG C L, LANG X.Developmental change of digestive organs in grazing sheep[J].China Herbivores, 2013, 33(1):21-25.(in Chinese)
[21] BALDWIN R L, MCLEOD K R, KLOTZ J L, et al.Rumen development, intestinal growth and hepatic metabolism in the pre- and postweaning ruminant[J].Journal of Dairy Science, 2004, 87(Suppl.):E55-E65.
[22] WANG J, YU X J, BAI Y Y, et al.Effects of grazing and confinement on the morphology and microflora of the gastrointestinal tract of small-tailed Han sheep[J].Livestock Science, 2020, 241:104208.
[23] KHANAL P, D. AXEL A M, SAFAYI S, et al.Prenatal over- and undernutrition differentially program small intestinal growth, angiogenesis, absorptive capacity, and endocrine function in sheep[J].Physiological Reports, 2020, 8(12):e14498.
[24] FLORES T J, NGUYEN V B, WIDDOP R E, et al.Morphology and function of the lamb ileum following preterm birth[J].Frontiers in Pediatrics, 2018, 6:8.
[25] KIELA P R, GHISHAN F K.Physiology of intestinal absorption and secretion[J].Best Practice & Research Clinical Gastroenterology, 2016, 30(2):145-159.  
[26] MÖLLER P, WALCZAK H, REIDL S, et al.Paneth cells express high levels of CD95 ligand transcripts:a unique property among gastrointestinal epithelia[J].The American Journal of Pathology, 1996, 149(1):9-13.
[27] 杨玉荣, 焦喜兰, 梁宏德.潘氏细胞及其防御素的研究进展[J].中国细胞生物学学报, 2010, 32(6):971-975. YANG Y R, JIAO X L, LIANG H D.Progress in Paneth cell α-defensin[J].Chinese Journal of Cell Biology, 2010, 32(6):971-975.(in Chinese)
[28] KORPE P S, PETRI W A, Jr.Environmental enteropathy:critical implications of a poorly understood condition[J].Trends in Molecular Medicine, 2012, 18(6):328-336.  
[29] 吴晶.中草药饲料添加剂在绵羊生产中的研究进展[J].畜牧与饲料科学, 2012, 33(2):30-31. WU J.Research progress of Chinese herbal feed additives in sheep production[J].Animal Husbandry and Feed Science, 2012, 33(2):30-31.(in Chinese)
[30] DIXON R M, NOLAN J V.Studies of the large intestine of sheep.1.Fermentation and absorption in sections of the large intestine[J].British Journal of Nutrition, 1982, 47(2):289-300.  
[31] 秦龙, 姜宁, 张爱忠, 等.Cec Md衍生肽对羔羊盲肠组织、黏膜形态及腹泻的影响[J].黑龙江畜牧兽医, 2019(1):96-99, 181. QIN L, JIANG N, ZHANG A Z, et al.Effect of Cec Md derived peptide on caecal tissue, mucosal morphology and diarrhea in lambs[J].Heilongjiang Animal Science and Veterinary Medicine, 2019(1):96-99, 181.(in Chinese)
[32] XIAO J X, ALUGONGO G M, CHUNG R, et al.Effects of Saccharomyces cerevisiae fermentation products on dairy calves:ruminal fermentation, gastrointestinal morphology, and microbial community[J].Journal of Dairy Science, 2016, 99(7):5401-5412.  
[33] OWENS F N, DUBESKI P, HANSON C F.Factors that alter the growth and development of ruminants[J].Journal of Animal Science, 1993, 71(11):3138-3150.  
[34] CELI P, VERLHAC V, PÉREZ CALVO E, et al.Biomarkers of gastrointestinal functionality in animal nutrition and health[J].Animal Feed Science and Technology, 2019, 250:9-31.
[35] HERATH H M G P, PAIN S J, KENYON P R, et al.Growth and body composition of artificially-reared lambs exposed to three different rearing regimens[J].Animals, 2021, 11(12):3370.
[36] MEYER A M, CATON J S.Role of the small intestine in developmental programming:impact of maternal nutrition on the dam and offspring[J].Advances in Nutrition, 2016, 7(1):169-178.  
[37] ZHAO M D, DI L F, TANG Z Y, et al.Effect of tannins and cellulase on growth performance, nutrients digestibility, blood profiles, intestinal morphology and carcass characteristics in Hu sheep[J].Asian-Australasian Journal of Animal Sciences, 2019, 32(10):1540-1547.  
[38] GUILLOTEAU P, CORRING T, GARNOT P, et al.Effects of age and weaning on enzyme activities of abomasum and pancreas of the lamb[J].Journal of Dairy Science, 1983, 66(11):2373-2385.  
