Chinese Journal of Animal Nutrition >

2026 , Vol. 38 >Issue 5: 3608 - 3617

DOI: https://doi.org/10.12418/CJAN2026.288

RESEARCH PAPER

Effects of Capillarisin on Growth Performance, Serum Inflammatory Indices and Cecal Microflora KEGG Pathways of Ira Meat Rabbits

  • WANG Guoyan ,
  • YANG Lihua ,
  • FAN Aifang ,
  • LIU Huadong ,
  • LI Tingting ,
  • TANG Juan ,
  • CAO Liang , *
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  • College of Animal Sciences, Shanxi Agricultural University, Taiyuan 030032, China
*associate professor, E-mail:

Received date: 2025-10-21

  Online published: 2026-05-14

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Abstract

This experiment aimed to investigate the effects of dietary capillarisin on growth performance, serum inflammatory indices and cecal microflora KEGG pathways of Ira meat rabbits. Two hundred and forty 35-day-old weaned Ira meat rabbits with similar body weight were randomly assigned to 4 groups with 60 replicates per group and 1 rabbit per replicate. The control group was fed a basal diet, and the experimental groups were fed the basal diets supplemented with 0.001% (test group Ⅰ), 0.002% (test group Ⅱ), and 0.003% (test group Ⅲ) capillarisin, respectively. The experiment consisted of a 7-day adaptation period followed by a 21-day formal trial period. The results showed as follows: 1) compared with the control group, the feed to gain ratio of test group Ⅱ was significantly decreased (P<0.05). 2) Compared with the control group, the contents of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and nuclear factor-κB (NF-κB) in serum of test group Ⅰ, test group Ⅱ and test group Ⅲ were significantly decreased (P<0.05); furthermore, the contents of IL-6, TNF-α and NF-κB in serum of test group Ⅱ were significantly lower than those of test group Ⅰ and test group Ⅲ (P<0.05). 3) Compared with the control group, at the phylum level, the cecal TM7 relative abundance of test group Ⅱ was significantly decreased (P<0.05), and the Cyanobacteria relative abundance was significantly increased (P<0.05). The linear discriminant analysis effect size (LEfSe) method was used to analyze the differences of cecal microbial marker species, compared with the control group, the marker species with higher relative abundance of test group Ⅱ were Mogibacteriaceae, Ruminococcus, Thermotogae, Kosmotoga, Thermotogales and Thermotogaceae; compared with the test group Ⅰ, the marker species with higher relative abundance of test group Ⅱ were Thermotogae, Thermotogales, Thermotogaceae, Kosmotoga and Oscillospira; compared with the test group Ⅲ, the marker species with higher relative abundance of test group Ⅱ were chloroplast, Streptophyta, Faecalibacterium, Cucumis and mitochondria. 4) Compared with the control group, the enrichment levels of SUCSYN-PWY and PWY-7347 pathways of test group Ⅱ were significantly up-regulated (P<0.05); compared with the test group Ⅲ, the enrichment level of CHLOROPHYLL-SYN pathway of test group Ⅱ was significantly up-regulated (P<0.05). In summary, dietary supplemented with 0.002% capillarisin can reduce the feed to gain ratio and serum proinflammatory factor contents of meat rabbits, improve the relative abundance of beneficial bacteria in intestine, enrichment level of CHLOROPHYLL-SYN pathway and intestinal environment, and enhance the body immunity.

Key words： capillarisin; meat rabbits; nuclear factor-κB; KEGG pathways

Cite this article

WANG Guoyan , YANG Lihua , FAN Aifang , LIU Huadong , LI Tingting , TANG Juan , CAO Liang . Effects of Capillarisin on Growth Performance, Serum Inflammatory Indices and Cecal Microflora KEGG Pathways of Ira Meat Rabbits[J]. Chinese Journal of Animal Nutrition, 2026 , 38(5) : 3608 -3617 . DOI: 10.12418/CJAN2026.288

