Effects of Different Forms of Zinc Oxide on Growth Performance, Serum Biochemical Indexes and Antioxidant Capacity of Meat Rabbits

CAI Jingyi; WU Shuang; KUANG Yinggu; LIU Guangmang; ZHAO Hua; JIA Gang; TIAN Gang

doi:10.3969/j.issn.1006-267x.2022.11.051

2022 , Vol. 34 >Issue 11: 7342 - 7349

DOI: https://doi.org/10.3969/j.issn.1006-267x.2022.11.051

RESEARCH PAPER

Effects of Different Forms of Zinc Oxide on Growth Performance, Serum Biochemical Indexes and Antioxidant Capacity of Meat Rabbits

CAI Jingyi ,
WU Shuang ,
KUANG Yinggu ,
LIU Guangmang ,
ZHAO Hua ,
JIA Gang ,
TIAN Gang

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1. Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China;
2. Animal Disease-Resistance Nutrition, Key Laboratory of Sichuan Province, Chengdu 611130, China;
3. Fujiang Syno Biotech Co., Ltd., Fuzhou 350700, China

Received date: 2022-05-11

Online published: 2022-11-14

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Abstract

The aim of this study is to investigate the effects of different forms of zinc oxide on growth performance, serum biochemical indexes and antioxidant capacity of meat rabbits. A total of 162 healthy New Zealand white rabbits[(689.74±34.58) g] aged 35 days were randomly divided into three groups with 27 replicates in each group and 2 rabbits in each replicate. Rabbits were fed a basal diet supplemented with feed grade zinc oxide (F-ZnO), nano zinc oxide (N-ZnO) or coated zinc oxide (C-ZnO), at doses of 120 mg/kg (calculated as zinc). The experiment lasted for 42 days and was divided into two stages as early stage (days 1 to 21) and late stage (days 22 to 42). The results showed as follows:1) compared with F-ZnO, N-ZnO and C-ZnO supplementation had no significant effects on the average daily feed intake in early, late and whole period (P>0.05), but significantly increased the average daily gain (P<0.05), and significantly decreased the ratio of feed to gain (P<0.05) at late stage of the experiment. Dietary C-ZnO supplementation significantly decreased the feed to gain ratio during the whole period (P<0.05). Dietary N-ZnO and C-ZnO could decrease diarrhea rate and health risk index of meat rabbits. 2) Compared with F-ZnO, dietary N-ZnO and C-ZnO had no significant effects on the contents of total protein, albumin, globulin, glucose, total cholesterol and triglyceride and the activities of aspartate aminotransferase and alanine aminotransferase in serum of meat rabbits (P>0.05); serum zinc and copper contents were not significantly affected (P>0.05), but serum iron content was significantly increased in the early stage of the experiment (P<0.05), and decreased in the late stage of the experiment (P<0.05). Dietary N-ZnO supplementation significantly increased serum alkaline phosphatase activity at day 42 of the experiment (P<0.05). 3) Compared with F-ZnO, C-ZnO supplementation significantly increased serum glutathione peroxidase (GSH-Px) activity at day 21 of the experiment (P<0.05). Dietary N-ZnO and C-ZnO significantly decreased liver malondialdehyde (MDA) content at day 42 of the experiment (P<0.05). In conclusion, dietary supplemented with N-ZnO and C-ZnO can improve the activity of serum antioxidant enzymes, reduce liver oxidative stress, reduce the health risk and improve growth performance of meat rabbits; and C-ZnO has a better effect than N-ZnO.

Key words： zinc oxide; meat rabbits; growth performance; serum biochemical indexes; antioxidative capacity

Cite this article

CAI Jingyi , WU Shuang , KUANG Yinggu , LIU Guangmang , ZHAO Hua , JIA Gang , TIAN Gang . Effects of Different Forms of Zinc Oxide on Growth Performance, Serum Biochemical Indexes and Antioxidant Capacity of Meat Rabbits[J]. Chinese Journal of Animal Nutrition, 2022 , 34(11) : 7342 -7349 . DOI: 10.3969/j.issn.1006-267x.2022.11.051

References

[1] HAHN J D, BAKER D H.Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc[J].Journal of Animal Science, 1993, 71(11):3020-3024.

