[1] REICHARDT N, DUNCAN S H, YOUNG P, et al.Phylogenetic distribution of three pathways for propionate production within the human gut microbiota[J].The ISME Journal, 2014, 8(6):1323-1335.
[2] DE VADDER F, MITHIEUX G.Gut-brain signaling in energy homeostasis:the unexpected role of microbiota-derived succinate[J].Journal of Endocrinology, 2018, 236(2):R105-R108.
[3] CONNORS J, DAWE N, VAN LIMBERGEN J.The role of succinate in the regulation of intestinal inflammation[J].Nutrients, 2018, 11(1):25.
[4] CUMMINGS J H, POMARE E W, BRANCH W J, et al.Short chain fatty acids in human large intestine, portal, hepatic and venous blood[J].Gut, 1987, 28(10):1221-1227.
[5] DE VADDER F, KOVATCHEVA-DATCHARY P, ZITOUN C, et al.Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis[J].Cell Metabolism, 2016, 24(1):151-157.
[6] 徐亚琼.琥珀酸通过GPR91调控骨骼肌有氧氧化和肌纤维类型的转变[D].硕士学位论文.广州:华南农业大学, 2017. XU Y Q.GPR91 mediates succinate regulation of skeletal muscle oxidative metabolism and muscle fiber type switch[D].Master's Thesis.Guangzhou:South China Agricultural University, 2017.(in Chinese)
[7] ZAPPATERRA M, DESERTI M, MAZZA R, et al.A gene and protein expression study on four porcine genes related to intramuscular fat deposition[J].Meat Science, 2016, 121:27-32.
[8] OKEUDO N J, MOSS B W.Interrelationships amongst carcass and meat quality characteristics of sheep[J].Meat Science, 2005, 69(1):1-8.
[9] 邱凯.胞内钙离子平衡与骨骼肌前体细胞成肌成脂分化的关系研究[D].博士学位论文.北京:中国农业大学, 2018. QIU K.Studies on the relationship between intracellular calcium ion homeostasis and the myogenic or adipogenic differentiation of precursors in skeletal muscle[D].Ph.D.Thesis.Beijing:China Agricultural University, 2018.(in Chinese)
[10] 梁冰清.琥珀酸对肌肉生长和猪肉品质的影响[D].硕士学位论文.广州:华南农业大学, 2018. LIANG B Q.Effects of succinate on muscle growth and pork quality[D].Master's Thesis.Guangzhou:South China Agricultural University, 2018.(in Chinese)
[11] ESPINOSA A, LEIVA A, PEÑA M, et al.Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase;ROS-elicited Ca
2+ stimulates ERK, CREB, early genes[J].Journal of Cellular Physiology, 2006, 209(2):379-388.
[12] MAY C, WEIGL L, KAREL A, et al.Extracellular ATP activates ERK1/ERK2 via a metabotropic P2Y1 receptor in a Ca
2+ independent manner in differentiated human skeletal muscle cells[J].Biochemical Pharmacology, 2006, 71(10):1497-1509.
[13] WANG T, XU Y Q, YUAN Y X, et al.Succinate induces skeletal muscle fiber remodeling via SUCNR1 signaling[J].EMBO Reports, 2021, 22(6):e53027.
[14] WANG K, LIAO M F, ZHOU N, et al.
Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids[J].Cell Reports, 2019, 26(1):222-235.e5.
[15] KOVATCHEVA-DATCHARY P, NILSSON A, AKRAMI R, et al.Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of
Prevotella[J].Cell Metabolism, 2015, 22(6):971-982.
[16] PURUSHE J, FOUTS D E, MORRISON M, et al.Comparative genome analysis of
Prevotella ruminicola and
Prevotella bryantii:insights into their environmental niche[J].Microbial Ecology, 2010, 60(4):721-729.
[17] 鲁程瑶.饲源性琥珀酸钠影响鱼类糖稳态及营养代谢的研究[D].硕士学位论文.北京:中国农业科学院, 2018. LU C Y.Effects of dietary sodium succinate on glucose homeostasis and nutritional metabolism of fish[D].Master's Thesis.Beijing:Chinese Academy of Agricultural Sciences, 2018.(in Chinese)
[18] 曾严, 危当恒, 曾高峰.琥珀酸与动脉粥样硬化的研究进展[J].中国动脉硬化杂志, 2022, 30(1):83-87. ZENG Y, WEI D H, ZENG G F.Research progress of succinate and atherosclerosis[J].Chinese Journal of Arteriosclerosis, 2022, 30(1):83-87.(in Chinese)
[19] MACIAS-CEJA D C, ORTIZ-MASIÁ D, SALVADOR P, et al.Succinate receptor mediates intestinal inflammation and fibrosis[J].Mucosal Immunology, 2019, 12(1):178-187.
