Aflatoxin is extremely toxic, mutagenic and carcinogenic. It poses severe threat to both livestock productivity and human health and thus brings huge worldwide economic losses on food industry, feed industry and animal husbandry each year. A safe, effective and environmental detoxification method is urgently needed for controlling this toxin because of many application defects of aflatoxin physical and chemical detoxification. Researches on aflatoxin biological detoxification in home and abroad, as well as application prospects of biological detoxification were reviewed in this paper.［Chinese Journal of Animal Nutrition, 2010，22（2）:241-245］