[2] WANG C, ZHANG L G, YING Z X, et al.Effects of dietary zinc oxide nanoparticles on growth, diarrhea, mineral deposition, intestinal morphology, and barrier of weaned piglets[J].Biological Trace Element Research, 2018, 185(2):364-374.

[3] 魏可健.纳米氧化锌对断奶仔猪生长性能、血液生化指标及结肠微生物的影响[D].硕士学位论文.广州:华南农业大学, 2018. WEI K J.Effects of nano zinc oxide on growth performance, serum biochemical indices and microbial number in colon of weaned piglets[D].Master's Thesis.Guangzhou:South China Agricultural University, 2018.(in Chinese)
[4] 王东, 郭亮, 邓露芳, 等.纳米氧化锌对保育前期仔猪生长性能的影响[J].养猪, 2022(1):25-27. WANG D, GUO L, DENG L F, et al.Effect of nano zinc oxide on growth performance of nursery piglets in the starter phase[J].Swine Production, 2022(1):25-27.(in Chinese)
[5] RADI A M, ABDEL AZEEM N M, EL-NAHASS E S.Comparative effects of zinc oxide and zinc oxide nanoparticle as feed additives on growth, feed choice test, tissue residues, and histopathological changes in broiler chickens[J].Environmental Science and Pollution Research International, 2021, 28(5):5158-5167.

[6] KHAJEH BAMI M, AFSHARMANESH M, SALARMOINI M, et al.Effect of zinc oxide nanoparticles and Bacillus coagulans as probiotic on growth, histomorphology of intestine, and immune parameters in broiler chickens[J].Comparative Clinical Pathology, 2018, 27(2):399-406.

[7] 王超.包膜氧化锌促仔猪生长效果及机理研究[D].博士学位论文.杭州:浙江大学, 2013. WANG C.Research on beneficial effect of capsulated zinc oxide on growth in weaned piglets and its mechanism[D].Ph.D.Thesis.Hangzhou:Zhejiang University, 2013.(in Chinese)
[8] SHEN J H, CHEN Y, WANG Z S, et al.Coated zinc oxide improves intestinal immunity function and regulates microbiota composition in weaned piglets[J].The British Journal of Nutrition, 2014, 111(12):2123-2134.

[9] DE BLAS C, WISEMAN J.Nutrition of the rabbit[M].2nd ed.Wallingford:CABI, 2010.
[10] 李文.不同锌源及水平对母猪和仔猪生产性能和抗氧化性能的影响[D].硕士学位论文.泰安:山东农业大学, 2019. LI W.Effects of different zinc sources and levels on the production performance and antioxidant abilities of sows and piglets[D].Master's Thesis.Tai'an:Shandong Agricultural University, 2019.(in Chinese)
[11] AKHAVAN-SALAMAT H, GHASEMI H A.Effect of different sources and contents of zinc on growth performance, carcass characteristics, humoral immunity and antioxidant status of broiler chickens exposed to high environmental temperatures[J].Livestock Science, 2019, 223:76-83.
[12] 徐君, 蔡景义, 师筑俊.日粮添加氧化锌对肉兔生长性能和血清生化指标的影响[J].黑龙江畜牧兽医, 2021(14):137-139, 147. XU J, CAI J Y, SHI Z J.Effects of dietary zinc oxide supplementation on growth performance and serum biochemical indexes of table rabbits[J].Heilongjiang Animal Science and Veterinary Medicine, 2021(14):137-139, 147.(in Chinese)
[13] HASSAN F A M, KISHAWY A T Y, MOUSTAFA A, et al.Growth performance, tissue precipitation, metallothionein and cytokine transcript expression and economics in response to different dietary zinc sources in growing rabbits[J].Journal of Animal Physiology and Animal Nutrition, 2021, 105(5):965-974.

[14] RICHARDS M P, POCH S M, MCMURTRY J P.Characterization of turkey and chicken ghrelin genes, and regulation of ghrelin and ghrelin receptor mRNA levels in broiler chickens[J].General and Comparative Endocrinology, 2006, 145(3):298-310.

