Molecular Nutrition

Bitter Taste Receptors: Biological Characteristics, Signal Transduction Mechanism, and Effects of Bitters and Bitter Taste Inhibitors

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  • 1. College of Veterinary and Animal Science, Shenyang Agricultural University, Shenyang 110866, China;
    2. Leda(Guangzhou) Perfume Co. Ltd., Guangzhou 510530, China

Received date: 2016-09-01

  Online published: 2017-03-09

Abstract

Bitter taste receptor (TAS2Rs) is a kind of G-protein coupled receptor (GPCR), which is encoded by a gene family composed of 30 genes. Bitterness can keep animals away from the toxic and harmful substances. When the animal tasted bitter substances, they will stimulate the tongue taste buds taste receptor cells to express TAS2Rs, then lead to a series of downstream signal transduction pathway, and the information is ultimately spread to the brain through drum rope nerve and glossopharyngeal nerve. It makes animals generate feelings of disgust, refuse to intake these bitter substances. In this paper, biological characteristics, signal transduction mechanism of bitter taste receptors, and the effects of bitters and bitter taste inhibitors on bitter taste receptors were briefly reviewed.

Cite this article

CAO Yingdong, LI Fangfang, ZHANG Yong, HUANG Tiejun . Bitter Taste Receptors: Biological Characteristics, Signal Transduction Mechanism, and Effects of Bitters and Bitter Taste Inhibitors[J]. Chinese Journal of Animal Nutrition, 2017 , 29(3) : 769 -775 . DOI: 10.3969/j.issn.1006-267x.2017.03.006

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