Interventional Effect of Eucommia ulmoides Flavones on Growth Inhibition, Oxidative Stress Injury and Inflammatory Injury of Weaned Piglets Induced by Deoxynivalenol

YUAN Daixiu; TAN Bi'e; ZHA Andong; LIAO Peng

doi:10.3969/j.issn.1006-267x.2022.11.016

2022 , Vol. 34 >Issue 11: 6953 - 6961

DOI: https://doi.org/10.3969/j.issn.1006-267x.2022.11.016

RESEARCH PAPER

Interventional Effect of Eucommia ulmoides Flavones on Growth Inhibition, Oxidative Stress Injury and Inflammatory Injury of Weaned Piglets Induced by Deoxynivalenol

YUAN Daixiu ,
TAN Bi'e ,
ZHA Andong ,
LIAO Peng

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1. Department of Medicine, Jishou University, Jishou 416000, China;
2. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
3. Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China

Received date: 2022-04-20

Online published: 2022-11-14

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Abstract

This experiment was conducted to explore the intervention effect of Eucommia ulmoides flavones (EUF) on growth inhibition, oxidative stress injury and inflammatory injury of weaned piglets induced by deoxynivalenol (DON). Twenty-four healthy three crossbred (Duroc×Landrace×Yorkshire) weaned piglets with an initial body weight of (6.50±0.28) kg were randomly divided into 3 groups, they were control group (basal diet), DON group (diet contained 1.5 mg/kg DON) and DON+EUF group (diet contained 1.5 mg/kg DON and 100 mg/kg EUF) with 8 piglets in each group, each of which was a repeat. The formal experiment lasted for 21 days after 7 days adaptation. The results showed as follows:1) compared with the control group, the final body weight, average daily gain (ADG) and average daily feed intake (ADFI) of piglets in the DON group were significantly decreased (P<0.05), and the feed/gain ratio (F/G) was significantly increased (P<0.05); there were no significant differences in ADG, ADFI and F/G between the DON+EUF group and control group (P>0.05). The ADG of piglets in the DON+EUF group was significantly higher than that in the DON group (P<0.05), but the F/G was significantly lower than that in the DON group (P<0.05). Compared with the control group, the relative indexes of liver and spleen in the DON group was significantly increased (P<0.05). 2) Compared with the control group, the activities of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the DON group were significantly increased (P<0.05). The activity of serum ALP in the DON+EUF group as significantly lower than that in the DON group (P<0.05). 3) Compared with control group, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) in the DON group were significantly decreased (P<0.05), and the contents of malondialdehyde (MDA) and reactive oxygen species (ROS) were significantly increased (P<0.05). Compared with the DON group, the activities of serum SOD and GSH-Px in the DON+EUF group were significantly increased (P<0.05), and the contents of MDA and ROS were significantly decreased (P<0.05). Compared with the control group, the contents of serum interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the DON group were significantly increased. The contents of IL-6, IL-1β and TNF-α in serum in the DON+EUF group were significantly reduced compared with the DON group (P<0.05). In conclusion, dietary supplementation with EUF has a certain effect on alleviating growth inhibition, liver and spleen lesions, and improving antioxidant capacity and anti-inflammatory capacity of weaned piglets induced by DON.

Key words： deoxynivalenol; weaned piglets; antioxidant function; inflammatory injury; interventional effect

Cite this article

YUAN Daixiu , TAN Bi'e , ZHA Andong , LIAO Peng . Interventional Effect of Eucommia ulmoides Flavones on Growth Inhibition, Oxidative Stress Injury and Inflammatory Injury of Weaned Piglets Induced by Deoxynivalenol[J]. Chinese Journal of Animal Nutrition, 2022 , 34(11) : 6953 -6961 . DOI: 10.3969/j.issn.1006-267x.2022.11.016

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