RESEARCH PAPER

Effects of Mycotoxin Adsorbent-Organic Acid Complex and Mycotoxin Adsorbent-Essential Oil Complex on Intestinal Mucosal Barrier Function of Laying Hens

  • CHEN Jifa ,
  • ZHANG Jiaxin
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  • Selenium Agricultural Engineering Technology Research Center of Jiangxi Provincial Colleges and Universities, College of Life Science and Resources and Environment, Yichun University, Yichun 336000, China

Received date: 2021-11-18

  Online published: 2022-11-14

Abstract

This study was conducted to investigate the effects of mycotoxin adsorbent (MA)-organic acid (OA) complex and MA-essential oil (EO) complex on intestinal mucosal barrier function of laying hens. A total of 270 healthy 29-week-old laying hens were randomly divided into 3 groups with 6 replicates per group and 15 hens per replicate. Hens in the control group were fed a basal diet, and hens in the test groups were fed the basal diet supplemented with 0.65 g/kg MA-OA complex and 0.70 g/kg MA-EO complex, respectively. The adjustment period lasted for 1 week, and the experimental period lasted for 10 weeks. The results showed as follows:compared with the control group, dietary supplemented with both MA-OA complex or MA-EO complex significantly reduced the relative amount of Clostridium perfringens in ileum (P<0.05), and significantly down-regulated the mRNA relative expression levels of myeloid differentiation factor 88 (MyD88) and interleukin-1β (IL-1β), while significantly increased the sucrase activity and villus height/crypt depth ratio in ileum (P<0.05). Besides, dietary supplemented with MA-EO complex significantly up-regulated the mRNA relative expression level of claudin-5 in ileal mucosa (P<0.05); dietary supplemented with MA-OA complex significantly reduced the relative amount of Salmonella in ileum (P<0.05), and significantly down-regulated the mRNA relative expression level of nuclear factor kappa B p65 (NF-κB p65) in ileal mucosa (P<0.05), while significantly enhanced the alkaline phosphatase activity in ileum and villus height/crypt depth ratio in jejunum (P<0.05). In conclusion, dietary supplemented with MA-OA complex or MA-EO complex can improve intestinal mucosal barrier function, which contributes to the health of the intestine in laying hens.

Cite this article

CHEN Jifa , ZHANG Jiaxin . Effects of Mycotoxin Adsorbent-Organic Acid Complex and Mycotoxin Adsorbent-Essential Oil Complex on Intestinal Mucosal Barrier Function of Laying Hens[J]. Chinese Journal of Animal Nutrition, 2022 , 34(11) : 6994 -7001 . DOI: 10.3969/j.issn.1006-267x.2022.11.020

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