RESEARCH PAPER

Effects of Compound Acidifiers on Growth Performance, Immune and Antioxidant Function and Jejunum Morphology of Ira Rabbits

  • YANG Guofeng ,
  • DI Bin ,
  • HE Jiayi ,
  • WANG Changkang ,
  • GAN Qianfu ,
  • GAO Yuyun
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  • College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, China

Received date: 2022-05-19

  Online published: 2022-12-15

Abstract

This experiment was conducted to investigate the effects of compound acidifiers on growth performance, immune and antioxidant function and jejunum morphology of Ila rabbits. A total of 192 healthy (35±2) day-old male Ila rabbits with similar body weight were randomly divided into 4 groups with 6 replicates per group and 8 rabbits per replicate. Rabbits in the control group were fed a basal diet, those in the antibiotic group were fed the basal diet supplemented with 60 mg/kg salinomycin, and those in the experimental groups were fed the basal diet supplemented with 0.1% (experimental group Ⅰ) and 0.2% compound acidifiers (experimental group Ⅱ), respectively. The active components in compound acidifiers were formic acid and propionic acid. The experiment lasted for 28 days. The results showed as follows:1) compared with the control group, the average daily feed intake of Ila rabbits in experimental group Ⅰ was significantly increased (P<0.05), and the average daily gain had an increasing trend (P=0.076); the diarrhea rate in the antibiotic group and experimental group Ⅰ was significantly decreased (P<0.05). There were no significant differences in feed to gain ratio among all groups (P>0.05). 2) Compared with the control group, diets supplemented with different levels of compound acidifiers had no significant effects on immune organ indices of Ila rabbits (P>0.05); the serum interleukin-6 content in the antibiotic group and experimental group Ⅰ was significantly decreased (P<0.05), and the serum tumor necrosis factor-α content in the antibiotic group, experimental group Ⅰ and experimental group Ⅱ was significantly decreased (P<0.05). There were no significant differences in serum contents of interleukin-1β and interleukin-10 among all groups (P>0.05). 3) Compared with the control group, the malondialdehyde content in liver of Ila rabbits in experimental group Ⅰ had a tendency to decrease (P=0.084). There were no significant differences in the other liver antioxidant indices among all groups (P>0.05). 4) Compared with the control group, the villus height and villus height to crypt depth ratio in jejunum of Ila rabbits in the antibiotic group, experimental group Ⅰ and experimental group Ⅱ were significantly increased (P<0.05). There was no significant difference in the crypt depth in jejunum among all groups (P>0.05). In conclusion, dietary compound acidifiers can enhance the immune function, improve jejunum morphology, increase the average daily feed intake, and reduce the diarrhea rate of Ila rabbits. Dietary 0.1% compound acidifiers have the best effect, which is similar to the effects of adding antibiotics, and has a good potential to replace antibiotics.

Cite this article

YANG Guofeng , DI Bin , HE Jiayi , WANG Changkang , GAN Qianfu , GAO Yuyun . Effects of Compound Acidifiers on Growth Performance, Immune and Antioxidant Function and Jejunum Morphology of Ira Rabbits[J]. Chinese Journal of Animal Nutrition, 2022 , 34(12) : 8029 -8037 . DOI: 10.3969/j.issn.1006-267x.2022.12.050

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