Effects of Maternal Stress during Pregnancy on Offspring before and after Birth:Mechanism of Action from a Hypothalamus-Pituitary-Adrenocortical Axis

LI Liuan1,2，WU Zhanwang1，ZHAO Ruqian1*

doi:10.3969/j.issn.1006-267x.2010.05.002

2010 , Vol. 22 >Issue 05: 1138 - 1141

DOI: https://doi.org/10.3969/j.issn.1006-267x.2010.05.002

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Effects of Maternal Stress during Pregnancy on Offspring before and after Birth:Mechanism of Action from a Hypothalamus-Pituitary-Adrenocortical Axis

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(1. Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing 210095, China; 2. Department of Animal Sciences, Tianjin Agricultural University, Tianjin 300384, China)

Online published: 2010-05-20

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Abstract

Normal hypothalamus-pituitary-adrenocortical (HPA) axis activity is essential for animal physical health. Maternal stress during pregnancy programs HPA axis function, as well as the growth and development of offspring before and after birth. Fetal HPA axis is the most susceptible system responding to maternal stress. These impacts are achieved by alterations in glucocorticoid receptor and mineralocorticoid receptor expressions in hippocampus, hypothalamus and pituitary of the offspring. Adrenal cortex as an important component of HPA axis may also be a target of maternal programming, which awaits further investigation.［Chinese Journal of Animal Nutrition, 2010，22（5）:1138-1141］

Key words： maternal stress during pregnancy; offspring; HPA axis; glucocorticoid; mechanism of action

Cite this article

LI Liuan1,2，WU Zhanwang1，ZHAO Ruqian1* . Effects of Maternal Stress during Pregnancy on Offspring before and after Birth:Mechanism of Action from a Hypothalamus-Pituitary-Adrenocortical Axis[J]. Chinese Journal of Animal Nutrition, 2010 , 22(05) : 1138 -1141 . DOI: 10.3969/j.issn.1006-267x.2010.05.002

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