[39] LI C, WANG W M, LIU T, et al.Effect of early weaning on the intestinal microbiota and expression of genes related to barrier function in lambs[J].Frontiers in Microbiology, 2018, 9:1431.
[40] CUI K, QI M L, WANG S Q, et al.Dietary energy and protein levels influenced the growth performance, ruminal morphology and fermentation and microbial diversity of lambs[J].Scientific Reports, 2019, 9(1):16612.
[41] LEEMING E R, JOHNSON A J, SPECTOR T D, et al.Effect of diet on the gut microbiota:rethinking intervention duration[J].Nutrients, 2019, 11(12):2862.
[42] SWANSON T J, HAMMER C J, LUTHER J S, et al.Effects of gestational plane of nutrition and selenium supplementation on mammary development and colostrum quality in pregnant ewe lambs[J].Journal of Animal Science, 2008, 86(9):2415-2423.  
[43] VONNAHME K A, HESS B W, HANSEN T R, et al.Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep[J].Biology of Reproduction, 2003, 69(1):133-140.  
[44] 孙玲伟, 王智博, 安世钰, 等.RP-Arg和NCG对营养限饲湖羊胎盘发育的影响[J].南京农业大学学报, 2020, 43(1):125-133. SUN L W, WANG Z B, AN S Y, et al.Effects of dietary RP-Arg and NCG supplementation on development of maternal and fetal placenta in nutrient restriction Hu sheep during pregnancy[J].Journal of Nanjing Agricultural University, 2020, 43(1):125-133.(in Chinese)
[45] AVILA C G, HARDING R, REES S, et al.Small intestinal development in growth-retarded fetal sheep[J].Journal of Pediatric Gastroenterology and Nutrition, 1989, 8(4):507-515.  
[46] BRACE R A.Physiology of amniotic fluid volume regulation[J].Clinical Obstetrics and Gynecology, 1997, 40(2):280-289.  
[47] TRAHAIR J F, HARDING R.Restitution of swallowing in the fetal sheep restores intestinal growth after midgestation esophageal obstruction[J].Journal of Pediatric Gastroenterology and Nutrition, 1995, 20(2):156-161.  
[48] HARDING J E, JONES C T, ROBINSON J S.Studies on experimental growth retardation in sheep.The effects of a small placenta in restricting transport to and growth of the fetus[J].Journal of Developmental Physiology, 1985, 7(6):427-442.
[49] GIRARD J.Carbohydrate metabolism during fetal development[M]//KVNZEL W, JENSEN A.The endocrine control of the fetus.Berlin:Springer, 1988:323-332.
[50] HE Z X, SUN Z H, LIU S M, et al.Effects of early malnutrition on mental system, metabolic syndrome, immunity and the gastrointestinal tract[J].The Journal of Veterinary Medical Science, 2009, 71(9):1143-1150.  
[51] DISTEL R A, VILLALBA J J, LABORDE H E.Effects of early experience on voluntary intake of low-quality roughage by sheep[J].Journal of Animal Science, 1994, 72(5):1191-1195.  
[52] BURTON J H, ANDERSON M, REID J T.Some biological aspects of partial starvation.The effect of weight loss and regrowth on body composition in sheep[J].British Journal of Nutrition, 1974, 32(3):515-527.  
[53] LIMA H B, COSTA R G, DIAS-SILVA T P, et al.Performance and ruminal and intestinal morphometry of Santa Inês sheep submitted to feed restriction and refeeding[J].Tropical Animal Health and Production, 2022, 54(1):42.
[54] BOSI P, GREMOKOLINI C, TREVISI P.Dietary regulations of the intestinal barrier function at weaning[J].Asian-Australasian Journal of Animal Sciences, 2003, 16(4):596-608.  
[55] 于洋洋.不同淀粉源对羔羊小肠发育、消化酶活性及相关基因表达量的影响[D].硕士学位论文.大庆:黑龙江八一农垦大学, 2018:17-29. YU Y Y.Effects of different starch sources on intestinal development, digestive enzyme activities and related gene expression in lambs[D].Master's Thesis.Daqing:Heilongjiang Bayi Agricultural University, 2018:17-29.(in Chinese)
[56] 于杰, 王谊鹃.饲粮精粗比对反刍动物生产和经济效益的影响[J].饲料研究, 2021, 44(9):156-159. YU J, WANG Y J.Effect of concentrate to roughage ratio on ruminant production and economic benefit[J].Feed Research, 2021, 44(9):156-159.(in Chinese)
[57] WANG Q Y, WANG Y C, WANG X, et al.Effects of dietary energy levels on rumen fermentation, microbiota, and gastrointestinal morphology in growing ewes[J].Food Science & Nutrition, 2020, 8(12):6621-6632.  
