Molecular Mechanism for Milk Protein Content Decreasing of Dairy Cows Caused by Heat Stress during Summer

  • MIN Li ,
  • LI Dagang ,
  • TONG Xiong ,
  • WANG Gang
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  • Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China

Received date: 2019-08-23

  Online published: 2020-03-13

Abstract

Heat stress is one of the important factors restricting the development of dairy industry during summer. Heat stress causes the decreasing of milk protein content significantly, which seriously restricts the quality of milk. This review focused on the perspective of amino acid metabolism and transport in order to analyze the reasons for the decreasing of milk protein content, illuminated the effects of heat stress on the milk protein synthesis signaling pathways and apoptosis-related proteins in mammary gland, analyzed the physiological changes of cows after heat stress from gene and protein levels and revealed its molecular mechanism, in order to provide theoretical foundations and bases to alleviate the "milk protein decrease syndrome" of heat-stressed dairy cows during summer.

Cite this article

MIN Li , LI Dagang , TONG Xiong , WANG Gang . Molecular Mechanism for Milk Protein Content Decreasing of Dairy Cows Caused by Heat Stress during Summer[J]. Chinese Journal of Animal Nutrition, 2020 , 32(3) : 983 -988 . DOI: 10.3969/j.issn.1006-267x.2020.03.002

