This experiment was conducted to investigate the effects of  Lentinus edodes  polysaccharide (LEP) on growth performance, some serum hormone and some immune indices in piglets. One hundred and twenty pigs (Landrace × Large White) with an initial body weight of (11.34±0.62) kg were randomly allotted to four groups, each group contained five pens and each pen contained six pigs. Pigs were raised for 28 days. Group Ⅰ was fed control diet, and LEP was supplemented at 150, 300 and 450 mg/kg based on control diet for group Ⅱ, group Ⅲ and group Ⅳ, respectively. The results showed that the ADG of pigs in group Ⅱ, group Ⅲ and group Ⅳ was significantly increased (P<0.05) in the period of 0~14 d, 14~28 d and  0~28 d;ADFI was also significantly increased (P<0.05) in the period of 0~14 d and 0~28 d; but no difference was found in F/G (P>0.05). The occurrence rate of diarrhea in group Ⅱ was decreased by 23.08% compared with that in control group (P<0.05); meantime that in group Ⅲ and group Ⅳ was also decreased by 53.85% compared with that in control group (P<0.01). GH, T₃ and T₄ were increased while cortisol was decreased along with the supplement of LEP, GH and T₃ in group Ⅳ were increased (P<0.05) while cortisol in group Ⅲ was decreased (P<0.05). IgM in group Ⅱ, group Ⅲ and group Ⅳ was slightly increased, but only IgM in group Ⅳ was significantly increased (P<0.05). However, no differenceoccurred for the IgG and alexin C₄. It was concluded that supplement of 300 mg/kg LEP improved the growth performance and hormone indices in piglets.