[58] PATRA A K, ASCHENBACH J R.Ureases in the gastrointestinal tracts of ruminant and monogastric animals and their implication in urea-N/ammonia metabolism:a review[J].Journal of Advanced Research, 2018, 13:39-50.
[59] 张毕红, 苏展, 胡小芳, 等.粗饲料的品质对反刍动物生产性能的影响[J].饲料研究, 2011(9):60-62. ZHANG B H, SU Z, HU X F, et al.Effects of roughages quality on ruminant performance[J].Feed Research, 2011(9):60-62.(in Chinese)
[60] WANG L, ZHANG K, ZHANG C G, et al.Dynamics and stabilization of the rumen microbiome in yearling Tibetan sheep[J].Scientific Reports, 2019, 9(1):19620.
[61] 周力, 张峰硕, 张春梅, 等.日粮精粗比对青海黑藏羊小肠营养物质转运载体基因表达水平的影响[J].四川农业大学学报, 2022, 40(1):105-110, 136. ZHOU L, ZHANG F S, ZHANG C M, et al.Effects of dietary forage to concentrate ratio on gene expression level of nutrient transporter in small intestine of Qinghai black Tibetan sheep[J].Journal of Sichuan Agricultural University, 2022, 40(1):105-110, 136.(in Chinese)
[62] CHENG J B, WANG W M, ZHANG D Y, et al.Distribution and difference of gastrointestinal flora in sheep with different body mass index[J].Animals, 2022, 12(7):880.
[63] MA N, MA X.Dietary amino acids and the gut-microbiome-immune axis:physiological metabolism and therapeutic prospects[J].Comprehensive Reviews in Food Science and Food Safety, 2019, 18(1):221-242.  
[64] LIU G M, CAO W, JIA G, et al.Calcium-sensing receptor in nutrient sensing:an insight into the modulation of intestinal homoeostasis[J].British Journal of Nutrition, 2018, 120(8):881-890.  
[65] BUNTYN J O, SCHMIDT T B, NISBET D J, et al.The role of direct-fed microbials in conventional livestock production[J].Annual Review of Animal Biosciences, 2016, 4:335-355.
[66] BI Y L, TU Y, ZHANG N F, et al.Multiomics analysis reveals the presence of a microbiome in the gut of fetal lambs[J].Gut, 2021, 70(5):853-864.  
[67] SZELIGOWSKA N, CHOLEWI SKA P, SMOLIÑSKI J, et al.Glutathione S-transferase (GST) and cortisol levels vs. microbiology of the digestive system of sheep during lambing[J].BMC Veterinary Research, 2022, 18(1):107.
[68] BAILLOU A, KASAL-HOC N, BARC C, et al.Establishment of a newborn lamb gut-loop model to evaluate new methods of enteric disease control and reduce experimental animal use[J].Veterinary Sciences, 2021, 8(9):170.
[69] ZHANG H, SHAO M X, HUANG H, et al.The dynamic distribution of small-tail Han sheep microbiota across different intestinal segments[J].Frontiers in Microbiology, 2018, 9:32.
[70] STANLEY D, HUGHES R J, MOORE R J.Microbiota of the chicken gastrointestinal tract:influence on health, productivity and disease[J].Applied Microbiology and Biotechnology, 2014, 98(10):4301-4310.  
[71] WANG S Q, MA T, ZHAO G H, et al.Effect of age and weaning on growth performance, rumen fermentation, and serum parameters in lambs fed starter with limited ewe-lamb interaction[J].Animals, 2019, 9(10):825.
[72] 韩铖星, 张成新, 李勇, 等.湖羊羔羊早期断奶前后胃肠道发育、酶活性及发酵参数的变化研究[J].中国畜牧兽医, 2021, 48(12):4442-4450. HAN C X, ZHANG C X, LI Y, et al.Study on variations of gastrointestinal development, enzyme activity and fermentation parameters of Hu lambs pre-and post-early weaning[J].China Animal Husbandry & Veterinary Medicine, 2021, 48(12):4442-4450.(in Chinese)
[73] 卢猛, 胡凤明, 屠焰, 等.植物提取物对幼龄动物腹泻和肠道健康的作用[J].饲料工业, 2021, 42(15):35-42. LU M, HU F M, TU Y, et al.Effects of plant extracts on diarrhea and intestinal health of young animals[J].Feed Industry, 2021, 42(15):35-42.(in Chinese)
[74] DENG Z X, HOU K W, ZHAO J C, et al.The probiotic properties of lactic acid bacteria and their applications in animal husbandry[J].Current Microbiology, 2021, 79(1):22.