《神农本草经》记载,茵陈(Artemisia scoparia)味微苦,平,性微寒,入脾胃、膀胱经,有清利湿热、利胆退黄之功效[1-2]。研究发现,茵陈具有抗炎抑菌、抗氧化、提高免疫力等作用[3]。朱正望等[4]研究表明,茵陈对核因子-κB(NF-κB)有调控作用;杨凯等[5]研究表明,茵陈蒿可改善绒山羊血清免疫指标,促进瘤胃发酵[5]。茵陈黄酮作为其主要有效成分之一,对机体炎症指标有改善作用。刘扬等[6]研究表明,茵陈黄酮可通过对白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、NF-κB的调节来改善机体健康状况;史娟等[7]研究表明,茵陈黄酮具有抗氧化性;倪斌等[8]研究表明,茵陈黄酮具有改善小鼠肝脏功能的作用;Wang等[9]研究表明,茵陈黄酮具有抗氧化性及保肝护肝等作用[9];啜亚南等[10]研究表明,茵陈水提物可改善小鼠肝脏受损状况,降低炎性因子基因表达量。目前,茵陈在畜牧业中的应用研究多围绕在其对动物机体免疫功能等的影响,对肠道微生物的影响研究较少。此外,茵陈黄酮在商品肉兔养殖中的应用及其对肠道微生物KEGG通路的影响鲜有报道。因此,本试验在饲粮中添加不同比例的茵陈黄酮,研究其对肉兔生长性能、血清炎症指标及盲肠微生物KEGG通路的影响,为茵陈黄酮在商品肉兔养殖中的科学应用提供理论依据。

1 材料与方法

1.1 试验设计和饲养管理

动物试验经山西农业大学实验动物伦理委员会审批,批准编号为SXAU-EAW-2025R.DW.006027319。
选择240只体重相近的35日龄断奶伊拉商品肉兔,随机分为4个组,每组60个重复,每个重复1只兔。对照组饲喂基础饲粮,试验组分别在基础饲粮中添加0.001%(试验Ⅰ组)、0.002%(试验Ⅱ组)、0.003%(试验Ⅲ组)的茵陈黄酮(纯度>95%)。预试期7 d,正试期21 d。参照NY/T 4049—2021[11]配制基础饲粮,其组成及营养水平见表1。在预混料中添加不同比例的茵陈黄酮后制成试验饲粮,各饲粮均制成直径为3.5 mm的颗粒料。试验兔均采用单笼饲养,每日饲喂时间为07:30和16:30,自由采食和饮水。
表1 基础饲粮组成及营养水平(风干基础)

Table 1 Composition and nutrient levels of the basal diet (air-dry basis)%

项目 Items 含量 Content
原料 Ingredients
玉米 Corn 18.00
麸皮 Wheat bran 24.00
豆粕 Soybean meal 15.00
花生秧 Peanut vine 23.00
花生壳 Peanut hull 18.00
豆油 Soybean oil 0.40
食盐 NaCl 0.50
预混料 Premix1) 1.10
合计 Total 100.00
营养水平 Nutrient levels2)
消化能 DE/(MJ/kg) 9.17
粗蛋白质 CP 15.49
粗纤维 CF 18.15
粗灰分 Ash 6.56
赖氨酸 Lys 0.79
蛋氨酸+胱氨酸 Met+Cys 0.56
钙 Ca 0.86
总磷 TP 0.45

1)预混料为每千克饲粮提供 The premix provided the following per kg of the diet:VA 8 000 IU,VD3 960 IU,VE 41 mg,赖氨酸 Lys 2.2 g,蛋氨酸 Met 1.1 g,Cu (as copper sulfate) 10 mg,Fe (as ferrous sulfate) 80 mg,Mn (as manganese sulfate) 60 mg,Zn (as zinc sulfate) 50 mg,CaCO3 3 500 mg。

2)消化能为计算值,其余为实测值。DE was a calculate value, while the others were measured values.

1.2 样品采集及指标测定

1.2.1 饲粮营养成分

饲粮粗蛋白质、粗纤维、粗灰分、氨基酸、钙、总磷含量分别参照GB/T 6432—2018、GB/T 6434—2022、GB/T 6438—2007、GB/T 18246—2019、GB/T 13885—2017、GB/T 6437—2018的方法进行测定。消化能根据NY/T 4049—2021[11]中各原料的消化能相关数据计算得到。

1.2.2 生长性能

正试期开始时,在07:00对试验兔进行称重记录,记为初始体重(IBW);正试期结束第2天07:00进行称重记录,记为末期体重(FBW)。记录正试期每只试验兔的采食量,计算平均日采食量(ADFI)、平均日增重(ADG)和料重比(F/G)。记录正试期试验兔的腹泻和死亡情况,计算腹泻率和死亡率,计算公式如下:

腹泻率(%)=[(腹泻只数×腹泻天数)/

(样本总数×试验天数)]×100;

死亡率(%)=(死亡只数/样本总数)×100。

1.2.3 血清炎症指标

正试期结束后,每组参照性别对称、体重相近原则,随机挑选8只试验兔,颈动脉采血约3 mL,置于5 mL的一次性采血管中,在4 ℃环境中静置2 h后,将血清分装在1.5 mL的EP管中,置于-80 ℃冰箱,备用。采用江苏酶免实业有限公司生产的酶联免疫吸附测定(ELISA)试剂盒,对血清IL-6、TNF-α和NF-κB含量进行测定。

1.2.4 肠道微生物KEGG通路

正试期结束后,次日屠宰,每组参照性别对称、体重相近原则,随机挑选6只试验兔进行屠宰,分别采集盲肠内容物。采集的新鲜盲肠内容物,置于5 mL冻存管,液氮速冻15 min后,-80 ℃冰箱保存备用。在Illumina Hi-Seq平台上,对盲肠内容物微生物的有效序列进行多样性分析;使用MetagenomeSeq的方法对获得的KEGG通路丰度进行组间差异分析。

1.3 数据分析和统计

运用SPSS 26.0统计软件对试验数据进行单因素方差分析和Duncan氏法多重比较,结果用平均值±标准误表示,P<0.05为差异显著。

2 结果与分析

2.1 茵陈黄酮对肉兔生长性能的影响

由表2可知,与对照组相比,试验Ⅱ组的料重比显著降低(P<0.05)。各组之间末期体重、平均日采食量、平均日增重、腹泻率和死亡率均无显著差异(P>0.05)。
表2 茵陈黄酮对肉兔生长性能的影响

Table 2 Effects of capillarisin on growth performance of meat rabbits

项目
Items		 对照组
Control group		 试验Ⅰ组
Test group Ⅰ		 试验Ⅱ组
Test group Ⅱ		 试验Ⅲ组
Test group Ⅲ
初始体重 IBW/g 1 347.48±72.39 1 345±45.79 1 341.83±48.43 1 343.30±53.92
末期体重 FBW/g 2 536.00±142.00 2 562.43±122.55 2 583.13±98.89 2 540.93±153.22
平均日采食量 ADFI/g 139.70±9.77 138.33±6.99 139.00±7.56 139.29±9.00
平均日增重 ADG/g 42.45±3.41 43.48±4.01 44.33±3.07 42.77±4.75
料重比 F/G 3.30±0.17a 3.20±0.19ab 3.14±0.17b 3.28±0.26a
腹泻率 Diarrhea rate/% 5.00 3.33 0 0
死亡率 Mortality/% 3.33 3.33 0 0

同行数据肩标不同小写字母表示差异显著(P<0.05),相同或无字母表示差异不显著(P>0.05)。下表同。

In the same row, values with different small letter superscripts mean significant difference (P<0.05), while with the same or no letter superscripts mean no significant difference (P>0.05). The same as below.

2.2 茵陈黄酮对肉兔血清炎症指标的影响

由表3可知,与对照组相比,试验Ⅰ组、试验Ⅱ组和试验Ⅲ组的血清IL-6、TNF-α和NF-κB含量均显著降低(P<0.05);此外,试验Ⅱ组的血清IL-6、TNF-α和NF-κB含量显著低于试验Ⅰ组和试验Ⅲ组(P<0.05)。
表3 茵陈黄酮对肉兔血清炎症指标的影响

Table 3 Effects of capillarisin on serum inflammatory indices of meat rabbitspg/mL

项目
Items		 对照组
Control group		 试验Ⅰ组
Test group Ⅰ		 试验Ⅱ组
Test group Ⅱ		 试验Ⅲ组
Test group Ⅲ
白细胞介素-6 IL-6 58.14±4.51a 34.97±4.48c 27.16±4.86d 40.55±4.70b
肿瘤坏死因子-α TNF-α 4 384.26±261.47a 2 600.33±299.33c 2 137.64±298.70d 3 155.06±270.17b
核因子-κB NF-κB 1 821.90±100.80a 932.41±177.38c 643.70±154.19d 1 153.08±138.24b