[20] LEI W W, REN W W, OHMOTO M, et al.Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine[J].Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(21):5552-5557.
[21] NADJSOMBATI M S, MCGINTY J W, LYONS-COHEN M R, et al.Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit[J].Immunity, 2018, 49(1):33-41.e7.
[22] 陈蓉, 曹玉敏, 郁鑫鑫, 等.琥珀酸在免疫代谢中的研究进展[J].临床医药文献电子杂志, 2018, 5(42):194-195. CHEN R, CAO Y M, YU X X, et al.The research progress of succinate in immunometabolism[J].Journal of Clinical Medical Literature (Electronic Edition), 2018, 5(42):194-195.(in Chinese)
[23] TANNAHILL G M, CURTIS A M, ADAMIK J, et al.Succinate is an inflammatory signal that induces IL-1β through HIF-1α[J].Nature, 2013, 496(7444):238-242.
[24] TANNAHILL G M, O'NEILL L A J.The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3[J].FEBS Letters, 2011, 585(11):1568-1572.
[25] DENKO N C.Hypoxia, HIF1 and glucose metabolism in the solid tumour[J].Nature Reviews Cancer, 2008, 8(9):705-713.
[26] CHU H X, JONES N M.Changes in hypoxia-inducible factor-1 (HIF-1) and regulatory prolyl hydroxylase (PHD) enzymes following hypoxic-ischemic injury in the neonatal rat[J].Neurochemical Research, 2016, 41(3):515-522.
[27] LAMY C, MANSARD C, BLONDEL L, et al.Quantification of succinic acid levels, linked to succinate dehydrogenase (SDH) dysfunctions, by an automated and fully validated liquid chromatography tandem mass spectrometry method suitable for multi-matrix applications[J].Journal of Chromatography B, 2022, 1189:123085.
[28] PALMIERI E M, MENGA A, MARTÍN-PÉREZ R, et al.Pharmacologic or genetic targeting of glutamine synthetase skews macrophages toward an M1-like phenotype and inhibits tumor metastasis[J].Cell Reports, 2017, 20(7):1654-1666.
[29] NEHELA Y, KILLINY N.‘
Candidatus Liberibacter asiaticus’ and its vector,
Diaphorina citri, augment the tricarboxylic acid cycle of their host via the γ-aminobutyric acid shunt and polyamines pathway[J].Molecular Plant-Microbe Interactions, 2019, 32(4):413-427.
[30] 吕思霖.琥珀酸盐通过激活HIF-1α诱导IL-1β分泌促进炎症[J].生理科学进展, 2013, 44(6):478. LYU S L.Succinate promotes inflammation by activating HIF-1α and inducing IL-1β secretion[J].Progress in Physiological Sciences, 2013, 44(6):478.(in Chinese)
[31] COLGAN S P, TAYLOR C T.Hypoxia:an alarm signal during intestinal inflammation[J].Nature Reviews Gastroenterology & Hepatology, 2010, 7(5):281-287.
[32] 章舒蕾, 梁亚敏, 罗涔方, 等.琥珀酸通过活性氧途径诱导人脐静脉内皮细胞焦亡[J].中国动脉硬化杂志, 2021, 29(1):42-47. ZHANG S L, LIANG Y M, LUO C F, et al.Succinate induces pyroptosis of human umbilical vein endothelial cells via reactive oxygen species pathway[J].Chinese Journal of Arteriosclerosis, 2021, 29(1):42-47.(in Chinese)
[33] O'NEILL L A J, PEARCE E J.Immunometabolism governs dendritic cell and macrophage function[J].Journal of Experimental Medicine, 2016, 213(1):15-23.
[34] GUZY R D, SHARMA B, BELL E, et al.Loss of the SdhB, but not the SdhA, subunit of complex Ⅱ triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis[J].Molecular and Cellular Biology, 2008, 28(2):718-731.
[35] KIETZMANN T, GÖRLACH A.Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression[J].Seminars in Cell & Developmental Biology, 2005, 16(4/5):474-486.
