The experiment was conducted to study the effects of β-glucan on growth and immunity function of Schizothorax prenanti Tchang. Four hundred and thirty-two healthy Schizothorax prenanti Tchang with an average body weight of (67.97±6.99) g were randomly divided into 6 groups with 6 replicates in each group and 12 fish in each replicate. Six levels (0, 250, 500, 1 000, 2 000 and 4 000 mg/kg) of β-glucan were added in the diets of 6 groups, respectively. On the 14th, 28th, 42th, 56th day of the experiment, relative weight rate, leukocyte phagocytic percentage, erythrocyte phagocytic percentage in blood, lysozyme activity, content of complement C3, IgM in serum and SIgA in intestine were determined. The results showed that: 1) the relative weight rate in 500 mg/kg group was significantly higher (P<0.05), while 2 000 and 4 000 mg/kg groups were significantly lower than that in control group (P<0.05) on the 56th day; 2) the leukocyte phagocytic percentage, erythrocyte phagocytic percentage, content of complement C3 and IgM in 500 mg/kg group were significantly higher (P<0.05 or P<0.01) than that in control group from 14th to 56th day; the leukocyte phagocytic percentage, erythrocyte phagocytic percentage, lysozyme activity, content of complement C3 in 1 000 mg/kg group were significantly higher (P<0.05) than that in control group from 14th to 56th day and the intestinal SIgA in this group was significantly higher (P<0.05 or P<0.01) than that in control group on the 56th day; the leukocyte phagocytic percentage, erythrocytes phagocytic percentages, lysozyme activity, content of complement C3 and IgM in 2 000 mg/kg group and lysozyme activity, content of complement C3 and IgM in 4 000 mg/kg group were significantly higher (P<0.05 or P<0.01) on the 14th day while the leukocyte phagocytic percentage, content of IgM in these two groups were significantly lower (P<0.05 or P<0.01) than that in control group on the 56th day. In conclusion, 1) adding 500 mg/kg β-glucan in diet could promote the growth of Schizothorax prenanti Tchang; 2) adding 500 and 1 000 mg/kg of β-glucan in diet could enhance immunity function of Schizothorax prenanti Tchang; 3) adding 2 000 and 4 000 mg/kg of β-glucan in diet could enhance the immunity function of Schizothorax prenanti Tchang in the short time (to the 14th day), but immunity function were decreased along with the time increase(to the 56th day). Meanwhile, adding 2 000 and 4 000 mg/kg of β-glucan could inhibit the growth of Schizothorax prenanti Tchang; 4) adding 500-1 000 mg/kg β-glucan could be recommend to use in Schizothorax prenanti Tchang diet.［Chinese Journal of Animal Nutrition, ２００9，２1（5）:688-694］