[75] SONG C J, SHEN X Y.Effects of environmental zinc deficiency on antioxidant system function in Wumeng semi-fine wool sheep[J].Biological Trace Element Research, 2020, 195(1):110-116.  
[76] CORRÊA P S, MENDES L W, LEMOS L N, et al.Tannin supplementation modulates the composition and function of ruminal microbiome in lambs infected with gastrointestinal nematodes[J].FEMS Microbiology Ecology, 2020, 96(3):fiaa024.
[77] DING S J, YAN W X, MA Y, et al.The impact of probiotics on gut health via alternation of immune status of monogastric animals[J].Animal Nutrition, 2021, 7(1):24-30.  
[78] JOHNSON L R.The trophic action of gastrointestinal hormones[J].Gastroenterology, 1976, 70(2):278-288.  
[79] 秦颖超, 周加义, 朱敏, 等.谷氨酸吸收转运及对肠道发育影响的研究进展[J].动物营养学报, 2019, 31(2):544-552. QIN Y C, ZHOU J Y, ZHU M, et al.Research progress of glutamate absorption and transport and its effects on intestinal development[J].Chinese Journal of Animal Nutrition, 2019, 31(2):544-552.(in Chinese)
[80] RAHMAN S, GHIBOUB M, DONKERS J M, et al.The progress of intestinal epithelial models from cell lines to gut-on-chip[J].International Journal of Molecular Sciences, 2021, 22(24):13472.
[81] SATO T, VRIES R G, SNIPPERT H J, et al.Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche[J].Nature, 2009, 459(7244):262-265.  
[82] SEIDLITZ T, KOO B K, STANGE D E.Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine[J].Cell Death and Differentiation, 2021, 28(1):68-83.  
[83] ALMEQDADI M, MANA M D, ROPER J, et al.Gut organoids:mini-tissues in culture to study intestinal physiology and disease[J].American Journal of Physiology.Cell Physiology, 2019, 317(3):C405-C419.
[84] STEVENS L J, VAN LIPZIG M M H, ERPELINCK S L A, et al.A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes[J].European Journal of Pharmaceutical Sciences, 2019, 137:104989.
[85] VERHOECKX K, COTTER P, LÓPEZ-EXPÓSITO I, et al.The impact of food bioactives on health:in vitro and ex vivo models[M].Cham:Springer, 2015:263-273.
[86] ESLAMI AMIRABADI H, DONKERS J M, WIERENGA E, et al.Intestinal explant barrier chip:long-term intestinal absorption screening in a novel microphysiological system using tissue explants[J].Lab on a Chip, 2022, 22(2):326-342.  
[87] DONKERS J M, ESLAMI AMIRABADI H, VAN DE STEEG E.Intestine-on-a-chip:next level in vitro research model of the human intestine[J].Current Opinion in Toxicology, 2021, 25:6-14.
[88] WANG X, YAMAMOTO Y, WILSON L H, et al.Cloning and variation of ground state intestinal stem cells[J].Nature, 2015, 522(7555):173-178.  
[89] HOFER M, LUTOLF M P.Engineering organoids[J].Nature Reviews.Materials, 2021, 6(5):402-420.  
[90] 朱晓芳, 吴静静, 桑断疾, 等.羔羊断奶补饲技术应用研究进展[J].养殖与饲料, 2020, 19(11):48-49. ZHU X F, WU J J, SANG D J, et al.Research progress in the application of supplementary feeding technology for lamb weaning[J].Animals Breeding and Feed, 2020, 19(11):48-49.(in Chinese)
[91] DA SILVA HEIMBACH N, ÍTAVO C C B F, ÍTAVO L C V, et al.Weaning age of lambs creep-fed while grazing on Marandu pasture[J].Journal of Agricultural Studies, 2019, 7(4):22-37.  
[92] 王志有.早期断奶日龄对羔羊生产性能的影响[J].黑龙江畜牧兽医, 2004(6):26-27. WANG Z Y.Effects of early weaning age on lamb production performance[J].Heilongjiang Animal Science and Veterinary Medicine, 2004(6):26-27.(in Chinese)
[93] SIMEONOV M S, HARMON D L.Effects of nutritional systems on early weaned lambs[J].Iranian Journal of Applied Animal Science, 2021, 11(1):111-116.
[94] 柴建民, 王波, 祁敏丽, 等.不同开食料采食量断液体饲粮对羔羊生长发育的影响[J].中国农业科学, 2018, 51(2):341-350. CHAI J M, WANG B, QI M L, et al.Effect of weaning liquid diet at different level of creep feed intake on growth and development of lambs[J].Scientia Agricultura Sinica, 2018, 51(2):341-350.(in Chinese)
Outlines

/