2.3 茵陈黄酮对肉兔盲肠微生物的影响

2.3.1 各样本可行性分析

由图1可知,丰度等级曲线可以反映微生物群落中高丰度和稀有操作分类单元(OTU)的数量,折线越平缓,表明微生物群落间的丰度差异越小,群落组成的均匀度越高。由图2可知,应力(Stress)值小于0.2(Stress=0.125),表明非度量多维尺度(NMDS)分析比较可靠,图中各组重叠区域较大,表明各组微生物群落组成相似。
图1 丰度等级曲线

Fig.1 Rank-abundance curve

图2 UniFrac非度量多维尺度分析图

Fig.2 NMDS analysis diagram of UniFrac

2.3.2 盲肠微生物多样性分析

由表4可知,各组之间盲肠微生物Alpha多样性指数均无显著差异(P>0.05)。
表4 盲肠微生物Alpha多样性指数

Table 4 Alpha diversity indices of cecal microflora

项目
Items		 对照组
Control group		 试验Ⅰ组
Test group Ⅰ		 试验Ⅱ组
Test group Ⅱ		 试验Ⅲ组
Test group Ⅲ
Chao1指数 Chao1 index 1 792.54±236.42 1 789.92±238.52 1 861.92±141.35 1 818.35±159.43
Observed_species指数
Observed_species index		 1 716.67±204.64 1 691.30±217.09 1 787.05±127.69 1 742.93±126.87
Simpson指数 Simpson index 0.98±0.01 0.99±0.00 0.99±0.00 0.99±0.01
Shannon指数 Shannon index 8.19±0.41 8.50±0.15 8.48±0.17 8.32±0.42
Pielou_e指数 Pielou_e index 0.76±0.03 0.79±0.01 0.79±0.01 0.77±0.04

2.3.3 盲肠微生物组成在门水平上的分布

由表5可知,在门水平上,与对照组相比,试验Ⅱ组的盲肠TM7相对丰度显著降低(P<0.05),蓝菌门相对丰度显著升高(P<0.05)。
表5 盲肠微生物组成在门水平上的分布

Table 5 Distribution of cecal microflora composition at phylum level%

项目
Items		 对照组
Control group		 试验Ⅰ组
Test group Ⅰ		 试验Ⅱ组
Test group Ⅱ		 试验Ⅲ组
Test group Ⅲ
厚壁菌门 Firmicutes 52.97±4.64 51.10±3.42 53.88±4.51 50.34±12.18
拟杆菌门 Bacteroidetes 25.50±5.21 24.75±4.91 21.78±3.25 20.49±6.19
变形菌门 Proteobacteria 1.95±0.75 2.83±1.11 2.39±0.73 2.35±0.86
软壁菌门 Tenericutes 2.65±3.80 0.95±0.43 0.75±0.37 3.08±3.22
疣微菌门 Verrucomicrobia 0.56±0.45 1.18±0.73 1.22±0.93 1.16±0.93
放线菌门 Actinobacteria 1.00±0.48 0.66±0.10 0.75±0.35 0.77±0.17
TM7 0.41±0.22a 0.27±0.21ab 0.14±0.06b 0.19±0.20ab
蓝菌门 Cyanobacteria 0.06±0.07b 0.07±0.07b 0.25±0.22a 0.10±0.09ab

2.3.4 盲肠微生物标志物种的差异分析

采用线性判别分析效应大小(LEfSe)方法对盲肠微生物标志物种进行差异性分析,由图3可知,与对照组相比,试验Ⅱ组相对丰度较高的标志物种为莫吉杆菌科(Mogibacteriaceae)、瘤胃球菌属(Ruminococcus)、热袍菌纲(Thermotogae)、暖袍菌属(Kosmotoga)、热袍菌目(Thermotogales)、热袍菌科(Thermotogaceae);与试验I组相比,试验Ⅱ组相对丰度较高的标志物种为热袍菌纲、热袍菌目、热袍菌科、暖袍菌属、振荡球菌属(Oscillospira);与试验Ⅲ组相比,试验Ⅱ组相对丰度较高的标志物种为叶绿体(chloroplast)、链形植物门(Streptophyta)、粪杆菌属(Faecalibacterium)、黄瓜属(Cucumis)、线粒体(mitochondria)。
图3 盲肠微生物标志物种LEfSe分析

