To explore the feasibility and effect of grape seed meal (GSM) as goose feed ingredient, the general nutrients of GSM were determined firstly, and then thirty 150-day-old geese were selected and randomly divided into 6 groups with 5 replicates of 1 goose in each replicate. The geese in 6 groups were fed diets with 0, 3.00%, 6.00%, 9.00%, 12.00% and 15.00% of GSM, respectively. The experimental period included 4 days of preliminary trial, 1 day of fasting and 3 days of test trial. The results showed that, the crude fiber (CF) content of GSM was 48.26%, indicating that it was a high-fiber feed. Based on the same level of general nutrients intake, the digestibilities of neutral detergent fiber (NDF), acid detergent fiber (ADF) and CF were higher in diet with 9.00% of GSM, but it showed a trend of decrease in diets with GSM from 9.00% to 15.00%. The nitrogen (N) deposition, net protein utilization and ammonia nitrogen content of diets showed a trend of increase and then decrease, and the differences were significant or extremely significant among all groups (P<0.05 or P<0.01). The highest apparent digestibilities of amino acids (except glutamic acid and aspartic acid) and total amino acid were found in diet with 9.00% of GSM, and they were significantly higher than others (P<0.05 or P<0.01). The apparent digestibilities of calcium (Ca) and phosphorus (P) showed a trend of increase and then decrease, and the highest were found in diet with 9.00% of GSM. The activity of alkaline phosphatase showed a significantly negative correlation with the digestibilities of CF and ADF (P<0.05), but an extremely significant negative correlation with the apparent digestibilities of Ca and P. The activity of glutamic pyruvic transaminase was significantly negatively related to CF (P<0.05) and was extremely significantly negatively related to the apparent digestibilities of Ca and P (P<0.01). The activity of amylase showed an extremely significant correlation with the apparent digestibilities of CF and ADF (P<0.01), a significant correlation with the apparent digestibility of NDF (P<0.05), and a significantly negative correlation with the apparent digestibility of Ca (P<0.05). It was concluded that GSM could be used as a high-fiber feed for geese and the supplementation of 9.00% GSM in diet resulted in the highest digestibilities of nutrients.［Chinese Journal of Animal Nutrition, 2010，22（2）:466-473］