[36] 汪涛, 孙新, 李玲.琥珀酸在M1型巨噬细胞中积累及其信号传递研究进展[J].中南药学, 2020, 18(11):1858-1862. WANG T, SUN X, LI L.Research progress of succinic acid accumulation and signaling in M1 macrophages[J].Central South Pharmacy, 2020, 18(11):1858-1862.(in Chinese)
[37] FERNÁNDEZ-VELEDO S, CEPERUELO-MALLAFRÉ V, VENDRELL J.Rethinking succinate:an unexpected hormone-like metabolite in energy homeostasis[J].Trends in Endocrinology and Metabolism, 2021, 32(9):680-692.
[38] DIEHL J, GRIES B, PFEIL U, et al.Expression and localization of GPR91 and GPR99 in murine organs[J].Cell and Tissue Research, 2016, 364(2):245-262.
[39] HE W H, MIAO F J P, LIN D C H, et al.Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors[J].Nature, 2004, 429(6988):188-193.
[40] GILISSEN J, JOURET F, PIROTTE B, et al.Insight into SUCNR1 (GPR91) structure and function[J].Pharmacology & Therapeutics, 2016, 159:56-65.
[41] PERUZZOTTI-JAMETTI L, BERNSTOCK J D, VICARIO N, et al.Macrophage-derived extracellular succinate licenses neural stem cells to suppress chronic neuroinflammation[J].Cell Stem Cell, 2018, 22(3):355-368.e13.
[42] LI L, DONG Y L, LIU T, et al.Increased succinate receptor GPR91 involved in the pathogenesis of Mooren's ulcer[J].International Journal of Ophthalmology, 2018, 11(11):1733-1740.
[43] LITTLEWOOD-EVANS A, SARRET S, APFEL V, et al.GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis[J].Journal of Experimental Medicine, 2016, 213(9):1655-1662.
[44] SARAIVA A L, VERAS F P, PERES R S, et al.Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes[J].The FASEB Journal, 2018, 32(12):6550-6558.
[45] RUBIC T, LAMETSCHWANDTNER G, JOST S, et al.Triggering the succinate receptor GPR91 on dendritic cells enhances immunity[J].Nature Immunology, 2008, 9(11):1261-1269.
[46] SALLUSTO F, SCHAERLI P, LOETSCHER P, et al.Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation[J].European Journal of Immunology, 1998, 28(9):2760-2769.
[47] LI X, MAO M Y, ZHANG Y N, et al.Succinate modulates intestinal barrier function and inflammation response in pigs[J].Biomolecules, 2019, 9(9):486.
[48] OWYANG A M, ZAPH C, WILSON E H, et al.Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract[J].Journal of Experimental Medicine, 2006, 203(4):843-849.
[49] GERBE F, SIDOT E, SMYTH D J, et al.Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites[J].Nature, 2016, 529(7585):226-230.
[50] SARAIVA M, O'GARRA A.The regulation of IL-10 production by immune cells[J].Nature Reviews Immunology, 2010, 10(3):170-181.
[51] FUSUNYAN R D, QUINN J J, OHNO Y, et al.Butyrate enhances interleukin (IL)-8 secretion by intestinal epithelial cells in response to IL-1β and lipopolysaccharide[J].Pediatric Research, 1998, 43(1):84-90.
[52] KLINGSPOR S, BONDZIO A, MARTENS H, et al.
Enterococcus faecium NCIMB 10415 modulates epithelial integrity, heat shock protein, and proinflammatory cytokine response in intestinal cells[J].Mediators of Inflammation, 2015, 2015:304149.
[53] PARK H, LI Z X, YANG X X O, et al.A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17[J].Nature Immunology, 2005, 6(11):1133-1141.
[54] KUHN K A, MANIERI N A, LIU T C, et al.IL-6 stimulates intestinal epithelial proliferation and repair after injury[J].PLoS One, 2014, 9(12):e114195.
[55] MACIA L, TAN J, VIEIRA A T, et al.Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome[J].Nature Communications, 2015, 6(1):6734.
[56] ZHANG Y N, YU K F, CHEN H Z, et al.Caecal infusion of the short-chain fatty acid propionate affects the microbiota and expression of inflammatory cytokines in the colon in a fistula pig model[J].Microbial Biotechnology, 2018, 11(5):859-868.
[57] DIAO H, JIAO A R, YU B, et al.Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets[J].Genes & Nutrition, 2019, 14:4.
[58] YAN H, AJUWON K M.Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway[J].PLoS One, 2017, 12(6):e0179586.
[59] PICHE T, BARBARA G, AUBERT P, et al.Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome:involvement of soluble mediators[J].Gut, 2009, 58(2):196-201.