References

[1] IPCC.The physical science basis.Contribution of working group Ⅰ to the fourth assessment report of the intergovernmental panel on climate change[M].Cambridge,United Kingdom and New York,NY:Cambridge University Press,2007:433-497.
[2] BERNABUCCI U,BIFFANI S,BUGGIOTTI L,et al.The effects of heat stress in Italian Holstein dairy cattle[J].Journal of Dairy Science,2014,97(1):471-486.  
[3] 程建波,王伟宇,郑楠,等.自然生产条件下热应激周期变化揭示泌乳中期奶牛出现"热应激乳蛋白降低征"[J].中国畜牧兽医,2014,41(10):73-84.
[4] 闵力.基于生理代谢、蛋白组学和菌群多样性解析热应激对泌乳奶牛的影响[D].博士学位论文.北京:中国农业大学,2017:2-8.
[5] COWLEY F C,BARBER D G,HOULIHAN A V,et al.Immediate and residual effects of heat stress and restricted intake on milk protein and casein composition and energy metabolism[J].Journal of Dairy Science,2015,98(4):2356-2368.  
[6] HU H,ZHANG Y D,ZHENG N,et al.The effect of heat stress on gene expression and synthesis of heat-shock and milk proteins in bovine mammary epithelial cells[J].Animal Science Journal,2016,87(1):84-91.  
[7] BERNABUCCI U,BASIRICÒ L,MORERA P,et al.Effect of summer season on milk protein fractions in Holstein cows[J].Journal of Dairy Science,2015,98(3):1815-1827.  
[8] HAQUE M N,GUINARD-FLAMENT J,LAMBERTON P,et al.Changes in mammary metabolism in response to the provision of an ideal amino acid profile at 2 levels of metabolizable protein supply in dairy cows:consequences on efficiency[J].Journal of Dairy Science,2015,98(6):3951-3968.  
[9] 艾阳,曹洋,谢正露,等.热应激时奶牛血液中游离氨基酸流向与乳蛋白下降的关系研究[J].食品科学,2015,36(11):38-41.
[10] MIN L,ZHAO S G,TIAN H,et al.Metabolic responses and "omics" technologies for elucidating the effects of heat stress in dairy cows[J].International Journal of Biometeorology,2017,61(6):1149-1158.  
[11] 李庆章.奶牛乳腺发育与泌乳生物学[M].北京:科学出版社,2014:253-256.
[12] KAUFMAN J D,KASSUBE K R,ALMEIDA R A,et al.Short communication:high incubation temperature in bovine mammary epithelial cells reduced the activity of the mTOR signaling pathway[J].Journal of Dairy Science,2018,101(8):7480-7486.  
[13] RÍUS A G.Invited review:adaptations of protein and amino acid metabolism to heat stress in dairy cows and other livestock species[J].Applied Animal Science,2019,35(1):39-48.  
[14] POCHINI L,SCALISE M,GALLUCCIO M,et al.Membrane transporters for the special amino acid glutamine:structure/function relationships and relevance to human health[J].Frontiers in Chemistry,2014,2:61.
[15] PONCET N,TAYLOR P M.The role of amino acid transporters in nutrition[J].Current Opinion in Clinical Nutrition and Metabolic Care,2013,16(1):57-65.  
[16] 权素玉,南雪梅,蒋林树,等.动物氨基酸转运与感知系统研究进展[J].动物营养学报,2018,30(10):3810-3817.
[17] BURGOS S A,DAI M,CANT J P.Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signaling pathway[J].Journal of Dairy Science,2010,93(1):153-161.  
[18] BIONAZ M,LOOR J J.Gene networks driving bovine mammary protein synthesis during the lactation cycle[J].Bioinformatics and Biology Insights,2011,5:83-98.
[19] 代文婷.SARS介导蛋氨酸调节奶牛乳腺上皮细胞酪蛋白合成的机制研究[D].博士学位论文.杭州:浙江大学,2018:33-37.
[20] LI L,SUN Y,WU J,et al.The global effect of heat on gene expression in cultured bovine mammary epithelial cells[J].Cell Stress and Chaperones,2015,20(2):381-389.  
[21] BU D,MA L,GAO S T,et al.Heat stress decreases transcription of protein metabolism-related genes in mammary tissue of middle lactating cows[J].Journal of Dairy Science,2017,100(Suppl.2):223-224.
[22] 高胜涛,郭江,权素玉,等.热应激通过诱导奶牛乳腺细胞凋亡减少乳蛋白[J].动物营养学报,2016,28(5):1615-1625.
[23] COLLIER R J,STIENING C M,POLLARD B C,et al.Use of gene expression microarrays for evaluating environmental stress tolerance at the cellular level in cattle[J].Journal of Animal Science,2006,(Suppl.84):E1-E13.
[24] HU H,WANG J Q,GAO H N,et al.Heat-induced apoptosis and gene expression in bovine mammary epithelial cells[J].Animal Production Science,2015,56(5):918-926.
[25] DAI W T,ZOU Y X,WHITE R R,et al.Transcriptomic profiles of the bovine mammary gland during lactation and the dry period[J].Functional & Integrative Genomics,2018,18(2):125-140.  
[26] DADO-SENN B,SKIBIEL A L,FABRIS T F,et al.RNA-Seq reveals novel genes and pathways involved in bovine mammary involution during the dry period and under environmental heat stress[J].Scientific Reports,2018,8:11096.
[27] MIN L,ZHENG N,ZHAO S G,et al.Long-term heat stress induces the inflammatory response in dairy cows revealed by plasma proteome analysis[J].Biochemical and Biophysical Research Communications,2016,471(2):296-302.  
[28] SHAHZAD K,AKBAR H,VAILATI-RIBONI M,et al.The effect of calving in the summer on the hepatic transcriptome of Holstein cows during the peripartal period[J].Journal of Dairy Science,2015,98(8):5401-5413.  
[29] MIN L,CHENG J B,SHI B L,et al.Effects of heat stress on serum insulin,adipokines,AMP-activated protein kinase,and heat shock signal molecules in dairy cows[J].Journal of Zhejiang University-Science B,2015,16(6):541-548.  
[30] 马露,卜登攀,高胜涛,等.热应激影响奶牛乳腺酪蛋白合成的机制[J].动物营养学报,2015,27(11):3319-3325.
[31] LI Q L,YANG C H,DU J,et al.Characterization of miRNA profiles in the mammary tissue of dairy cattle in response to heat stress[J].BMC Genomics,2018,19(1):975.
[32] DO AMARAL B C,CONNOR E E,TAO S,et al.Heat stress abatement during the dry period influences metabolic gene expression and improves immune status in the transition period of dairy cows[J].Journal of Dairy Science,2011,94(1):86-96.  
[33] TAO S,MONTEIRO A P A,THOMPSON I M,et al.Effect of late-gestation maternal heat stress on growth and immune function of dairy calves[J].Journal of Dairy Science,2012,95(12):7128-7136.  
[34] ZHENG Y,CHEN K L,ZHENG X M,et al.Identification and bioinformatics analysis of microRNAs associated with stress and immune response in serum of heat-stressed and normal Holstein cows[J].Cell Stress and Chaperones,2014,19(6):973-981.  
[35] MIN L,CHENG J B,ZHAO S G,et al.Plasma-based proteomics reveals immune response,complement and coagulation cascades pathway shifts in heat-stressed lactating dairy cows[J].Journal of Proteomics,2016,146:99-108.
[36] 马露.基于组学技术分析日粮碳水化物平衡及热应激对奶牛机体代谢的影响机制[D].博士后研究工作报告.北京:中国农业科学院,2017:33-47.
[37] DEBERARDINIS R J,LUM J J,HATZIVASSILIOU G,et al.The biology of cancer:metabolic reprogramming fuels cell growth and proliferation[J].Cell Metabolism,2008,7(1):11-20.  
[38] MA L,YANG Y X,ZHAO X W,et al.Heat stress induces proteomic changes in the liver and mammary tissue of dairy cows independent of feed intake:an iTRAQ study[J].PLoS One,2019,14(1):e0209182.
[39] LI L,WANG Y R,LI C M,et al.Proteomic analysis to unravel the effect of heat stress on gene expression and milk synthesis in bovine mammary epithelial cells[J].Animal Science Journal,2017,88(12):2090-2099.  
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