仅列出主要标志物种 List only major marker species。Mogibacteriaceae:莫吉杆菌科;Ruminococcus:瘤胃球菌属;Thermotogae:热袍菌门;Thermotogales:热袍菌目;Thermotogaceae:热袍菌科;Kosmotoga:暖袍菌属;Oscillospira:振荡球菌属;Fusobacteriota:梭杆菌门;Fusobacteriia:梭杆菌纲;Fusobacteriales:梭杆菌目;Fusobacterium:梭杆菌属;Cetobacterium:鲸杆菌属;Gemmatimonadetes:芽单胞菌门;Chloroplast:叶绿体;Streptophyta:链形植物门;Faecalibacterium:粪杆菌属;Cucumis:黄瓜属;Mitochondria:线粒体;Cetobacterium:鲸杆菌属;Thermoactinomycetaceae:高温放线菌科;Thermoactinomyces:高温放线菌属;Faecalibacterium:粪杆菌属。

Fig.3 LEfSe analysis of cecal microflora marker species

2.3.5 盲肠微生物KEGG通路的差异分析

使用MetagenomeSeq方法对盲肠微生物KEGG通路进行两两分析,找出组间具有显著差异的KEGG通路。由表6可知,与对照组相比,试验II组富集度显著上调的KEGG通路为SUCSYN-PWY和PWY-7347(P<0.05)。
由图4可知,与试验Ⅲ组相比,试验Ⅱ组富集度显著上调的KEGG通路为CHLOROPHYLL-SYN(P<0.05);由图5可知,使该代谢通路富集度上调的菌群物种为链形植物门、毛螺菌科、克里斯滕森菌科、韦荣球菌科、红螺菌科等。
表6 盲肠微生物KEGG通路的差异分析

Table 6 Differential analysis of cecal microflora KEGG pathways

项目
Item		 通路
Pathway		 log差异倍数
logFC		 标准误SE P值
P-value
对照组vs.试验Ⅱ组
Control group vs. Test group Ⅱ		 SUCSYN-PWY
PWY-7347		 0.715
0.310		 0.228
0.103		 0.002
0.002

SUCSYN-PWY:蔗糖生物合成Ⅰ sucrose biosynthesis Ⅰ;PWY-7347:蔗糖生物合成Ⅲ sucrose biosynthesis Ⅲ。

图4 盲肠微生物KEGG通路差异(试验Ⅱ组vs.试验Ⅲ组)

CHLOROPHYLL-SYN:叶绿素苷A生物合成Ⅰ chlorophyll glycoside A biosynthesis Ⅰ。

Fig.4 KEGG pathways differences of cecal microflora (test group Ⅱ vs. test group Ⅲ)

图5 代谢通路的物种组成

Streptophyta:链形植物门;Lachnospiraceae:毛螺菌科;Bacteria:细菌;Clostridiales:梭菌目;Bacteroidales:拟杆菌目;Chrislensenellaceae:克里斯滕森菌科;Veillonellaceae:韦荣球菌科;Rhodospirillaceae:红螺菌科。

Fig.5 Species composition of metabolic pathways

3 讨论

3.1 茵陈黄酮对肉兔生长性能的影响

在动物养殖生产过程中,肉兔在育肥期的平均日增重、料重比等生长性能是衡量养殖经济效益的重要指标[12]。茵陈又称为茵陈蒿,与青蒿属于同一科。有研究报道,饲粮中添加0.25%青蒿提取物可显著提高獭兔的平均日增重,显著降低料重比[13];另有研究表明,青蒿粉替代花生秧对肉兔的平均日增重和料重比影响不显著[14],用茵陈蒿替代燕麦草对绒山羊生长性能无显著影响[5]。本研究显示,饲粮中添加0.002%茵陈黄酮可显著降低料重比,略微提升平均日增重,与上述结果有一定差异,可能是由于茵陈与青蒿来源不同以及动物物种不同。

3.2 茵陈黄酮对肉兔血清炎性指标的影响

NF-κB作为核转录因子,是炎症通路的主要信号因子,可调控相关炎性因子的分泌表达,对炎症反应的调控有重要作用[15-16],通过下调炎性因子的释放,减轻机体炎性反应。TNF-α是由巨噬细胞等分泌的一种参与早期炎症的细胞因子[17]。王娇等[18]研究表明,血清中TNF-α含量降低,在一定程度上可减少卡拉库尔羊的炎性反应。IL-6属于炎性因子,有研究表明,血清炎性因子含量升高与炎症疾病呈正相关[19]。本研究表明,饲粮中添加不同比例的茵陈黄酮均可显著降低肉兔血清NF-κB、TNF-α、IL-6含量,这表明茵陈黄酮可减轻肉兔的炎性反应,降低感染疾病的几率;添加高比例的茵陈黄酮会提升商品肉兔血清NF-κB、TNF-α、IL-6含量,这可能是因为高比例的茵陈黄酮会对机体造成一定的损伤。

