This study was conducted to determine the effects of feeding chrysanthemum stem-leaf on growth performance and serum antioxidant indices of growing lambs. Thirty-six weanling Hu lambs with an average body weight of （16.0±2.6） kg were randomly assigned to four groups, with three replicates per group and three lambs per replicate. The ratio of roughage to concentrate in all pelleted total mixed rations was 70∶30. Proportion of rice straw to chrysanthemum stem-leaf in roughage was 70∶0, 45∶25, 25∶45, and 0∶70 in diets Ⅰ to Ⅳ, respectively. The trial lasted for 72 days with the first 12 days for adaptation. The results showed as follows: with the feeding level of chrysanthemum stem-leaf increasing, average daily gain was increased, with a significant difference between groups Ⅰ and Ⅳ (P<0.05). With the feeding level of chrysanthemum stem-leaf increasing, serum catalase activity and total antioxidant capacity were increased, and the above two indices in groups Ⅲ and Ⅳ were significantly higher than those in group Ⅰ (P<0.05). Serum glutathione peroxidase content in group Ⅲ was significantly higher than that in other groups (P<0.05). With the feeding level of chrysanthemum stem-leaf increasing, serum malondialdehyde content was decreased, with a significant difference between groups Ⅰ and Ⅳ (P<0.05). In conclusion, chrysanthemum stem-leaf as a roughage into diets can increase antioxidant ability and promote growth of growing lambs.［Chinese Journal of Animal Nutrition, 2010，22（5）:1402-1406］