[15] RAMIAH S K, ATTA AWAD E, HEMLY N I M, et al.Effects of zinc oxide nanoparticles on regulatory appetite and heat stress protein genes in broiler chickens subjected to heat stress[J].Journal of Animal Science, 2020, 98(10):skaa300.
[16] ZHAO C Y, TAN S X, XIAO X Y, et al.Effects of dietary zinc oxide nanoparticles on growth performance and antioxidative status in broilers[J].Biological Trace Element Research, 2014, 160(3):361-367.

[17] 朱宇旌, 苏欣, 李方方, 等.包被氧化锌对断奶仔猪生长性能、血清生化指标及营养物质表观消化率的影响[J].动物营养学报, 2015, 27(6):1779-1786. ZHU Y J, SU X, LI F F, et al.Effects of coated ZnO on growth performance, serum biochemical indices and nutrient apparent digestibility of weaner piglets[J].Chinese Journal of Animal Nutrition, 2015, 27(6):1779-1786.(in Chinese)
[18] 李芳, 游斌杰, 郑萍.高效包被氧化锌对断奶仔猪生长性能、血液生化指标及微量元素排泄量的影响[J].畜牧与饲料科学, 2021, 42(4):19-24. LI F, YOU B J, ZHENG P.Effects of dietary supplementation of high-efficient coated zinc oxide on growth performance, blood biochemical indexes and trace elements excretion in weaned piglets[J].Animal Husbandry and Feed Science, 2021, 42(4):19-24.(in Chinese)
[19] KIM J C, HANSEN C F, MULLAN B P, et al.Nutrition and pathology of weaner pigs:nutritional strategies to support barrier function in the gastrointestinal tract[J].Animal Feed Science and Technology, 2012, 173(1/2):3-16.
[20] 袁超, 李俊明, 王超, 等.包膜氧化锌对断奶仔猪血清生化指标、脂代谢及消化酶活性的影响[J].中国畜牧杂志, 2015, 51(15):33-36. YUAN C, LI J M, WANG C, et al.Effects of capsulated zinc oxide on serum biochemical indices, lipid metabolism and activity of digestive enzyme of weaning piglets[J].Chinese Journal of Animal Science, 2015, 51(15):33-36.(in Chinese)
[21] 杨远廷, 何婉晴, 黄丽婷, 等.不同锌源对蛋鸡生产性能、血清生化指标及微量元素沉积的影响[J].动物营养学报, 2022, 34(4):2393-2402. YANG Y T, HE W Q, HUANG L T, et al.Effects of different zinc sources on performance, serum biochemical indexes and microelement deposition of laying hens[J].Chinese Journal of Animal Nutrition, 2022, 34(4):2393-2402.(in Chinese)
[22] SZUBA-TRZNADE A, RZASA A, HIKAWCZUK T, et al.Effect of zinc source and level on growth performance and zinc status of weaned piglets[J].Animals, 2021, 11(7):2030.
[23] NIELSEN F, MIKKELSEN B B, NIELSEN J B, et al.Plasma malondialdehyde as biomarker for oxidative stress:reference interval and effects of life-style factors[J].Clinical Chemistry, 1997, 43(7):1209-1214.

[24] CUNNINGHAM-RUNDLES S, BOCKMAN R S, LIN A, et al.Physiological and pharmacological effects of zinc on immune response[J].Annals of the New York Academy of Sciences, 1990, 587:113-122.
[25] 王铕, 陈浩, 万蒙, 等.包被纳米氧化锌对断奶仔猪生长性能、抗氧化酶活性及血清生化和免疫指标的影响[J].中国畜牧杂志, 2020, 56(2):117-121, 126. WANG Y, CHEN H, WAN M, et al.Effects of coated nano-zinc oxide on growth performance, activity of antioxidation enzyme and serum biochemical, immune index of weaned piglets[J].Chinese Journal of Animal Science, 2020, 56(2):117-121, 126.(in Chinese)
[26] EI-KATCHA M, SOLTAN M, EIBADRY M.Effect of dietary replacement of inorganic zinc by organic or nanoparticles sources on growth performance, immune response and intestinal histopathology of broiler chicken[J].Alexandria Journal of Veterinary Sciences, 2017, 55(2):129-145.

[27] HAFEZ A, NASSEF E, FAHMY M, et al.Impact of dietary nano-zinc oxide on immune response and antioxidant defense of broiler chickens[J].Environmental Science and Pollution Research International, 2020, 27(16):19108-19114.

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