3.3 茵陈黄酮对肉兔盲肠微生物KEGG通路的影响

肠道中微生物的多样性及组成与机体健康密切相关。本研究表明,饲粮中添加茵陈黄酮对商品肉兔盲肠微生物多样性无显著影响。有研究表明,TM7相对丰度升高与肠道疾病正相关。蓝菌门相对丰度在肠道中极低,其相对丰度的变化无实际意义。本研究表明,饲粮中添加0.002%茵陈黄酮可显著降低TM7相对丰度,这可能是因为茵陈黄酮可改善机体健康状态,与上述表述一致。
酸杆菌门一般在土壤中,其相对丰度与植物疾病正相关[20],在肠道中相对丰度极低;瘤胃球菌属、各类双歧杆菌、分歧杆菌对机体健康有重要意义;链形植物门在肠道中的相对丰度可反映机体对植物的消化状况,通常情况下没有直接的生理功能;莫拉菌科[21]、假单胞菌[22]多为致病菌;毛螺菌科在肠道中的相对丰度升高,可提升机体免疫力[23];梭杆菌门相对丰度升高可能诱发肠炎[24],鲸杆菌属是梭杆菌目中的一个重要属;芽单胞菌门、振荡球菌属在非疾病状态下是肠道中的友好寄生菌;热袍菌门是一类厌氧嗜热菌,可减少甲烷产生[25-26],肠道中甲烷气体富集与肠道疾病呈正相关[27],暖袍菌属是热袍菌门中一个重要的菌属;粪杆菌属[28]可代谢产生丁酸,为肠道上皮细胞的生长提供能量,改善机体生长性能,能够抑制NF-κB含量,减少炎性反应。本研究表明,试验II组的盲肠微生物标志物种为毛螺菌科、瘤胃球菌属、热袍菌纲、热袍菌目、热袍菌科、暖袍菌属、振荡球菌属、蓝细菌、链形植物门、粪杆菌属等有益微生物;试验III组的盲肠微生物标志物种多为梭杆菌门、梭杆菌纲、梭杆菌属、梭杆菌目、鲸杆菌属等有害微生物。这表明饲粮中添加茵陈黄酮可提升肠道中有益菌的相对丰度;添加0.002%茵陈黄酮可改善肠道内环境,对提升机体健康状态有促进作用;高剂量茵陈黄酮可能对机体健康有负面影响。
顾富城等[29]报道,患有膝骨关节炎的大鼠肠道菌群通路中CHLOROPHYLL-SYN通路几乎失活,治疗后该通路显著提升,变形菌门为其优势贡献物种。CHLOROPHYLL-SYN通路富集通常伴有链形植物门相对丰度升高,拟杆菌目参与机体基础代谢,克里斯滕森菌科和部分有益梭菌目对机体健康有促进作用,韦荣球菌科参与维持代谢平衡,红螺菌科是潜在益生菌。本研究中,肉兔盲肠微生物KEGG通路差异性分析显示,试验II组的CHLOROPHYLL-SYN通路富集度显著高于试验III组,引起其显著上调的菌群物种为链形植物门、毛螺菌科、梭菌目、拟杆菌目、克里斯滕森菌科、韦荣球菌科、红螺菌科等。
综上所述,饲粮中添加0.002%茵陈黄酮可能通过富集毛螺菌科、克里斯滕森菌科、韦荣球菌科、红螺菌科等有益微生物来促使CHLOROPHYLL-SYN通路活性增加,降低炎性反应,起到改善机体健康的作用。

4 结论

① 饲粮中添加0.002%茵陈黄酮可以降低肉兔血清炎性因子NF-κB、TNF-α、IL-6含量,进而降低机体炎性反应。
② 饲粮中添加0.002%茵陈黄酮可以增加肉兔CHLOROPHYLL-SYN通路活性,提升有益菌相对丰度,改善肠道微生物区系,维持肠道内环境正向平衡,促进肠道健康发展,提升机体抗感染力。

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